Dennis E. Vance is Professor of Biochemistry at the University of Alberta. He did his Ph.D. at the
University of Pittsburgh supervised by Charles Sweeley. He did postdoctoral training at Harvard University with Konrad Bloch. He was
Professor and Chair of the Department of Biochemistry at the University of British Columbia (1982-86) and Associate Dean of Medicine
(1978 -81). He moved to the University of Alberta in 1986 to establish a Lipid Research Group. He is currently Director of the SCOLAR
(Stroke, Cardiovascular, Obesity, Lipid, Atherosclerosis Research) Training Program from CIHR and the Heart and Stroke Foundation of
Canada. He has served on CIHR committees including Chair of the Metabolism Committee. He is Principal Investigator on three grants from
CIHR. His research on mammalian phosphatidylcholine metabolism has been recognized by the Boehringer Mannheim Canada Prize of the Canadian
Biochemical Society in 1989, the Heinrich Wieland Prize awarded in 1995 in Munich, Germany, election as Fellow of the Royal Society of
Canada (1996), a Canada Research Chair (2002) and the Avanti Award from the American Society of Biochemistry and Molecular Biology (2006).
He presented the Laurens van Deenen lecture at the 2008 meeting of the International Conference on the Bioscience of Lipids. He co-authored
with Geoff Zubay Principles of Biochemistry, an introductory biochemistry textbook and co-edited with Jean Vance five editions of an
advanced textbook, Biochemistry of Lipids, Lipoproteins and Membranes. The fifth edition was published in March, 2008. He was an Executive
Editor of the international journal BBA for 9 years. Prof. Vance became Editor in Chief of BBA in January, 2007. Dr. Vance became a University
Professor at the University of Alberta in 2008. He received the Kaplan Award from the University of Alberta in 2009.
E. Arnér, (Stockholm, Sweden)
Arnér is an MD PhD and received his degrees from Karolinska Institutet in Stockholm, Sweden.
In his early work he studied nucleotide metabolism and the biochemistry of nucloside analogs used as anticancer or antiviral drugs. Later
he moved to studies of redox biochemistry, with a focus on the mammalian thioredoxin system and selenoprotein synthesis and function.
With that field of interest, he first worked with Arne Holmgren, Stockholm, and then August Böck, Munich, before establishing his
own line of research back at Karolinska Institutet, where he is now head of the biochemistry division, in the department of medical biochemistry
and biophysics. He has served as dean of postgraduate education at Karolinska Institutet and he was Editor of BBA General Subjects for
some years before becoming Executive Editor in 2008.
U. Brandt, (Frankfurt am Main, Germany)
Ulrich Brandt is Professor of Biochemistry and Molecular Bioenergetics at the Centre for Biological
Chemistry in Frankfurt am Main. He graduated in Biochemistry from the Eberhard-Karls University in Tubingen and obtained his PhD from
the Ludwig-Maximilians University in Munich for his research on specific inhibitors of the mitochondrial cytochrome bc1 complex and functional
aspects of cytochrome c oxidase.
Between 1991 and 1993, Dr. Brandt was a Feodor-Lynen fellow of the Humboldt Foundation in the laboratory
of Bernard L. Trumpower at the Dartmouth Medical School, New Hampshire, where he started working in the field of yeast genetics. Late
in 1993 He returned to Germany to the Johann-Wolfgang-Goethe University in Frankfurt am Main, where he became a Docent in 1994 and a
Professor of Biochemistry in 1996. Since 1997 Dr. Brandt is Vice-Director of the Centre of Biological Chemistry at the Medical Faculty,
Goethe-University. In the same year he was elected Secretary General of the German Society for Biochemistry and Molecular Biology. He
is also founding member of the Cluster of Excellence "Macromolecular Complexes" of the Goethe-University.
His research interest focuses
on the structure and function of respiratory chain complexes. Dr. Brandt's group has established the strictly aerobic yeast Yarrowia
lipolytica as a powerful model to study mitochondrial complex I. Taking advantage of versatile yeast genetics, a broad range of biochemical
and biophysical approaches is applied. Current projects are
Crystallization of affinity purifed complex I to solve its 3D
structure
Site directed mutagenesis of complex I for structure/function analysis
Functional analysis of wild-type
and mutant analysis, including the measurement of proton translocation and ROS formation.
More recently, Dr. Brandt has expanded
his studies to mitochondria as a whole and redox-signaling in order to bridge classical bioenergetics and the exciting developments in
cell biology and the central role of mitochondria in apoptosis, degenerative disorders and ageing that has been emerging in recent years.
P. Brzezinski, (Stockholm, Sweden)
Peter Brzezinski obtained his Ph.D. at Göteborg University in Sweden in 1989. He then moved to UCSD
in La Jolla to work as a postdoctoral fellow with George Feher at the Physics Department. In 1991, he became an assistant professor at
Goteborg University and in 1999 he assumed a professorship at Stockholm University. Peter has worked as the Executive Editor of Biochim.
Biophys. Acta - Bioenergetics and as a Handling Editor of FEBS Lett since 2003. In 2007, he was elected member of the Royal Swedish Academy
of Sciences.
Broadly speaking, Peter's research interests are focused on the understanding mechanisms of transport processes across
and along biological membranes. One line of studies is focused on understanding redox-coupled proton pumping by respiratory oxidases.
P. Cook, (Norman, OK, USA)
Paul F. Cook received a B. A. in Biology and Chemistry in 1972 from Our Lady of the Lake College in
San Antonio, Texas, and the Ph.D. in Biochemistry in 1976 from the University of California at Riverside, where he worked with Randolph
T. Wedding on the mechanisms of the cysteine biosynthetic enzymes in Salmonella. He carried out postdoctoral research on isotope effects
in enzyme-catalyzed reactions with W. W. Cleland at the University of Wisconsin, and in 1980 took a position as Assistant Professor in
the Department of Biochemistry, and moved to the Department of Biochemistry at the Texas College of Osteopathic Medicine in 1982. He
was promoted to Associate Professor in 1984, and to Professor in 1986. He served as Chairman of the Department of Microbiology and Immunology
from 1988-93. Dr. Cook was Visiting Professor at the Institut für Physiologische Chemie of Universität Würzburg in 1987
and 1995. In 1996, Dr. Cook moved to the Department of Chemistry and Biochemistry at the University of Oklahoma, where he is the Grayce
B. Kerr Centennial Professor of Biochemistry. Dr. Cook has graduated 28 Ph.D. students. He has received a number of awards, including
a Research Career Development Award from the National Institutes of Health, and an Alexander von Humboldt Fellowship. He has served
on a number of editorial boards, including the Journal of Biological Chemistry, and grant review panels, including the Biochemistry Study
Section of the National Institutes of Health. His research interests are in the area of enzyme kinetics and mechanism. He has edited
a book entitled "Enzyme Mechanism from Isotope Effects" and co-authored a book with W. W. Cleland entitled "Enzyme Kinetics and Mechanism".
He has authored more than 200 peer-reviewed research articles.
A. Corbett, (Atlanta, GA, USA)
Anita H. Corbett received her undergraduate degree in Chemistry/Biochemistry from Colgate University and
her PhD in Biochemistry from Vanderbilt University. She was a post-doctoral fellow at Dana Farber Cancer Institute/Harvard Medical School
where she first developed an interest in macromolecular transport between the nucleus and the cytoplasm. She joined the faculty in the
Biochemistry Department at Emory University School of Medicine in Atlanta, GA USA in 1997. She is currently a Professor of Biochemistry
at Emory. Her laboratory studies macromolecular transport into and out of the nucleus including protein import and mRNA processing/export.
The laboratory uses budding yeast to study these evolutionarily conserved processes but also employs both Drosophila and cultured cells.
W. Dowhan, (Houston, TX, USA)
Professor, Department of Biochemistry &Molecular Biology University of Texas-Houston Medical School
Education: Ph.D., University of California, Berkeley Postdoctoral Fellow, Harvard Medical School Research Interests: Structure,
function and assembly of cell membranes. A combined molecular genetic and biochemical approach is being used to study the structure,
function, and biogenesis of biological membranes in prokaryotic (E. coli) and eukaryotic (yeast) microorganisms. Studies utilizing E.
coli focus on understanding biological processes that are similar in both simple and complex organisms. A major goal is to understand
the role individual phospholipid species and general membrane phospholipid composition play in cell function. Specific roles for phospholipids
at the molecular level have been defined for translocation of proteins across membranes, energy transduction processes, signal transduction,
cell division, and the assembly and function of integral membrane proteins. A major emphasis is to understand how membrane proteins interact
with their lipid environment to attain final topological organization. Studies using yeast focus on problems that are unique to
eukaryotic systems. Mutants in phospholipid metabolism are being used to study the roles of mitochondrial-specific anionic phospholipids
cardiolipin and phosphatidylglycerol in the synthesis, assembly, and function of mitochondrial membrane proteins. A primary role of cardiolipin
is to organize components of the electron transport system into supermolecular complexes while both anionic phospholipids are required
for the translation of nuclear- and mitochondrial-encoded components of the electron transport chain. e-mail: William.Dowhan@uth.tmc.edu
R. Epand, (Hamilton, ON, Canada)
Richard M. Epand is currently a Professor in the Department of Biochemistry and Biomedical Sciences
at McMaster University in Hamilton, Ontario, Canada. Dr. Epand received his A.B. from the Johns Hopkins University and his Ph.D. in the
Department of Biochemistry of Columbia University under the direction of Professor I.B. Wilson. Richard Epand then did postdoctoral studies
with Professor Harold Scheraga at Cornell University and with Professor Leloir at the Instituto de Investigaciones Bioquimicas in Buenos
Aires. Dr. Epand has held academic positions at the University of Guelph before joining McMaster.
Dr. Epand is currently co-Executive
editor of Biochim. Biophys. Acta - Biomembranes. He is an Elected Fellow of the Biophysical Society and was given a Senior Scientist
Award from the Canadian Institutes of Health Research. Professor Epand is the recipient of 1999 Avanti Award for Research in Lipids from
the Biophysical Society.
Richard Epand current research interests in the general area of the functions of biological membranes. Studies
range from the properties of proteins in membranes to the study of membrane components in living cells.
Y. Goto, (Osaka, Japan)
Dr. Goto graduated from the Department of Biology, Osaka University (1977), and obtained a Doctoral Degree
(1982) from the Graduate School of Science, Osaka University. He stayed at the Medical School of Tokushima University (1982-1984), Graduate
School of Science, Osaka University (1984-1998) before joining the Institute for Protein Research as a professor in 1998. He experienced
postdoctoral period in 1986-1988 with Prof. Anthony Fink, UC Santa Cruz. During his postdoctoral period, he performed pioneering work
on understanding the salt-dependent conformational change of denatured proteins and molten globule states. After returning back to Osaka,
he made significant contributions in clarifying the mechanism of protein folding focusing on the conformational stability of the molten
globule states and the α→ transition during folding of -lactoglobulin. At the Institute for Protein Research, his
group developed several key techniques for studying amyloid fibrils. His current research interests include (1) mechanism of protein
folding, (2) amyloid fibril formation, and (3) conformational stability of proteins. He is the Executive Council Member of Protein Society
(2007-present) and Executive Editor of BBA-Proteins and Proteomics (2008-present).
W. Hahn, (Boston, MA, USA)
William C. Hahn, M.D., Ph.D.,Associate Professor of Medicine Harvard Medical School, Department of Medical
Oncology, Dana-Farber Cancer Institute, Senior Associate Member, Broad Institute of MIT and Harvard.
Dr. William C. Hahn is a medical
oncologist and Associate Professor in the Department of Medical Oncology at the Dana-Farber Cancer Institute and a Senior Associate Member
of the Broad Institute of MIT and Harvard. He directs the Center for Cancer Genome Discovery at the Dana-Farber Cancer Institute.
Dr. Hahn and his colleagues helped demonstrate that activation of the reverse transcriptase telomerase plays an essential role in malignant
transformation. His current work focuses on the understanding the cooperative genetic interactions that lead to malignant transformation
and the creation of novel experimental model systems for the study of normal and malignant epithelial biology. In addition, he is a founding
member of The RNAi Consortium, Broad Institute-based effort to develop genome scale RNA interference reagents and the technologies for
their use. His laboratory has pioneered the use of integrated functional genomic approaches to identify and validate cancer targets.
Clinically, he is a member of the Lank Center for Genitourinary Oncology and is devoted to the development of new therapeutic strategies
for the treatment of prostate and other cancers.
Dr. Hahn has been the recipient of many honors and awards including a Harvard National
Scholarship, a Damon Runyon-Walter Winchell Cancer Research Fund Fellowship, Howard Hughes Medical Institute Pre- and Postdoctoral Fellowships,
a Doris Duke Charitable Foundation Clinical Scientist Development Award, the 2000 Wilson S. Stone Award from M.D. Anderson Cancer Center
for outstanding research in cancer, a Kimmel Scholar Award, and the Howard Temin Award from the National Cancer Institute. In 2005, Dr.
Hahn was elected to the American Society of Clinical Investigation.
Dr. Hahn received his A.B. from Harvard University in Biochemical
Sciences summa cum laude in 1987 and his M.D and Ph.D. from Harvard Medical School in 1994. He then completed clinical training in Internal
Medicine at the Massachusetts General Hospital and Medical Oncology at the Dana-Farber Cancer Institute. He conducted his postdoctoral
studies with Dr. Robert Weinberg at the Whitehead Institute for Biomedical Research and joined the faculty of DFCI and Harvard Medical
School in 2001.
J. Keller, (Baton Rouge, LA, USA)
Professor, Associate Executive Director of Basic Research, Hibernia National Bank/Edward G. Schlieder Chair,
and Director of the newly established Institute for Dementia Research &Prevention at the Pennington Biomedical Research Center, LSU
System, Baton Rouge Louisiana.
Dr. Keller received his Ph.D. in molecular and cellular biology at the University of Kentucky in 1999.
Since that time, Dr. Keller's efforts have been focused on studying aging, oxidative stress, proteasome biology, and Alzheimer's disease
research. The work of Dr. Keller in the last 2 years has been focused on understanding the ability of a high fat diet to modulate brain
function and brain pathology during aging. In particular, we are interested on the ability of these high fat diets to accelerate brain
aging and promote the development of age-related neurodegenerative diseases. These efforts are a part of a multi-group effort at the
Center headed by Dr Keller. In addition to these research efforts, Dr Keller serves on the editorial board of nine journals, is a reviewer
for multiple NIH grant review study sections, and is a member of multiple government task forces focused on health and dementia.
S. Krag, (Baltimore, MD, USA)
Professor, Biochemistry and Molecular Biology, 615 North Wolfe Street, W8513, Bloomberg School of Public Health,
Baltimore, Maryland 21205. 410.955.3869 office
Dr. Krag received a B.S. in chemistry and biology from Texas Lutheran College, received
her Ph.D. in biochemistry from Johns Hopkins University, and completed postdoctoral work at the Center for Cancer Research at Massachusetts
Institute of Technology. She joined the faculty of the Department of Biochemistry at the Johns Hopkins Bloomberg School of Public Health
in 1976. She was the Associate Dean for Graduate Education and Research at the Johns Hopkins Bloomberg School of Public Health from 1992
through 2007. She is currently a professor in the Bloomberg's School Department of Biochemistry and Molecular Biology. Her research focuses
on glycobiology; in particular, her lab studied lipid intermediates (dolichol) in N-linked glycosylation, an important process in cell-surface
interactions. Her current work involves strategies to increase glycan occupancy in glycoprotein therapeutics. She taught courses in molecular
biology of disease, biochemistry, and public health biology at the Bloomberg School of Public Health. She now teaches a course in responsible
conduct of research/research ethics. She is an Executive Editor of BBA-General Subjects.
F. Lottspeich, (Martinsried bei Munchen, Germany)
Education: University of Vienna, PhD (Dr. phil.), 1978 Max Planck Institute of Biochemistry,
Scientist, 1977-1984 Max-Planck-Institute of Biochemistry, Head of Microsequencing facility, 1984-1989 University of Innsbruck,
Habilitation (Dr. rer. nat. habil.) in Biochemistry, 1990 University Munich, Habilitation (Dr. med. habil.) in Experimental Medicine,
1990 Max Planck Institute of Biochemistry , Head of Protein Analytics, since 1990 Research focus: The primary focus of the
Lottspeich group is in method development in protein analytics and proteomics. Mass spectrometry, amino acid sequencing, protocols for
sample preparation and improved and more sensitive protein identification methods by mass spectrometry are established. Recently, ICPL
(Isotope coded protein label) has been developed as a powerful tool to identify and relatively quantify thousands of proteins within
complex protein mixtures. All these techniques are directly used in many collaborative projects within the institute, with universities
and Max-Planck-Institutes throughout Germany. One biological research project is the Hypusin containing protein, its structure-function
relationship and the elucidation of the function of this higly conserved protein. The goal of the MONACO project focuses on the mode
of action of new lead compounds for drug discovery from natural sources related to tradititional chinese medicine. A HepG2 cellline is
treated with isolated natural compounds under standarized conditions, to elucidate the proteome profile. Within the Kidney Cancer project
tumour markers are identified, using microdissected tissue as source for proteome analysis. Another tumour project deals with identification
of marker proteins out of plasma from patients with Colon Carcinoma. Friedrich has authored over 650 original publications, edited
several books and is Past-president of the European Proteomics Association (EuPA) and Vice President of the German Proteomics Society
(DGPF). Homepage: http://www.biochem.mpg.de/lottspeich/
B. Oostra, (Rotterdam, The Netherlands)
Dr. Ben A. Oostra is professor of Molecular and Clinical Genetics at the Erasmus MC of the Erasmus University.
He received his MSc in 1977 and his PhD in 1981 in Biochemistry from Groningen University, The Netherlands. He completed post-doctoral
fellowships at National Institute of Medical Research, Mill Hill, London UK and at Laboratory for Medical Biochemistry, Leiden University
prior to accepting the position at the Erasmus University in 1985. His research focuses first on genetic molecular and biochemical studies
in neurogenetic disorders and second on genetics of complex disorders with a specific interest in isolated populations.
C. Peterson, (Worcester, MA, USA)
Craig L. Peterson is a tenured Professor and Vice-Chair in the Program in Molecular Medicine at the
University of Massachusetts Medical School. He received his B.S. in Molecular Biology from the University of Washington in 1983 and
his Ph.D. in Molecular Biology from the University of California, Los Angeles in 1988. As a Helen Hay Whitney Foundation postdoctoral
fellow with the late Ira Herskowitz at the University of California, San Francisco, Dr. Peterson initiated genetic studies that ultimately
led to the discovery of the first chromatin remodeling enzyme, yeast SWI/SNF. He joined the faculty of the Program in Molecular Medicine
in 1992 where he has pioneered genetic and biochemical analyses of chromatin remodeling enzymes, chromatin higher order folding, and
the role of chromatin dynamics in transcription, DNA repair, and DNA replication. In addition to serving as an Executive Editor of BBA
Gene Regulatory Mechanisms, he is also on the editorial boards of Molecular Cell, Current Biology, PLoS Biology, and Molecular and Cellular
Biology.
Nikolaus Pfanner studied medicine in Munich and was trained in biochemistry and molecular cell biology in
the laboratories of Walter Neupert (Munich, Germany) and James Rothman (Princeton, New Jersey). Since 1992 he has been a professor and
Chairman of Biochemistry at the Institute of Biochemistry and Molecular Biology, University of Freiburg, Germany. His research interests
include the mechanisms of intracellular protein sorting and assembly, and the function and biogenesis of mitochondria. He is a member
of the European Molecular Biology Organization (EMBO), the Academia Europaea, the German Academy of Sciences Leopoldina and, the Academy
of Sciences Heidelberg. Nikolaus Pfanner has received the Max Planck Research Award, the Gottfried Wilhelm Leibniz Award, and the Leopoldina
Research Award. He has served as the Chairman of the Study Section of Biological Chemistry and Biophysics of the German Science Foundation
and is currently the President of the German Society for Biochemistry and Molecular Biology.
Y. Shai, (Rehovot, Israel)
Yechiel Shai is a Professor of Biochemistry and Biophysics at the Department of Biological Chemistry at the
Weizmann Institute of Science. He received a BSc. in Chemistry in 1977 from Bar-Ilan University, MSc in Organic Chemistry in 1979 and
Ph.D. in Peptide Chemistry in 1985 both from the Weizmann Institute of Science. He then carried out postdoctoral research on molecular
recognition at the National Institute of Science, Bethesda until 1988, when he took a position as an investigator at the Department of
Membrane Research at the Weizmann Institute of Science. He was promoted to Associate Professor on 1995 and to full Professor on 2002.
Yechiel Shai is studying peptide/protein-membrane interactions and protein-protein recognition within the membrane milieu. More specifically,
he is studying membrane active innate immunity host defense antimicrobial and antifungal peptides and lipopeptides. Since 1991 he has
established the "carpet" mechanism as an efficient membrane destruction process used by many AMPs and lipopeptides, and studies parameter
controlling the cell specificity of AMPs. In the field of virus-host interaction he is investigating how gp41, the envelop protein of
HIV1 catalyzes virus-cell fusion. He also studies new mechanisms by which HIV can evade the immune response. In addition, as part of
studying general aspects of protein-protein recognition within the membrane milieu, he discovered that peptides with opposite chiralities
can specifically assemble in the membrane, in contrast to the well accepted dogma on recognition outside the membrane milieu. These findings
allow to develop new D,L-amino acid containing peptides that serve as novel inhibitors of membrane proteins.
F. Spener, (Graz, Austria)
Friedrich Spener received a Ph.D. in chemistry from the University of Graz in Austria in 1968, where he carried
out a thesis on the intestinal absorption of long-chain triethers of glycerol. After two and a half years of postdoctoral work at the
Hormel Institute of the University of Minnesota in the United States he joined first the Federal Institute for Lipid Research in Münster,
Germany. Then, he made his career in lipid biochemistry and biotechnology at the University of Münster, where he was Professor of
Biochemistry until his retirement there in 2004. He was asked subsequently to join the University of Graz and the Medical University
of Graz to develop the Lipidomics Research Center as a joint platform for the strong lipid community in Graz. The scientific work of
Professor Spener is published in over 280 original contributions, reviews and book chapters as well as in several patents. He is particularly
engaged in cellular transport of fatty acids, signaling and gene regulation by fatty acids, affected through cooperation of lipid binding
proteins with nuclear receptors. Other lines of interests were medium-chain fatty acid synthesis in oil seeds, enzyme technology, and
biosensorics. He was first Editor and in the last nine years Executive Editor for the BBA Molecular and Cell Biology of Lipids section.
S. Triezenberg, (East Lansing, MI, USA)
Steven J. Triezenberg is the Director of the Van Andel Education Institute, Dean of the Van Andel Institute
Graduate School, and a scientific investigator in the Van Andel Research Institute, in Grand Rapids, Michigan. Dr. Triezenberg received
his bachelor's degree in biology and education at Calvin College. His Ph.D. training in cell and molecular biology at the University
of Michigan was followed by postdoctoral research at the Carnegie Institution of Washington. Before joining the Van Andel Institute in
2006, Dr. Triezenberg was a faculty member of the Department of Biochemistry and Molecular Biology at Michigan State University for more
than 18 years. His research explores the regulation of gene expression, with current projects studying events during herpes simplex virus
infections and in the response of plants to low temperature.
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