SUBMISSION OF MANUSCRIPTS
Articles must be submitted electronically using the Elsevier Editorial System (EES). EES is a web-based
system with full online submission, review and status update capabilities. EES allows you to upload files directly from your computer.
You may access EES at http://www.ees.elsevier.com/lfs/ If you are
using EES for the first time, you must register before you submit a paper. To do so, please click on "Submit Paper", then "Not
Yet Registered", to begin the registration process.
Following submission, the article is assigned to either the European or U.S. Office. Neither office accepts hard copy submissions.
Specific queries can be directed to lifesci@elsevier.com.
IMPORTANT INFORMATION
1. Submission of a paper
will be held to imply that the manuscript contains original unpublished work and is not being submitted for publication elsewhere.
2. Manuscripts submitted under multiple authorship are reviewed on the assumption that all listed authors concur with the submission
and that a copy of the final manuscript has been approved by all authors and tacitly or explicitly by the responsible authorities in
the laboratories where the work was carried out.
3. It is understood that with submission of this article the authors have complied
with the institutional policies governing the humane and ethical treatment of the experimental subjects, and that they are willing to
share the original data and materials if so requested.
4. Conflict of Interest/Full Disclosure: In addition to complete contact/address
of employer/institutional affiliation for all authors, all other relationships that may be perceived to potentially conflict the objectivity
of any author must be fully disclosed in a footnote to the manuscript.
Suggested Referees: To expedite the review process,
authors must submit names of 4 - 6 individuals who are qualified to review their work. Include the email address of each potential referee,
as much contact information as possible, and why you feel this person is competent to review your work. You should not have collaborated
with the suggested reviewers at any time in the past five years. In our effort to enhance global perspective and communication of science,
these individuals should be associated with institutions from as many different regions as possible (Europe, North America, Asia, etc.).
Exception: Symposium submissions which have been previously reviewed and approved by their Organizing Committee.
FORMATTING INSTRUCTIONS
1. Prepare the text in Microsoft Word in order to prevent conversion errors.
2. Use double line spacing with no paragraph indents.
3. All manuscript pages should be numbered.
4. Use the word-processor's word-wrap feature. Use hard returns only at the end of paragraphs.
5. Do not italicize common Latin terms (i.e., in vivo, in vitro, et al., ad libitum).
ORGANIZATION OF THE MANUSCRIPT
Beginning
with the first page, present your manuscript in the order below:
1. Title: First letter capitalized, subsequent letters in lower
case. Maximum length 150 characters including spaces. Avoid abbreviations.
2. Name, institutional affiliation and complete address
of each author.
3. Author to whom proofs and correspondence should be sent, including name, mailing address, telephone and fax numbers,
and e-mail address.
4. Structured abstract of no more than 250 words. The following headings must be used:
Aims:
Main methods:
Key findings:
Significance:
5. Three or more key words for indexing purposes. In addition to key words from the title, please
suggest other terms that help define the study. We encourage authors to test the relevance of their key words by using them for a database
search and comparing the results with the topic of their own paper.
Headings: Papers must include the major headings Abstract,
Introduction, Materials and Methods, Results,
Discussion, Conclusion, Acknowledgments, and References. Include subheadings as appropriate.
Review articles
must contain Abstract and Introduction, with subsequent headings and subheadings as appropriate.
Word limits:
In full papers, individual sections should be no longer than Abstract 250 words, Introduction 500 words, Discussion 1500 words,
Conclusion 150 words. Materials and Methods and Results sections should be concise but there is no formal word limit. Review articles
should be no longer than 8000 words.
Figures, Figure Legends and Tables: Placement of figures and tables will be determined
by the printer at the time of publication; do not indicate where they appear in the text. Upload figures and tables where indicated on
the Attach Files page of EES. Lettering in figures should be in one of the fonts Arial, Courier, Helvetica, Symbol or Times. Avoid using
patterns in histograms/bar graphs. Solid white/gray/black bars are preferred. Do not import figures into the manuscript file. Figures
composed of many similar panels should be submitted both in compiled form for review and as separate high-resolution images for production.
Tables must be submitted in word processing format, not as images. Figure and table legends are considered part of the manuscript and
should appear following References. For information on the preparation of electronic artwork, please see "Artwork instructions"
under http://www.elsevier.com/artworkinstructions.
Reproduction of Color Photographs: The publisher will publish
your color artwork on the Web (e.g. Science Direct and other sites) at no additional cost - regardless of whether the artwork appears
in color or black & white in print. For cost of color reproduction in print, you will receive information from Elsevier after your
article has been accepted.
Funding Acknowledgment This information must appear under the Acknowledgments heading.
References:
References may contain only published works and papers in press. Manuscripts submitted but not yet accepted, unpublished observations
and personal communications may be acknowledged (in parentheses) in the text (including year).
Text citations
− Single author (Smith 2003) − Two authors (Smith and Thompson 2003) − Three or more authors (Smith et al.
2003) (N.B.: note period after et al.) − Multiple references (Smith et al. 2003; Jones et al. 2003) (N.B.: note semicolon)
− Same author(s), same year (Smith and Thompson 2000a,b,c) − Same author(s), different years (Smith et al. 1999, 2001)
Reference list
List references alphabetically. Include the full title of the article referred to, capitalizing only the
initial letter of the title. Spell out all words in journal titles. All major words in journal titles should be capitalized. Sample references:
Journal articles: Feldman RD, Gros R. New insights into the regulation of cAMP synthesis beyond GPCR/G protein activation:
Implications in cardiovascular regulation. Life Sciences 81(4), 267-271, 2007
Books: Strunk W Jr, White EB. The Elements
of Style, third ed. MacMillan, New York (Chapter 4), 1979
Articles or chapters in edited books: Zhang SS, Bruneau
BG. Transcriptional control of the cardiac conduction system (Chapter 10). In: Bodmer R (Ed) Cardiovascular Development, Advances in
Developmental Biology, Vol 18. Elsevier, Amsterdam/Oxford, pp 219-258, 2008
Articles published on the Internet: Kuiper
JWP, Pluk H, Oerlemans F, van Leeuwen FN, de Lange F, Fransen J, Wieringa B. Creatine kinase-mediated ATP supply fuels actin-based events
in phagocytosis. PLoS Biology 6(3) doi:10.1371/journal.pbio.0060051, 2008
Articles from conferences: Cooke JP. Angiogenesis
and the role of the endothelial nicotinic acetylcholine receptor. In: Grando SA, Kawashima K, Kirkpatrick CJ, Wessler I (Eds) Proceedings
of the Second International Symposium on Non-neuronal Acetylcholine, Mainz, Germany, August 31-September 2, 2006. Life Sciences 80(24/25),
2347-2351, 2007
Articles in Special Issues: Please ensure that the words "this issue" are added (in the
list and text) to any references to other articles in the Special Issue.
ABBREVIATIONS
Abbreviations must be explained
the first time they are used, both in the Abstract and again in the main text.
Abbreviations used as names of cell lines do not need
to be explained, but the species and tissue of origin should be made clear in text the first time the cell line is mentioned. Examples: "the human colonic adenocarcinoma cell line Caco-2" or "the porcine renal endothelial cell line LLC-PK1".
When
the manuscript has been reviewed, revised if necessary and accepted:
COPYRIGHT AGREEMENT AND OFFPRINT ORDER FORM
A Transfer of Copyright Agreement and an Offprint Order Form will be sent to the corresponding author by Elsevier when the article begins
the final production process.
AUTHOR PROOFS
Author proofs will be sent in .pdf format to the corresponding author. Return
corrections to the publisher in one communication. Once your corrections have been submitted, it is not possible to incorporate later
changes. Our goal is to publish articles in Life Sciences as quickly as possible, thus we request return of corrections to proofs
within 24 hours of receipt.
US National Institutes of Health (NIH) voluntary posting ("Public Access") policy.
Elsevier
facilitates author response to the NIH voluntary posting request (referred to as the NIH "Public Access Policy"; see http://www.nih.gov/about/publicaccess/index.htm)
by posting the peer-reviewed author's manuscript directly to PubMed Central on request from the author, 12 months after formal publication.
Upon notification from Elsevier of acceptance, we will ask you to confirm via e-mail (by e-mailing us at NIHauthorrequest@elsevier.com)
that your work has received NIH funding and that you intend to respond to the NIH policy request, along with your NIH award number to
facilitate processing. Upon such confirmation, Elsevier will submit to PubMed Central on your behalf a version of your manuscript that
will include your changes made in response to peer-review comments, for posting 12 months after formal publication. This will ensure
that you will have responded fully to the NIH request policy. There will be no need for you to post your manuscript directly with PubMed
Central, and any such posting is prohibited.
