Guide for Authors

Official Journal of the European Proteomics Association (EuPA)
Former title: Journal of Biochemical and Biophysical Methods



- Types of paper - Page charges
BEFORE YOU BEGIN
Ethics in Publishing - Policy and ethics - Conflict of interest - Submission declaration - Authorship - Copyright - Retained author rights - Role of the funding source - Funding body agreements and policies - Language and language services - Submission - Referees - Use of wordprocessing software - Manuscript Layout - - - Accession numbers - Electronic artwork - Tables - References - Citaiton in Text - Supplementary material - Submission checklist
AFTER ACCEPTANCE
Offprints - Appendix
AUTHOR INQUIRIES

The Journal of Proteomics covers all areas of applied and basic research in Proteomics using multi-disciplinary approaches to unravel biological processes. Emphasis is placed on translational research and biomarker discovery in human, animal, micro-organism and plant systems. The journal provides a forum for activities in proteomics and helps strengthen the links between research scientists all over the world.

In addition to original papers, the journal publishes frequent review and update papers, letters to the editor, book reviews, reports and news as well as Proceedings of EuPA national congress. The journal also publishes the official EuPA guidelines papers.

The following types of paper are published:

Original Articles: Original articles are the normal medium of publication. Although there is no fixed length, articles should be as concise as possible, while providing sufficient information for the work to be repeated and for the claims of the authors to be judged by the readers.

Reviews: These are contributed by scientists who are leading specialists in their field of expertise, normally at the invitation of the Editors. Authors wishing to contribute a review paper are advised first to contact one of the responsible Editors (listed in the issues of Journal of Proteomics to avoid overlap with Reviews already commissioned.)

Technical reports: Technical reports should present brief descriptions of novel apparatus, a new experimental or computational method, test or procedure, or an improvement or noteworthy modification of an already existing technique or platform used in the proteomic workflow. Technical reports should show a realistic application of the methodology described. Theoretical papers dealing with mechanistic aspects of proteomic techniques will also be considered. A technical report should be a short (no more than two pages when published) description written in a continuous style with no more than two figures and one table.

News & Views: News & Views point out the author(s) vision of the character and importance of a new direction in proteome research. They are not intended to be accounts or analyses of an individual's personal research. Although News & Views will usually be invited, they can be submitted without invitation. Author(s) are encouraged to suggest experts in the field who can act as reviewers.

Letters to the Editor: Letters to the Editor are intended to stimulate discussion and debate in areas of general concern and controversy in proteomics, and generally reflect the personal opinions of the author(s). They should be written in a continuous style and should normally not exceed two printed pages and contain no more than one figure or table.

Types of paper

Page charges

This journal has no page charges.

BEFORE YOU BEGIN

Ethics in Publishing

For information on Ethics in Publishing and Ethical guidelines for journal publication see http://www.elsevier.com/publishingethics and http://www.elsevier.com/ethicalguidelines.

Policy and ethics

The work described in your article must have been carried out in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki) for experiments involving humans http://www.wma.net/e/policy/b3.htm; EC Directive 86/609/EEC for animal experiments http://ec.europa.eu/environment/chemicals/lab_animals/legislation_en.htm; Uniform Requirements for manuscripts submitted to Biomedical journals http://www.nejm.org/general/text/requirements/1.htm. This must be stated at an appropriate point in the article.

Conflict of interest

All authors are requested to disclose any actual or potential conflict of interest including any financial, personal or other relationships with other people or organizations within three years of beginning the submitted work that could inappropriately influence, or be perceived to influence, their work. See also http://www.elsevier.com/conflictsofinterest.

Submission declaration

Submission of an article implies that the work described has not been published previously (except in the form of an abstract or as part of a published lecture or academic thesis), that it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published elsewhere in the same form, in English or in any other language, without the written consent of the copyright-holder.

Authorship

All authors should have made substantial contributions to all of the following: (1) the conception and design of the study, or acquisition of data, or analysis and interpretation of data, (2) drafting the article or revising it critically for important intellectual content, (3) final approval of the version to be submitted.

Copyright

Upon acceptance of an article, authors will be asked to complete a 'Journal Publishing Agreement' (for more information on this and copyright see http://www.elsevier.com/copyright). Acceptance of the agreement will ensure the widest possible dissemination of information. An e-mail will be sent to the corresponding author confirming receipt of the manuscript together with a 'Journal Publishing Agreement' form or a link to the online version of this agreement.
Subscribers may reproduce tables of contents or prepare lists of articles including abstracts for internal circulation within their institutions. Permission of the Publisher is required for resale or distribution outside the institution and for all other derivative works, including compilations and translations (please consult http://www.elsevier.com/permissions). If excerpts from other copyrighted works are included, the author(s) must obtain written permission from the copyright owners and credit the source(s) in the article. Elsevier has preprinted forms for use by authors in these cases: please consult http://www.elsevier.com/permissions.

Retained author rights

As an author you (or your employer or institution) retain certain rights; for details you are referred to: http://www.elsevier.com/authorsrights.

Role of the funding source

You are requested to identify who provided financial support for the conduct of the research and/or preparation of the article and to briefly describe the role of the sponsor(s), if any, in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. If the funding source(s) had no such involvement then this should be stated. Please see http://www.elsevier.com/funding.

Funding body agreements and policies

Elsevier has established agreements and developed policies to allow authors whose articles appear in journals published by Elsevier, to comply with potential manuscript archiving requirements as specified as conditions of their grant awards. To learn more about existing agreements and policies please visit http://www.elsevier.com/fundingbodies.

Language and language services

Please write your text in good English (American or British usage is accepted, but not a mixture of these). Authors who require information about language editing and copyediting services pre- and post-submission please visit http://www.elsevier.com/languagepolishing or our customer support site at http://epsupport.elsevier.com for more information. Please note Elsevier neither endorses nor takes responsibility for any products, goods or services offered by outside vendors through our services or in any advertising. For more information please refer to our Terms & Conditions: http://www.elsevier.com/termsandconditions.

Submission

Submission to this journal proceeds totally online and you will be guided stepwise through the creation and uploading of your files. The system automatically converts source files to a single PDF file of the article, which is used in the peer-review process. Please note that even though manuscript source files are converted to PDF files at submission for the review process, these source files are needed for further processing after acceptance. All correspondence, including notification of the Editor's decision and requests for revision, takes place by e-mail removing the need for a paper trail.

Referees

Please provide the names and addresses of 4 - 5 suitable potential reviewers. If there are compelling reasons for excluding some individuals as potential reviewers, these can be mentioned. However, choice of reviewers is at the Editors' discretion.

Use of wordprocessing software

It is important that the file be saved in the native format of the wordprocessor used. The text should be in single-column format. Keep the layout of the text as simple as possible. Most formatting codes will be removed and replaced on processing the article. In particular, do not use the wordprocessor's options to justify text or to hyphenate words. However, do use bold face, italics, subscripts, superscripts etc. Do not embed "graphically designed" equations or tables, but prepare these using the wordprocessor's facility. When preparing tables, if you are using a table grid, use only one grid for each individual table and not a grid for each row. If no grid is used, use tabs, not spaces, to align columns. The electronic text should be prepared in a way very similar to that of conventional manuscripts (see also the Guide to Publishing with Elsevier: http://www.elsevier.com/guidepublication). Do not import the figures into the text file but, instead, indicate their approximate locations directly in the electronic text and on the manuscript. See also the section on Electronic illustrations.
To avoid unnecessary errors you are strongly advised to use the "spell-check" and "grammar-check" functions of your wordprocessor.

Manuscript Layout

Authors should consult a recent issue of the journal to make themselves familiar with the conventions and layout of articles.

The entire text, including figure and table legends and the reference list, should be double-spaced, leaving a left margin of approx. 3 cm. All pages should be numbered consecutively, starting with the title page of the manuscript. Every new paragraph should be clearly indented. Expressions of Latin origin, for example, in vivo, in vitro, et al., per se should be typed in normal typeface. They should be neither italicized nor underlined.

Equations
Equations should be numbered in the right margin as follows:

A+B C+D(1)

Structural formulae
Structural formulae should be drawn in the manuscript in the position where they belong. They must be numbered in consecutive order with the other figures.

Abbreviations
The use of abbreviations should be kept to a minimum as it often detracts from clearer understanding of your paper by any reader not working directly in your field, and also by abstracting services and search engines. Therefore, their use should be restricted to a minimum. Abbreviations should be introduced only when repeatedly used. Abbreviations used only in a table or a figure may be defined in the legend. Standard abbreviations, as mentioned in the Appendix to this Guide to Authors may be used in the title, keywords and throughout all articles published, without explanation or definition. If non-standard abbreviations are used in the Abstract they should be defined in the Abstract, in the list of abbreviations of the manuscript, as well as when first used in the body of the paper.

Title page
The title should be concise, descriptive and informative. The names of the authors should be followed by their addresses and indicated by corresponding letters. Changes in address should be indicated by footnotes. The author(s) to whom correspondence and proofs should be sent should be indicated, giving a full address (including fax number and e-mail address).

Keywords
Authors are requested to select a maximum of six key words and to present them on the title page. They should cover precisely the contents of the submitted paper and should give readers sufficient information as to the relevance of the paper to his/her particular field.

Abstract
The second page should be reserved for the Abstract. This should be self-explanatory and intelligible without reference to the body of the paper. Typically papers should have an Abstract of 100-200 words. Since abstracts alone are increasingly used by indexing services which will cut off after a fixed number of words, it is important not to exceed the maximum number of words and to exclude bibliographic references and non-standard abbreviations. Abstracts are required for original articles, reviews and technical reports.

Graphical abstract
Authors must supply a graphical abstract for all Research articles and Reviews at the time the paper is submitted. The abstract should summarize the contents of the paper in a concise, pictorial form designed to capture the attention of a wide readership and for compilation of databases. Carefully drawn figures that serve to illustrate the theme of the paper are desired. Authors may also provide appropriate text, not exceeding 30 words. The content of the graphical abstract will be typeset and should be kept within an area of 5 cm by 17 cm. Authors must supply the graphic separately as an electronic file. For examples of graphical abstracts, please visit the home page of Journal of Controlled Release at http://www.sciencedirect.com/science/journal/01683659

Original articles are usually divided into the sections Introduction, Materials and methods,
Results, Discussion and Conclusions:

Introduction
This is a short section in which the authors should state the reasons for performing the work, with brief reference to relevant previous work.

Material and methods
Provide sufficient detail to allow the work to be reproduced. Methods already published should be indicated by a reference: only relevant modifications should be described.

Results
Results should be clear and concise.

Discussions
This should explore the significance of the results of the work, not repeat them. A combined Results and Discussion section is often appropriate. Avoid extensive citations and discussion of published literature.

Conclusions
The main conclusions of the study may be presented in a short Conclusions section, which may stand alone or form a subsection of a Discussion or Results and Discussion section.

(Technical reports, News & Views, Letters to the Editor: These types of papers are not divided into sections after the summary, except for the reference list. The first paragraph serves as an introduction; acknowledgments are added as a final paragraph before the reference list.)

Experimental design data analysis for 2-D PAGE and MS-based experiments:
The experimental design must be provided and must include details of the number of biological and analytical replicates. Only one biological/analytical replicate will not be acceptable. In clinical studies, it is highly desirable that a power analysis predicting the appropriate sample size for subsequent statistical analysis of the data is carried out.

For expression analysis studies, summary statistics (mean, standard deviation) must be provided and results of statistical analysis must be shown. Reporting fold differences alone is not acceptable.

Authors must report the following: methods of data normalization, transformation, missing value handling, the statistical tests used, the degrees of freedom and the statistical package or program used. Where biologically important differences in protein (gene) expression are reported, confirmatory data (e.g. from Western blot, RT-PCR analysis, etc.) are desirable. For biomarker discovery/validation studies, the sensitivity and specificity of the biomarker(s) should be provided wherever possible. It is desirable that receiver operator characteristic (ROC) curves and areas under the curves are given. The method(s) used to generate the mass spectrometry data must be described. The name and version of the program used for database searching, the values of critical search parameters (e.g. the mass over charge (m/z) and the charge (z) of the precursor ion, fragment mass tolerance, cleavage rules used, allowance for number of missed cleavages and modifications) and the name and version of the database(s) searched must be provided. For each protein identified, measures of certainty (e.g. p-values) must be provided. For MS/MS, the number of peptides used to identify a protein must be given as well as the sequence and charge state of each peptide.

Identification of proteins based solely on mass fingerprinting will be considered only if the sequence of the genome of the organism under study is known. For peptide mass fingerprinting, the number of peptides that match the sequence, the number of unmatched peaks, and the total percent of sequence coverage must be quoted. If extensive, the above information should be submitted as Supplemental Information (see below). In order to reduce the possibility of false-positive hits, whenever possible, authors are advised to verify the mass fingerprint assignment of at least one peptide ion by MS/MS sequencing. Identification of proteins from organisms with unknown genome sequence will be accepted only if MS/MS-derived peptide sequence data have been used
database searching or BLAST analysis. The score for the highest ranked hit to an homologous, orthologous, or paralogous protein should be indicated.

For experiments with large MS/MS data sets, estimates of the false positive rates are required (e.g. through searching randomized or reversed sequence databases). This information should be provided as supporting information. Where post-translational modifications are reported, the methods used to discover the modification must be described. The modification should be mapped to amino acid(s) by fragmentation analysis, but reported as ambiguous if mapping to a single amino acid is not possible. For isobaric modifications, evidence for assigning a specific modification must be provided and the spectra included as supporting information. Where protein sequence isoforms are reported, the peptide sequence that matches the unique amino acid sequence of a particular isoform must be provided. Fragmentation analysis of the appropriate peptides should be described.

Accession numbers

Accession numbers are unique identifiers in bioinformatics allocated to nucleotide and protein sequences to allow tracking of different versions of that sequence record and the associated sequence in a data repository [e.g., databases at the National Center for Biotechnical Information (NCBI) at the National Library of Medicine ('GenBank') and the Worldwide Protein Data Bank]. There are different types of accession numbers in use based on the type of sequence cited, each of which uses a different coding. Authors should explicitly mention the type of accession number together with the actual number, bearing in mind that an error in a letter or number can result in a dead link in the online version of the article. Please use the following format: accession number type ID: xxxx (e.g., MMDB ID: 12345; PDB ID: 1TUP). Note that in the final version of the electronic copy, accession numbers will be linked to the appropriate database, enabling readers to go directly to that source from the article.

Electronic artwork

General points
• Make sure you use uniform lettering and sizing of your original artwork.
• Save text in illustrations as "graphics" or enclose the font.
• Only use the following fonts in your illustrations: Arial, Courier, Times, Symbol.
• Number the illustrations according to their sequence in the text.
• Use a logical naming convention for your artwork files.
• Provide captions to illustrations separately.
• Produce images near to the desired size of the printed version.
• Submit each figure as a separate file.

A detailed guide on electronic artwork is available on our website:
http://www.elsevier.com/artworkinstructions
You are urged to visit this site; some excerpts from the detailed information are given here.
Formats
Regardless of the application used, when your electronic artwork is finalised, please "save as" or convert the images to one of the following formats (note the resolution requirements for line drawings, halftones, and line/halftone combinations given below):
EPS: Vector drawings. Embed the font or save the text as "graphics".
TIFF: color or grayscale photographs (halftones): always use a minimum of 300 dpi.
TIFF: Bitmapped line drawings: use a minimum of 1000 dpi.
TIFF: Combinations bitmapped line/half-tone (color or grayscale): a minimum of 500 dpi is required.
DOC, XLS or PPT: If your electronic artwork is created in any of these Microsoft Office applications please supply "as is".
Please do not:
• Supply embedded graphics in your wordprocessor (spreadsheet, presentation) document;
• Supply files that are optimised for screen use (like GIF, BMP, PICT, WPG); the resolution is too low;
• Supply files that are too low in resolution;
• Submit graphics that are disproportionately large for the content.

Color artwork
Please make sure that artwork files are in an acceptable format (TIFF, EPS or MS Office files) and with the correct resolution. If, together with your accepted article, you submit usable color figures then Elsevier will ensure, at no additional charge, that these figures will appear in color on the Web (e.g., ScienceDirect and other sites) regardless of whether or not these illustrations are reproduced in color in the printed version. For color reproduction in print, you will receive information regarding the costs from Elsevier after receipt of your accepted article. Please indicate your preference for color in print or on the Web only. For further information on the preparation of electronic artwork, please see Please note: Because of technical complications which can arise by converting color figures to "gray scale" (for the printed version should you not opt for color in print) please submit in addition usable black and white versions of all the color illustrations.

Figure captions
Ensure that each illustration has a caption. Supply captions separately, not attached to the figure. A caption should comprise a brief title (not on the figure itself) and a description of the illustration. Keep text in the illustrations themselves to a minimum but explain all symbols and abbreviations used.

Tables

Number tables consecutively in accordance with their appearance in the text. Place footnotes to tables below the table body and indicate them with superscript lowercase letters. Avoid vertical rules. Be sparing in the use of tables and ensure that the data presented in tables do not duplicate results described elsewhere in the article.

References

Citaiton in Text

The numerical system of references should be used. References in the text should be cited by numbers in square brackets in the order of their citation.

References are listed together in their order of appearance in a separate section at the end of the text under the heading References. All references should be numbered consecutively. References to journals should contain initials and names of all authors, article title, abbreviation of the name of the journal according to the List of Serial Title World Abbreviations (International Series Data System, 20, rue Bachaumont, 75002 Paris, France. ISBN 2-904938-02-8), year of publication, volume number, and page numbers. References to books should also include the title (of series and volumes), initials and names of the editor(s), the publisher and place of publication.

Examples:

Reference to a journal publication:
[1] Resing KA, Ahn NG. Proteomics strategies for protein identification. FEBS Letters 2005;579:885-9.

Reference to a book:
[2] Rehm H. Protein Biochemistry and Proteomics. San Diego: Academic Press/Elsevier Inc; 2006.

Reference to a chapter in an edited book or book series:
[3] Morgan JW, Hettick JM, Russell DH. Peptide sequencing by MALDI 193-nm photodissociation TOF MS. In: Burlingame AL, editor. Methods in Enzymology, vol 402: Biological Mass Spectrometry. San Diego: Academic Press/Elsevier Inc; 2005, p.186-209.

Reference to a paper as "in press" implies that it has been accepted for publication. Evidence (e.g., a photocopy of the note of acceptance from the journal concerned) should accompany the submitted typescript. Papers that are "in press" should be included as a number in the text. Other papers submitted before or simultaneously with the paper in question should be included as a number in the text and in the References section, stating the name of the journal. Copies of papers that are submitted elsewhere should be provided for inspection by the Editors. Omission of this information will delay publication and may lead to redating of a submitted manuscript. Papers presented at scientific meetings that are not available in published form should not be cited as references in the References section.

Unpublished results should not be listed in the References section. In the text they are mentioned as follows: "(Tervoort MV and Glimcher J, unpublished data)". When unpublished results are cited, the data should be provided for the Editors' information when essential for proper evaluation, or if requested.

A personal communication should be mentioned in the text as follows: "(Tervoort MV, personal communication)". Authors should not make unauthorized use of personal communications. Personal communications are not to be included in the Reference section.

Supplementary material

Elsevier accepts electronic supplementary material to support and enhance your scientific research. Supplementary files offer the author additional possibilities to publish supporting applications, movies, animation sequences, high-resolution images, background datasets, sound clips and more. Supplementary files supplied will be published online alongside the electronic version of your article in Elsevier Web products, including ScienceDirect: http://www.sciencedirect.com. In order to ensure that your submitted material is directly usable, please ensure that data are provided in one of our recommended file formats. Authors should submit the material in electronic format together with the article and supply a concise and descriptive caption for each file. Video files: please supply 'stills' with your files: you can choose any frame from the video or make a separate image. These will be used instead of standard icons and will personalize the link to your supplementary information. For more detailed instructions please visit our artwork instruction pages at http://www.elsevier.com/artworkinstructions.

Submission checklist

It is hoped that this list will be useful during the final checking of an article prior to sending it to the journal's Editor for review. Please consult this Guide for Authors for further details of any item.
Ensure that the following items are present:
One Author designated as corresponding Author:
• E-mail address
• Full postal address
• Telephone and fax numbers
All necessary files have been uploaded
• Keywords
• All figure captions
• All tables (including title, description, footnotes)
Further considerations
• Manuscript has been "spellchecked" and "grammar-checked"
• References are in the correct format for this journal
• All references mentioned in the Reference list are cited in the text, and vice versa
• Permission has been obtained for use of copyrighted material from other sources (including the Web)
• color figures are clearly marked as being intended for color reproduction on the Web (free of charge) and in print or to be reproduced in color on the Web (free of charge) and in black-and-white in print
• If only color on the Web is required, black and white versions of the figures are also supplied for printing purposes
For any further information please visit our customer support site at http://epsupport.elsevier.com.

AFTER ACCEPTANCE

Offprints

The corresponding author, at no cost, will be provided with a PDF file of the article via e-mail. The PDF file is a watermarked version of the published article and includes a cover sheet with the journal cover image and a disclaimer outlining the terms and conditions of use.

Appendix

Standard abbreviations allowed to be used without explanation or definition in all articles published in the Journal of Proteomics. A absorbance ACES 2-[(2-amino-2-oxoethyl)amino] ethanesulphonic acid CAN acetonitrile A/D analog to digital converter AEBSF 4-(2-aminoethyl)benzenesulphonyl fluoride amu atomic mass unit ANOVA analysis of variance API atmospheric pressure ionization
AUC area under curve
Bis N,N'-methylenebisacrylamide
bp base pairs
BSA bovine serum albumin
%C cross-linking agent (g/100 mL)/%T
CAPS 3-(cyclohexylamino)-1-propanesulphonic acid
CBB Coomassie Brilliant Blue
CCD charge-coupled device
CD circular dicroism
CE capillary electrophoresis
CEC capillary electrochromatography
CFE continuous flow electrophoresis
CHAPS 3-[(3-cholamidopropyl)dimethylamonio]-1-propanesulphonate
CHCA ?-cyano-4-hydroxycinnamic acid
CHES 2-(N-cyclohexylamino)ethanesulphonic acid
CID collision-induced dissociation
CIEF capillary isoelectric focusing
CMC critical micelle concentration
Con A Concanavalin A
CNS central nervous system
cpm counts per minute
CTAB etyltrimethylammonium bromide
CV coefficient of variation
CZE capillary zone electrophoresis
1-D one-dimensional
2-D two-dimensional
Da dalton (molecular mass)
2-DE two-dimensional electrophoresis
DIGE fluorescence difference gel electrophoresis
DGGE denaturing gradient gel electrophoresis
DMEM Dulbecco's modified Eagle medium
DMF N,N-dimethylformamide
DMSO dimethyl sulphoxide
DOC sodium deoxycholate
dsDNA double-stranded DNA
DTE dithioerithriol
DTT dithiothreitol
ECL enhanced chemiluminescence
EDTA ethylenediaminetetraacetic acid
EEO electroendosmosis
EGTA ethylene glycol-bis(?-aminoethylether)-N,N,N',N'-tetraacetic acid
EKC electrokinetic chromatography
ELISA enzyme-linked immunosorbent assay
EMSA electrophoretic mobility shift assay
EOF electroosmotic flow
ER endoplasmic reticulum
ESI electrospray ionization
EST expressed sequence tag
EUPA European Proteome Association
FAB fast atom bombardment
FACS fluorescence activated cell sorting
FBS fetal bovine serum
FCS fetal calf serum
FIGE field inversion gel electrophoresis
FITC fluorescein isothiocyanate
FT Fourier transform
FT-ICR Fourier transform-ion cyclotron resonance
GC gas chromatography
GIF graphic interchange format
GRAVY grand average hydrophobicity
GSH glutathione
GST glutathione-S-transferase
HE hematoxylin and eosin
HEPES N-(2-hydroxyethyl)piperazine-2'-(2-ethanesulphonic acid)
HPCE high-performance capillary electrophoresis
HPLC high-performance liquid chromatography
HRP horseradish peroxidase
HSA human serum albumin
HSP heat shock protein
HTML hypertext mark-up language
HUPO Human Proteome Organisation
HVR hypervariable region
ICAT isotop-coded affinity tag
ICR ion cyclotron resonance
id inside diameter
IEF isoelectric focusing
Ig immunoglobulin
IMAC immobilized metal affinity capture
IPG immobilized pH gradient
IT ion trap
iTRAQ isobaric tag for relative and absolute quantitation
kbp kilobase pairs
kDa kilodalton (molecular mass)
LC liquid chromatography
LED light-emitting diode
LOD limit of detection
LOQ limit of quantitation
mAb monoclonal antibody
MALDI-MS matrix-assisted laser-desorption ionization-mass spectrometry
Mbp megabase pairs
MEKC micellar electrokinetic capillary chromatography
MES 2-(N-morpholino)ethanesulphonic acid
MHC

AUTHOR INQUIRIES

For inquiries relating to the submission of articles (including electronic submission where available) please visit this journal's homepage. You can track accepted articles at http://www.elsevier.com/trackarticle and set up e-mail alerts to inform you of when an article's status has changed. Also accessible from here is information on copyright, frequently asked questions and more. Contact details for questions arising after acceptance of an article, especially those relating to proofs, will be provided by the publisher.