The International Journal for the Rapid Publication of Full Original Research Papers and Critical Reviews in Organic Chemistry
Guide for Authors
Please follow these instructions carefully to ensure that the review and publication of your paper are as swift and efficient as possible.
These notes may be copied freely.
Tetrahedron seeks to publish experimental or theoretical research results of outstanding significance
and timeliness in the field of Organic Chemistry, Bioorganic Chemistry and related disciplines. Publications may be in the form of Articles,
Reports, or Symposia-in-Print.
The contents of papers are the sole responsibility of the authors, and publication shall not imply
the concurrence of the Editors or Publisher.
ARTICLES should describe original research in organic chemistry of high quality
and timeliness. Because of restrictions on the size of the journal, priority will be given to those contributions describing scientific
work having as broad appeal as possible to the diverse readership. We ask referees to help in the selection of articles which have this
breadth and suggest that papers covering narrower aspects of the field be sent to journals specializing in those areas. It is strongly
recommended that articles be written in English.
REPORTS are specially commissioned reviews of research results of topical importance.
Such articles, published only in English, are commissioned in appropriate fields by the Editors of Tetrahedron Reports.
SYMPOSIA-IN-PRINT
comprise collections of original research papers (including experimental sections) covering timely areas of organic chemistry. Topics
for forthcoming Symposia are announced in the journal from time to time. A Guest Editor will invite authors active in the field to submit
papers which are then reviewed and processed for publication by the Guest Editor under the usual refereeing system. Opportunity is also
provided for other active investigators to submit contributions. These Symposia are published in English.
Manuscript submission
Articles: Authors should submit their manuscripts to the appropriate regional editor (see below) via the online submission
page of this journal at http://ees.elsevier.com/tet. Authors will be guided stepwise through the creation and uploading
of the various files. The system automatically converts source files to a single Adobe Acrobat PDF version of the article, which is used
in the peer review process. Please note that even though manuscript source files are converted to PDF at submission for the review process,
these source files are needed for further processing after acceptance. All correspondence, including notification of the editor's decision
and requests for revision, takes place by e-mail and via the author's home page. A printed copy of the manuscript is not required at
any stage of the process.
The following items should be submitted to the appropriate regional editor via the online submission page:
Manuscript. It is not necessary to embed graphics in the text, but if you do so please note that separate
graphic files will always be required for proof production when a manuscript is accepted for publication. Graphics should be submitted
as separate, highresolution artwork files. These will be automatically incorporated into the single PDF that the system creates for review.
Graphical abstract for the contents list (submitted as a separate document).
Cover letter: highlighting
the novelty, significance, and urgency of the submitted work, which merits rapid publication and providing details of other relevant
information, e.g., submitted or in press manuscripts.
List of potential referees (Separate document).
Manuscripts should be addressed to the appropriate regional editor:
Articles from Austria, Belgium, France, Germany, Portugal,
Spain and Switzerland:
Professor L. Ghosez, Institut Européen de Chimie et de Biologie
(IECB), 2, rue Robert Escarpit,
33607 Pessac Cedex, France.
China:
Professor Lin Guo-Qiang, Shanghai Institute of Organic Chemistry,
Chinese Academy
of Sciences, China.
Japan and South Korea:
Professor K. Tomioka, Kyoto University, Department of Synthetic Medicinal
Chemistry, Graduate School of Pharmaceutical Sciences, Yoshida Sakyo-ku, Kyoto 606-8501, Japan.
The Americas:
Professor
S. F. Martin, Chemistry and Biochemistry Department,
The University of Texas, USA.
All regions other than those specified above:
Professor R. J. K. Taylor, Department of Chemistry, University of
York, UK. NOTE: Papers from India must be addressed to the Associate
Editor for India, Dr. G. Pandey.
Tetrahedron Symposia-in-Print: To the Guest Editor as
announced for the particular symposium.
Tetrahedron Reports: Reports should not be submitted to the
online submission page of this journal, instead manuscripts should
be e-mailed to the appropriate regional editor:
The Americas:
Professor T. Lectka, New Chemistry Building 315, John
Hopkins
University, USA. E-mail: lectka@jhu.edu
Other locations:
Professor W. B. Motherwell, Department
of Chemistry, University College London, UK. E-mail: w.b.motherwell@ucl.ac.uk
Templates are provided in order
to allow authors to view their paper in a style close to the final printed form. Their use is optional. The templates can be found
at http://www.elsevier.com/wps/find/P04_116.cws_home/authors_guide. All manuscripts will be fully typeset from the author's
electronic files. It should be noted that due to defined typesetting standards and the complex requirements of electronic publishing,
the Publisher will not always be able to exactly match the layout the author has submitted. In particular, in the finished journal article,
figures and tables are usually placed at the top or bottom of pages. The template is only intended to be used in assisting with the preparation
and submission of manuscripts.
It should be noted that the use of the journal template is not a requirement and its adoption will
neither speed nor delay publication. Elsevier can handle most major word processing packages and in general most formatting applied by
authors for style and layout is replaced when the article is being typeset.
These templates contain a large number of macros. To
ensure successful PDF conversion by the online submission system, it is important that the author saves a new document based on the template,
rather than saving the template itself. To use the template, the author should save the final document as a Word file with a ".doc" extension
(rather than the ".dot" extension).
Please ensure that the graphical abstract is included as page 1 of your manuscript when submitting
online. For further instructions on the preparation of electronic artwork please see http://www.elsevier.com/wps/find/authors.authors/authorartworkinstructions.
Language: Articles must be written in clear, concise, grammatical English. Any author who is not fluent in idiomatic English
is urged to gain assistance with manuscript preparation. Reviewers are not expected to correct grammatical errors and any deficiency
in this area may detract from the scientific content of the paper.
Language editing: International Science Editing and Asia
Science Editing can provide English language and copyediting services to authors who want to publish in scientific, technical, and medical
journals and need assistance before they submit their article or before it is accepted for publication. Authors can contact these services
directly: International Science Editing (http://www.internationalscienceediting.com) and Asia Science Editing (http://www.asiascienceediting.com)
or, for more information about language editing services, authors may contact authorsupport@elsevier.com who will be happy
to deal with any questions. Please note Elsevier neither endorses nor takes responsibility for any products, goods, or services offered
by outside vendors through our services or in any advertising. For more information please refer to our terms and conditions (http://www.elsevier.com/wps/find/termsconditions.cws_home/termsconditions).
Journal policy: Submission of an article implies that the work described has not been published previously
(except in the form of an abstract or as part of a published lecture or academic thesis), that it is not under consideration for publication
elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was
carried out, and that, if accepted, it will not be published elsewhere in the same form, in English or in any other language, without
the written consent of the publisher. Authors accept full responsibility for the factual accuracy of the data presented and should obtain
any authorization necessary for publication. As such the contents of the papers are the sole responsibility of the authors and publication
shall not imply the concurrence of the editors or publisher.
All papers are submitted to referees who advise the editor on the matter
of acceptance in accordance with the high standards required, on the understanding that the subject matter has not been previously published
and is not under consideration elsewhere. Referees will be asked to distinguish contributions meeting the above requirements and having
an element of novelty, timeliness, and urgency that merits publication in the journal. We ask referees to help in the selection of articles
that have this breadth and suggest that papers covering narrower aspects of the field be sent to journals specializing in those areas.
Referee names are not disclosed, but their views are forwarded by the editor to the authors for consideration. Authors are encouraged
to suggest names of several experts in the field when papers are first submitted or at any time in the evaluation process.
Copyright
guidelines: Upon acceptance of an article, authors will be asked to sign a "Journal Publishing Agreement" (for more information on
this and copyright see http://authors.elsevier.com). Acceptance of the agreement will ensure the widest possible dissemination
of information. An e-mail (or letter) will be sent to the corresponding author confirming receipt of the manuscript together with a "Journal
Publishing Agreement" form. If excerpts from other copyrighted works are included, the author(s) must obtain written permission from
the copyright owners and credit the source(s) in the article. Elsevier has preprinted forms for use by authors in these cases: contact
Elsevier's Rights Department, Oxford, UK: phone (+44) 1865 843830, fax (+44) 1865 853333, e-mail permissions@elsevier.com.
Requests may also be completed online via the Elsevier homepage (http://www.elsevier.com/locate/permissions).
General requirements: The corresponding author's full mailing address, including mail codes,
phone number, fax number, and e-mail address should be included. Authors are asked to provide four keywords, which will be used for indexing
purposes. The manuscript should be compiled in the following order: Graphical Abstract, Title, Authors, Affiliations, Abstract, Keywords,
Introduction, Results, Discussion, Conclusion, Experimental, Acknowledgments, References and Notes, Tables, Legends, Figures, and Schemes.
Graphical abstracts: Authors must supply a graphical abstract at the time the paper is first submitted. The abstract should
summarise the contents of the paper in a concise, pictorial form designed to capture the attention of a wide readership and for compilation
of databases. Carefully drawn chemical structures that serve to illustrate the theme of the paper are desired. Authors may also provide
appropriate text, not exceeding 30 words. The content of the graphical abstract will be typeset and should be kept within an area of
5 cm by 17 cm. Authors must supply the graphic separately as an electronic file. For examples of graphical abstracts, please consult
a recent issue of the journal or visit the journal home page on ScienceDirect at http://www.sciencedirect.com/science/journal/00404020
and click "Sample Issue Online".
Title: The title should be brief, specific, and rich in informative words; it should not
contain any literature references or compound numbers.
Authors and affiliations: Where possible, supply given names, middle
initials, and family names for complete identification. Use superscript lowercase letters to indicate different addresses, which should
be as detailed as possible and must include the country name. The corresponding author should be indicated with an asterisk, and contact
details (fax, e-mail) should be placed in a footnote. Information relating to other authors (e.g., present addresses) should be placed
in footnotes indicated by the appropriate symbols (see below).
Abstracts: Authors must include a short abstract of approximately
four to six lines that states briefly the purpose of the research, the principal results, and major conclusion(s). References and compound
numbers should not be mentioned in the abstract unless full details are given.
Text should be subdivided in the simplest possible
way consistent with clarity. Headings and subheadings should reflect the relative importance of the sections, and all headings should
be numbered.
In the introductory section of the manuscript, the author should strive to define the significance of the work and the justification
for its publication. Any background discussion should be brief and restricted to pertinent material. Ensure that all tables, figures,
and schemes are cited in the text in numerical order. The preferred position for chemical structures should be indicated. Trade names
should have an initial capital letter. All measurements and data should be given in SI units where possible, or in other internationally
accepted units. Abbreviations should be used consistently throughout the text, and all non-standard abbreviations should be defined on
first usage. Authors are requested to draw attention to hazardous materials or procedures by adding the word CAUTION followed
by a brief descriptive phrase and literature references if appropriate.
Reports: When submitting a Tetrahedron report, authors
should include biographical information for each author as well as a black-and-white photograph. Each biography should be one paragraph
(approximately 150-200 words) and should include date and place of birth, universities attended, degrees obtained, principal professional
posts held, present title, a line or two about the major research interests, and anything else professionally relevant that is of special
interest. Authors must supply a graphical abstract when the report is first submitted, which will summarise the contents of the report
in a concise pictorial form (see provisos section: Manuscript preparation: Graphical Abstracts for more detailed information).
Experimental
section: Authors should be as concise as possible in experimental descriptions. The Experimental section must contain all the information
necessary to guarantee reproducibility. An introductory paragraph containing information concerning solvents, sources of less common
starting materials, special equipment, etc., should be provided. The procedures should be written in the past tense and include the weight,
mmol, volume, etc., in parentheses after the names of the substances or solvents. General reaction conditions should be given only once.
The title of an experiment should include the chemical name and compound number of the product prepared; subsequently, this compound
should be identified by its number. Details of the workup procedure must be included. Physical and spectroscopic data, including NMR,
high-resolution mass analysis, and elemental analysis, can be included in the experimental section or presented in tables.
Acknowledgements:
An acknowledgement section may be included. It should be placed after the manuscript text and before the references.
Abbreviations:
Standard ACS abbreviations should be used throughout the manuscript and are employed without periods. The preferred forms for some of
the more commonly used abbreviations are mp, bp, °C, K, min, h, mL, μL, g, mg, μg, cm, mm, nm, mol, mmol, μmol, M, mM, μM, ppm, HPLC, TLC, GC, 1H NMR, GC-MS, HRMS, FABHRMS, UV, IR, EPR, ESR, DNase, ED50, ID50, IC50, LD50, im, ip, iv, mRNA, RNase, rRNA,
tRNA, cpm, Ci, dpm, Vmax, Km, k, t1/2. All non-standard abbreviations should be defined following
the first use of the abbreviation. For a detailed listing of standard abbreviations, see The ACS Style Guide; American Chemical Society:
Washington, DC, 1997.
References and notes: In the text, references should be indicated by superscript Arabic numerals which
run consecutively through the paper and appear after any punctuation. Please ensure that all references are cited in the text and vice
versa. The reference list should preferably contain only literature references, although other information (e.g., experimental details)
can be placed in this section. Preferably, each reference should contain only one literature citation. Authors are expected to check
the original source reference for accuracy. Journal titles should be abbreviated according to American Chemical Society guidelines (The
ACS Style Guide; Dodd, J. S., Ed.; American Chemical Society:
Washington DC, 1997). A list of currently accepted journal abbreviations
may be found the journal home page at www.elsevier.com/locate/tet. Formatting for common references are shown below.
Scientific articles:
1. Barton, D. H. R.; Yadav-Bhatnagar, N.; Finet, J.-P.; Khamsi, J.Tetrahedron Lett.1987, 28,
3111.
Books:
2. Doe, J. S.; Smith, J. In Medicinal Chemistry; Roe, P., Ed.;
Pergamon: Oxford, 1990; Vol. 1, pp 301-383.
Patent/Chem. abstract:
3. Lyle, F. R. U.S. Patent 6,973,257, 1995; Chem. Abstr.1995, 123, 2870.
Meeting abstract:
4. Prasad, A.; Jackson, P. Abstracts of Papers, Part 2, 212th
National Meeting of the American Chemical
Society, Orlando,
FL, Aug 25-29, 1996; American Chemical Society: Washington, DC, 1996; PMSE 189.
Citing and listing of Web references:
As a minimum, the full URL should be given. Any further information, if known (author names, dates, reference to a source publication,
etc.), should also be given. Web references can be listed separately (e.g., after the reference list) under a different heading if desired,
or can be included in the reference list.
The digital object identifier (DOI) may be used to cite and link to electronic documents.
The DOI consists of a unique alphanumeric character string which is assigned to a document by the publisher upon the initial electronic
publication. The assigned DOI never changes. Therefore, it is an ideal medium for citing a document, particularly "Articles in press"
because they have not yet received their full bibliographic information. The correct format for citing a DOI is shown as follows (example
taken from a document in the journal Physics Letters B):
doi:10.1016/j.physletb.2003.10.071
When you use the DOI to
create URL hyperlinks to documents on
the web, they are guaranteed never to change.
Footnotes: Footnotes should appear at
the bottom of the appropriate page and be indicated by the following symbols: asterisk, dagger, double dagger, section sign, paragraph,
parallels.
Tables: All tables should be cited in the text, and numbered in order of appearance with Arabic numerals. All table
columns should have a brief explanatory heading and, where appropriate, units of measurement. Vertical lines should not be used. Footnotes
to tables should be typed below the table and should be referred to by superscript letters. Each table should have a descriptive heading,
which, together with the individual column headings, should make the table, as nearly as possible, self-explanatory. In setting up tabulations,
authors are requested to keep in mind the column widths (8.4 cm and 17.7 cm), and to make the table conform to the limitations of these
dimensions.
Legends: Legends for figures and schemes should be grouped together separately.
Artwork: Figures, schemes,
and equations must be cited in the text and numbered in order of appearance with Arabic numerals. Other graphics, such as structures,
do not need to be numbered, but please indicate in the text where these are to appear. All graphics (including chemical structures) must
be provided at the actual size that they are to appear (single-column width is 8.4 cm, double-column width is 17.7 cm). Please arrange
schematics so that they fill the column space (either single or double), so as
not to leave a lot of unused white space. Please ensure
that all illustrations within a paper are consistent in type, quality, and size. Legends should not be included as part of the graphic;
instead all legends should be supplied at the end of the text.
To help authors provide actual size graphics, it is suggested that
the following settings be used with CSC ChemDraw and ISIS Draw: font 10 pt Helvetica, chain angle 120°, bond spacing 18% of length,
fixed length 10.08 pt (0.354 cm), bold width 1.4 pt (0.049 cm), line width 0.42 pt (0.015 cm), margin width 1.12 pt (0.040 cm), and hash
spacing 1.75 pt (0.062 cm). Compound numbers should be in boldface. In order to accurately design schematics to print out at the proper
width, the original drawing cannot exceed a column width of 8.4 cm (for single column) and 17.7 cm (for double column). Layout design
is facilitated if authors submit their original artwork in the actual size to be published. Please save graphics as an Encapsulated PostScript
file (EPS) or a Tagged Image File Format (TIFF), as well as the program the graphic was originally drawn in. For more details on the
preparation and submission of artwork, please visit www.elsevier.com/artworkinstructions.
Colour: Colour figures
should be supplied in electronic format as
JPEG files (minimum 300 dots per inch).
- In print: Colour figures may be printed
in the journal at no charge to the author, provided that the editor considers the colour necessary to convey scientific information.
- On the Web: Any figure can appear free of charge in colour in the Web version of your article (e.g., on ScienceDirect), regardless
of whether or not this is reproduced in colour in the printed version. Please note that if you do not opt for colour in print, you should
submit relevant figures in both colour (for the Web) and black and white (for print).
Cover illustration
Authors are encouraged
to submit interesting figures for possible publication on the front cover of an issue of this journal; the figure should be related to
the author's article.
Journal conventions
Nomenclature: It is the responsibility of the authors to provide correct
nomenclature. Chemical names for drugs are preferred. If these are not practical, generic names, names approved by the U.S. Adopted Names
Council, or those approved by the World Health Organization may be used. If a generic name is used, its chemical name or structure should
be provided at the point of first citation. Authors will find the following as useful reference books for recommended nomenclature.
IUPAC Nomenclature of Organic Chemistry; Rigaudy, J.; Klesney,
S. P., Eds; Pergamon: Oxford, 1979. Enzyme Nomenclature;
Webb, E. C., Ed.; Academic Press;
Orlando, 1992. Biochemical Nomenclature and Related Documents; The
Biochemistry Society;
London, 1978. The ACS Style Guide; Dodd, J. S., Ed.; American Chemical
Society: Washington, DC, 1997.
X-ray crystallographic
data: Prior to submission of the manuscript, the author should deposit crystallographic data for organic and metalorganic structures
with the Cambridge Crystallographic Data Centre. The data, without structure factors, should be sent by e-mail to deposit@ccdc.cam.ac.uk,
as an ASCII file, preferably in CIF format. Hard copy data should be sent to CCDC, 12 Union Road, Cambridge CB2 1EZ. A checklist of data
items for deposition can be obtained from the CCDC Home Page on the World Wide Web (http://www.ccdc.cam.ac.uk) or by e-mail
to: fileserv@ccdc.cam.ac.uk, with the one-line message, send me checklist. The data will be acknowledged, within three
working days, with one CCDC deposition number per structure deposited. These numbers should be included with the following standard text
in the manuscript: Crystallographic data (excluding structure factors) for the structures in this paper have been deposited with the
Cambridge Crystallographic Data Centre as supplementary publication nos. CCDC. Copies of the data can be obtained, free of charge, on
application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK, (fax: +44-(0)1223-336033 or e-mail: deposit@ccdc.cam.ac.Uk).
Deposited data may be accessed by the journal and checked as part of the refereeing process. If data are revised prior to publication,
a replacement file should be sent to CCDC.
Characterization of new compounds: All new compounds should be fully characterized
with relevant spectroscopic data. Microanalyses should be included whenever possible. Under appropriate circumstances, high-resolution
mass spectra may serve in lieu of microanalysis, if accompanied by suitable NMR criteria for sample homogeneity.
DNA sequences
and GenBank Accession numbers: Many Elsevier journals cite "gene accession numbers" in their running text and footnotes. Gene accession
numbers refer to genes or DNA sequences about which further information can be found in the databases at the National Center for Biotechnical
Information (NCBI) at the National Library of Medicine. Elsevier authors wishing to enable other scientists to use the accession numbers
cited in their papers via links to these sources, should type this information in the following manner: For each and every
accession number cited in an article, authors should type the accession number in bold, underlined text. Letters in the
accession number should always be capitalised. (See Example below). This combination of letters and format will enable Elsevier's typesetters
to recognise the relevant texts as accession numbers and add the required link to GenBank's sequences.
Example: "(GenBank
accession nos. AI631510,AI631511, AI632198, and BF223228), a B-cell tumor from
a chronic lymphatic leukemia (GenBank accession no. BE675048), and a T-cell lymphoma (GenBank accession no. AA361117)". Authors are encouraged
to check accession numbers used very carefully. An error in a letter or number can result in a dead link. In the final version
of the printed article, the accession number text will not appear bold or underlined. In the final version of the electronic
copy, the accession number text will be linked to the appropriate source in the NCBI databases enabling readers to go directly to
that source from the article.
Software: Software used as part of computer-aided drug/agent design (e.g., molecular modelling,
QSAR, conformational analysis, molecular dynamics) should be readily available from accepted sources and the authors may specify where
the software can be obtained. Assurance of the quality of the parameters employed for the relevant potential functions should be detailed
in the manuscript.
Preparation of supplementary data: Elsevier accepts electronic supplementary material to support and enhance
your scientific research. Supplementary files offer the author additional possibilities to publish supporting applications, movies, animation
sequences, high-resolution images, background datasets, sound clips, and more. Supplementary files supplied will be published online
alongside the electronic version of your article in Elsevier web products, including ScienceDirect: www.sciencedirect.com.
To ensure that your submitted material is directly usable, please provide data in one of our recommended file formats. Supplementary
data must be saved in files separate from those for the manuscript and figures, and all file names must be supplied. Supplementary files
should either be referred to from within the text of your manuscript in the same way as for figures or tables, or their presence be indicated
by adding a paragraph entitled "Supplementary data" at the end of the manuscript, detailing which data are supplied. In addition, authors
should also provide a concise and descriptive caption for each file.
When supplying supplementary data, authors must state whether
the data files are either (i) for online publication or (ii) to be used as an aid for the refereeing of the paper only. All supplementary
data will be subject to peer review. For more detailed instructions, on supplementary data, please visit our artwork instruction pages
at www.elsevier.com/artworkinstructions.
Proofs
Proofs will be despatched via e-mail and should be returned
with corrections as quickly as possible, normally within 48 hours of receipt. Elsevier now sends PDF proofs which can be annotated; for
this you will need to download Adobe Reader version 7 available free from http://www.adobe.com/products/acrobat/readstep2.html.
Instructions on how to annotate PDF files will accompany the proofs. The exact system requirements are given at the Adobe site: http://www.adobe.com/products/acrobat/acrrsystemreqs.html#70win. If you do not wish to use the PDF annotations function, you may list the corrections (including replies to the Query Form) and return
to Elsevier in an e-mail. Please list your corrections quoting line number. If, for any reason, this is not possible, then mark the corrections
and any other comments (including replies to the Query Form) on a printout of your proof and return by fax, or scan the pages and e-mail,
or by post. Please use this proof only for checking the typesetting, editing, completeness and correctness of the text, tables and figures.
Significant changes to the article as accepted for publication will only be considered at this stage with permission from the Editor.
We will do everything possible to get your article published quickly and accurately. Therefore, it is important to ensure that all of
your corrections are sent back to us in one communication: please check carefully before replying, as inclusion of any subsequent corrections
cannot be guaranteed. Proofreading is solely your responsibility. Note that Elsevier may proceed with the publication of your article
if no response is received. Any amendments will be incorporated and the final article will then be published online as an Article in
Press on ScienceDirect (www.sciencedirect.com).
Articles in Press take full advantage of the enhanced Science-Direct
functionality, including the ability to be cited. This is possible due to the innovative use of the DOI article identifier, which enables
the citation of a paper before volume, issue and page numbers are allocated. The Article in Press will be removed once the paper has
been assigned to an issue and the issue has been compiled.
Electronic offprints (e-offprints)
The corresponding author,
at no cost, will be provided with a PDF file of the article via e-mail or, alternatively, 25 free paper offprints. The PDF file is a
watermarked version of the published article and includes a cover sheet with the journal cover image and a disclaimer outlining the terms
and conditions of use. Additional paper offprints can be ordered by the authors. An order form with prices will be sent to the corresponding
author.
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None.
Author benefits
Contributors to Elsevier journals are entitled to a 30% discount
on all Elsevier books.
Other inquiries
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