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Nuclear Medicine and Biology
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ISSN: 0969-8051
Imprint: ELSEVIER
Nuclear Medicine and Biology publishes original research addressing all aspects of
radiopharmaceutical
science: synthesis, in vitro and ex vivo studies, in vivo biodistribution by
dissection or imaging, radiopharmacology, radiopharmacy,
and translational clinical studies of
targeted radiotracers. The importance of the target to a key disease ... click here for full Aims & Scope
Nuclear Medicine and Biology publishes original research addressing all aspects of
radiopharmaceutical
science: synthesis, in vitro and ex vivo studies, in vivo biodistribution by
dissection or imaging, radiopharmacology, radiopharmacy,
and translational clinical studies of
targeted radiotracers. The importance of the target to a key disease should be the first
consideration.
If the synthesis of a new radiopharmaceutical is submitted without in vitro or in
vivo data, then the uniqueness of the chemistry must
be emphasized.
These multidisciplinary studies should validate the mechanism of localization whether the
probe is based on binding
to a receptor, enzyme, tumor antigen, or another well-defined target.
The studies should be aimed at evaluating how the chemical and
radiopharmaceutical
properties affect pharmacokinetics, pharmacodynamics, or therapeutic efficacy. Ideally, the
study would address the
sensitivity of the probe to changes in disease or treatment, although
studies validating mechanism alone are acceptable. Radiopharmacy
practice, addressing the
issues of preparation, automation, quality control, dispensing, and regulations applicable to
qualification
and administration of radiopharmaceuticals to humans, is an important aspect of the
developmental process, but only if the study has
a significant impact on the field.
Contributions on the subject of therapeutic radiopharmaceuticals also are appropriate provided
that
the specificity of labeled compound localization and therapeutic effect have been addressed.
Supplemental information on the Aims and
Scope can be found in the Jan issue of the Journal
and at  www.nucmedbio.com.
Hide Aims & Scope
Editor-in-Chief: Contact the Editor
William C. Eckelman, PhD
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