Guide for Authors
Cellular
Signalling publishes full-length, original papers, written in a concise style, that describe key, novel findings on all aspects of mechanisms,
actions and structural components of cellular signalling systems. The emphasis is on:
• effector systems, such as protein kinases,
lipid signalling pathways, cyclic nucleotide signalling processes, NO signalling and ion channels;
• the production, regulation,
degradation and action of second messengers; the structure, regulation, degradation and action of receptors;
• guanine nucleotide
regulatory proteins;
• bio-informatic studies related to cell signalling mechanisms;
• compartmentalisation/compartmentation
of signalling systems;
• anchor/scaffold signalling proteins;
• the effect of cellular signalling events on the functioning,
growth and differentiation of cells in normal and pathological states and also cellular oncogenes.
Within the scope of the journal,
manuscripts dealing with biochemistry, protein structure, cell biology, molecular biology, pharmacology, neurobiology, molecular endocrinology
and molecular oncology are welcomed.
The journal does not publish short reports.
Cellular Signalling will also publish Topical
Reviews of some five thousand to eight thousand words. In general, reviews will be solicited by the Editorial Board. However, intending
contributors of unsolicited review articles can send a brief summary of their proposed Topical Review to the Editorial Office for comment
on its possible acceptability prior to submission.
Cellular Signalling will endeavour to give authors as rapid a decision as possible
concerning the acceptability of their manuscript. Final decisions concerning acceptability will be made both on the novelty of the work,
its scientific content and appropriateness to the remit of the journal.
Should Authors be requested by the Editor to revise the text,
the revised version should be submitted within eight weeks. After this period, the article will be regarded as a new submission.
Types of paper
Cellular Signalling will accept:
• Full-length research papers
• Topical
Reviews (5000-8000 words)
Contact details for submission
Manuscripts should be submitted
to the journal's online submission and editorial system,
http://ees.elsevier.com/cls.
For questions regarding the submission
process, please look at
http://epsupport.elsevier.com.
For questions regarding
the reviewing process, please contact the Editor-in-Chief: Miles D. Houslay, at
m.houslay@bio.gla.ac.uk, the Editor: Nigel
Pyne, at
n.j.pyne@strath.ac.uk, or one of the Co-Editors: George S. Baillie, at
G.Baillie@biolgla.ac.uk,
or Susan Pyne at
susan.pynes@strath.ac.uk, depending on who is handling your article.
Ethics in publishing
For information on Ethics in publishing and Ethical guidelines
for journal publication see
http://www.elsevier.com/publishingethics and
http://www.elsevier.com/ethicalguidelines.
Policy and ethics
The work described in your article must have been carried out in accordance with
The
Code of Ethics of the World Medical Association (Declaration of Helsinki) for experiments involving humans http://www.wma.net/en/30publications/10policies/b3/index.html;
EU Directive 2010/63/EU for animal experiments http://ec.europa.eu/environment/chemicals/lab_animals/legislation_en.htm;
Uniform Requirements for manuscripts submitted to Biomedical journals http://www.icmje.org. This must be stated
at an appropriate point in the article.
Conflict of interest
All authors are requested to
disclose any actual or potential conflict of interest including any financial, personal or other relationships with other people or organizations
within three years of beginning the submitted work that could inappropriately influence, or be perceived to influence, their work. See
also
http://www.elsevier.com/conflictsofinterest.
Submission declaration
Submission
of an article implies that the work described has not been published previously (except in the form of an abstract or as part of a published
lecture or academic thesis), that it is not under consideration for publication elsewhere, that its publication is approved by all authors
and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published
elsewhere including electronically in the same form, in English or in any other language, without the written consent of the copyright-holder.
Contributors
Each author is required to declare his or her individual contribution to the article: all authors
must have materially participated in the research and/or article preparation, so roles for all authors should be described. The statement
that all authors have approved the final article should be true and included in the disclosure.
Changes
to authorship
This policy concerns the addition, deletion, or rearrangement of author names in the authorship of accepted
manuscripts:
Before the accepted manuscript is published in an online issue: Requests to add or remove an author, or to rearrange
the author names, must be sent to the Journal Manager from the corresponding author of the accepted manuscript and must include: (a)
the reason the name should be added or removed, or the author names rearranged and (b) written confirmation (e-mail, fax, letter) from
all authors that they agree with the addition, removal or rearrangement. In the case of addition or removal of authors, this includes
confirmation from the author being added or removed. Requests that are not sent by the corresponding author will be forwarded by the
Journal Manager to the corresponding author, who must follow the procedure as described above. Note that: (1) Journal Managers will inform
the Journal Editors of any such requests and (2) publication of the accepted manuscript in an online issue is suspended until authorship
has been agreed.
After the accepted manuscript is published in an online issue: Any requests to add, delete, or rearrange
author names in an article published in an online issue will follow the same policies as noted above and result in a corrigendum.
Copyright
Upon acceptance of an article, authors will be asked to complete a 'Journal Publishing Agreement'
(for more information on this and copyright see
http://www.elsevier.com/copyright). Acceptance of the agreement will ensure
the widest possible dissemination of information. An e-mail will be sent to the corresponding author confirming receipt of the manuscript
together with a 'Journal Publishing Agreement' form or a link to the online version of this agreement.
Subscribers may reproduce
tables of contents or prepare lists of articles including abstracts for internal circulation within their institutions. Permission of
the Publisher is required for resale or distribution outside the institution and for all other derivative works, including compilations
and translations (please consult
http://www.elsevier.com/permissions). If excerpts from other copyrighted works are included,
the author(s) must obtain written permission from the copyright owners and credit the source(s) in the article. Elsevier has preprinted
forms for use by authors in these cases: please consult
http://www.elsevier.com/permissions.
Retained
author rights
As an author you (or your employer or institution) retain certain rights; for details you are referred to:
http://www.elsevier.com/authorsrights.
Role of the funding source
You are requested
to identify who provided financial support for the conduct of the research and/or preparation of the article and to briefly describe
the role of the sponsor(s), if any, in study design; in the collection, analysis and interpretation of data; in the writing of the report;
and in the decision to submit the article for publication. If the funding source(s) had no such involvement then this should be stated.
Please see
http://www.elsevier.com/funding.
Funding body agreements and policies
Elsevier
has established agreements and developed policies to allow authors whose articles appear in journals published by Elsevier, to comply
with potential manuscript archiving requirements as specified as conditions of their grant awards. To learn more about existing agreements
and policies please visit
http://www.elsevier.com/fundingbodies.
Open access
This
journal offers you the option of making your article freely available to all via the ScienceDirect platform. To prevent any conflict
of interest, you can only make this choice after receiving notification that your article has been accepted for publication. The fee
of $3,000 excludes taxes and other potential author fees such as color charges. In some cases, institutions and funding bodies have entered
into agreement with Elsevier to meet these fees on behalf of their authors. Details of these agreements are available at
http://www.elsevier.com/fundingbodies.
Authors of accepted articles, who wish to take advantage of this option, should complete and submit the order form (available at
http://www.elsevier.com/locate/openaccessform.pdf).
Whatever access option you choose, you retain many rights as an author, including the right to post a revised personal version of your
article on your own website. More information can be found here:
http://www.elsevier.com/authorsrights.
Language and language services
Please write your text in good English (American or British usage is accepted,
but not a mixture of these). Authors who require information about language editing and copyediting services pre- and post-submission
please visit
http://webshop.elsevier.com/languageservices
or our customer support site at
http://support.elsevier.com
for more information.
Submission
Submission to this journal proceeds totally online and
you will be guided stepwise through the creation and uploading of your files. The system automatically converts source files to a single
PDF file of the article, which is used in the peer-review process. Please note that even though manuscript source files are converted
to PDF files at submission for the review process, these source files are needed for further processing after acceptance. All correspondence,
including notification of the Editor's decision and requests for revision, takes place by e-mail removing the need for a paper trail.
Referees
Please submit, with the manuscript, the names, addresses and e-mail addresses of three potential
referees. Note that the editor retains the sole right to decide whether or not the suggested reviewers are used.
Use of wordprocessing software
It is important that the file be saved in the native format of the wordprocessor
used. The text should be in single-column format. Keep the layout of the text as simple as possible. Most formatting codes will be removed
and replaced on processing the article. In particular, do not use the wordprocessor's options to justify text or to hyphenate words.
However, do use bold face, italics, subscripts, superscripts etc. When preparing tables, if you are using a table grid, use only one
grid for each individual table and not a grid for each row. If no grid is used, use tabs, not spaces, to align columns. The electronic
text should be prepared in a way very similar to that of conventional manuscripts (see also the Guide to Publishing with Elsevier:
http://www.elsevier.com/guidepublication).
Note that source files of figures, tables and text graphics will be required whether or not you embed your figures in the text. See also
the section on Electronic artwork.
To avoid unnecessary errors you are strongly advised to use the 'spell-check' and 'grammar-check'
functions of your wordprocessor.
Article structure
Subdivision - numbered
sections
Divide your article into clearly defined and numbered sections. Subsections should be numbered 1.1 (then 1.1.1,
1.1.2, ...), 1.2, etc. (the abstract is not included in section numbering). Use this numbering also for internal cross-referencing: do
not just refer to 'the text'. Any subsection may be given a brief heading. Each heading should appear on its own separate line.
Introduction
State the objectives of the work and provide an adequate background, avoiding a detailed literature
survey or a summary of the results.
Material and methods
Provide sufficient detail to allow
the work to be reproduced. Methods already published should be indicated by a reference: only relevant modifications should be described.
Results
Results should be clear and concise.
Discussion
This
should explore the significance of the results of the work, not repeat them. A combined Results and Discussion section is often appropriate.
Avoid extensive citations and discussion of published literature.
Conclusions
A short
Conclusions section is to be presented and should be divided into specific points.
Essential title page
information
•
Title.
Concise and informative. Titles are often used in information-retrieval systems.
Avoid abbreviations and formulae where possible.
•
Author names and affiliations.
Where the family name may be
ambiguous (e.g., a double name), please indicate this clearly. Present the authors' affiliation addresses (where the actual work was
done) below the names. Indicate all affiliations with a lower-case superscript letter immediately after the author's name and in front
of the appropriate address. Provide the full postal address of each affiliation, including the country name and, if available, the e-mail
address of each author.
•
Corresponding author.
Clearly indicate who will handle correspondence at all stages
of refereeing and publication, also post-publication.
Ensure that telephone and fax numbers (with country and area code) are provided
in addition to the e-mail address and the complete postal address. Contact details must be kept up to date by the corresponding author.
•
Present/permanent address.
If an author has moved since the work described in the article was done, or was visiting at
the time, a 'Present address' (or 'Permanent address') may be indicated as a footnote to that author's name. The address at which the
author actually did the work must be retained as the main, affiliation address. Superscript Arabic numerals are used for such footnotes.
Abstract
A concise and factual abstract is required. The abstract should state briefly the purpose of the
research, the principal results and major conclusions. An abstract is often presented separately from the article, so it must be able
to stand alone. For this reason, References should be avoided, but if essential, then cite the author(s) and year(s). Also, non-standard
or uncommon abbreviations should be avoided, but if essential they must be defined at their first mention in the abstract itself.
Graphical abstract
A Graphical abstract is optional and should summarize the contents of the article in a
concise, pictorial form designed to capture the attention of a wide readership online. Authors must provide images that clearly represent
the work described in the article. Graphical abstracts should be submitted as a separate file in the online submission system. Image
size: Please provide an image with a minimum of 531 × 1328 pixels (h × w) or proportionally more. The image should be readable
at a size of 5 × 13 cm using a regular screen resolution of 96 dpi. Preferred file types: TIFF, EPS, PDF or MS Office files. See
http://www.elsevier.com/graphicalabstracts for examples.
Authors can make use of Elsevier's Illustration and Enhancement
service to ensure the best presentation of their images also in accordance with all technical requirements:
Illustration Service.
Highlights
Highlights are mandatory for
this journal. They consist of a short collection of bullet points that convey the core findings of the article and should be submitted
in a separate file in the online submission system. Please use 'Highlights' in the file name and include 3 to 5 bullet points (maximum
85 characters, including spaces, per bullet point). See
http://www.elsevier.com/highlights for examples.
Keywords
Immediately after the abstract, provide a maximum of 6 keywords, using British spelling and avoiding
general and plural terms and multiple concepts (avoid, for example, 'and', 'of'). Be sparing with abbreviations: only abbreviations firmly
established in the field may be eligible. These keywords will be used for indexing purposes.
Abbreviations
Define
abbreviations that are not standard in this field in a footnote to be placed on the first page of the article. Such abbreviations that
are unavoidable in the abstract must be defined at their first mention there, as well as in the footnote. Ensure consistency of abbreviations
throughout the article.
Acknowledgements
Collate acknowledgements in a separate section
at the end of the article before the references and do not, therefore, include them on the title page, as a footnote to the title or
otherwise. List here those individuals who provided help during the research (e.g., providing language help, writing assistance or proof
reading the article, etc.).
Database linking
Elsevier aims at connecting online articles
with external databases which are useful in their respective research communities. If your article contains relevant unique identifiers
or accession numbers (bioinformatics) linking to information on entities (genes, proteins, diseases, etc.) or structures deposited in
public databases, then please indicate those entities according to the standard explained below.
Authors should explicitly mention
the
database abbreviation (as mentioned below) together with the actual database number, bearing in mind that an error in a
letter or number can result in a dead link in the online version of the article.
Please use the following format:
Database ID:
xxxx
Links can be provided in your online article to the following databases (examples of citations are given in parentheses):
•
ASTM: ASTM Standards Database (ASTM ID: G63)
•
CCDC:
Cambridge Crystallographic Data Centre (CCDC ID: AI631510)
•
GenBank:
Genetic sequence database at the National Center for Biotechnology Information (NCBI) (GenBank ID: BA123456)
•
GEO:
Gene Expression Omnibus (GEO ID: GSE27196; GEO ID: GPL5366; GEO ID: GSM9853)
•
MI:
EMBL-EBI OLS Molecular Interaction Ontology (MI ID: 0218)
•
MINT:
Molecular INTeractions database (MINT ID: 6166710)
•
NCBI Taxonomy:
NCBI Taxonomy Browser (NCBI Taxonomy ID: 48184)
•
NCT: ClinicalTrials.gov
(NCT ID: NCT00222573)
•
OMIM: Online Mendelian Inheritance
in Man (OMIM ID: 601240)
•
PDB: Worldwide Protein Data
Bank (PDB ID: 1TUP)
•
TAIR: The Arabidopsis Information Resource
database (TAIR ID: AT1G01020)
•
UniProt: Universal Protein Resource
Knowledgebase (UniProt ID: Q9H0H5)
Artwork
Electronic artwork
General
points
• Make sure you use uniform lettering and sizing of your original artwork.
• Save text in illustrations
as 'graphics' or enclose the font.
• Only use the following fonts in your illustrations: Arial, Courier, Times, Symbol.
•
Number the illustrations according to their sequence in the text.
• Use a logical naming convention for your artwork files.
• Provide captions to illustrations separately.
• Produce images near to the desired size of the printed version.
•
Submit each figure as a separate file.
A detailed guide on electronic artwork is available on our website:
http://www.elsevier.com/artworkinstructions
You are urged to visit this site; some excerpts from the detailed information are given here.
Formats
Regardless
of the application used, when your electronic artwork is finalised, please 'save as' or convert the images to one of the following formats
(note the resolution requirements for line drawings, halftones, and line/halftone combinations given below):
EPS: Vector drawings.
Embed the font or save the text as 'graphics'.
TIFF: Color or grayscale photographs (halftones): always use a minimum of 300 dpi.
TIFF: Bitmapped line drawings: use a minimum of 1000 dpi.
TIFF: Combinations bitmapped line/half-tone (color or grayscale): a
minimum of 500 dpi is required.
If your electronic artwork is created in a Microsoft Office application (Word, PowerPoint, Excel)
then please supply 'as is'.
Please do not:
• Supply files that are optimised for screen use (e.g., GIF, BMP, PICT,
WPG); the resolution is too low;
• Supply files that are too low in resolution;
• Submit graphics that are disproportionately
large for the content.
Figure Captions
Ensure that each illustration has a caption.
Supply captions separately, not attached to the figure. A caption should comprise a brief title (
not on the figure itself) and
a description of the illustration. Keep text in the illustrations themselves to a minimum but explain all symbols and abbreviations used.
All colour artwork will appear online free of charge. (The printed issue will contain a black and white / greyscale version). Please
ensure at proofstage that the figure legends of any colour figures refer the reader to the colour version of the figure which will be
made available online only.
Tables
Number tables consecutively in accordance with their
appearance in the text. Place footnotes to tables below the table body and indicate them with superscript lowercase letters. Avoid vertical rules. Be sparing in the use of tables and ensure that the data presented in tables do not duplicate results described elsewhere in the
article.
References
Citation in text
Please ensure that every
reference cited in the text is also present in the reference list (and vice versa). Any references cited in the abstract must be given
in full. Unpublished results and personal communications are not recommended in the reference list, but may be mentioned in the text.
If these references are included in the reference list they should follow the standard reference style of the journal and should include
a substitution of the publication date with either 'Unpublished results' or 'Personal communication'. Citation of a reference as 'in
press' implies that the item has been accepted for publication.
Web references
As a minimum,
the full URL should be given and the date when the reference was last accessed. Any further information, if known (DOI, author names,
dates, reference to a source publication, etc.), should also be given. Web references can be listed separately (e.g., after the reference
list) under a different heading if desired, or can be included in the reference list.
Reference Style
Text:
Indicate references by number(s) in square brackets in line with the text. The actual authors can be referred to, but the reference
number(s) must always be given.
Example: "..... as demonstrated [3,6]. Barnaby and Jones [8] obtained a different result ...."
List:
Number the references (numbers in square brackets) in the list in the order in which they appear in the text.
Examples:
Reference to a journal publication:
[1] J. van der Geer, J.A.J. Hanraads, R.A. Lupton, J. Sci. Commun. 163 (2000) 51-59.
Reference
to a book:
[2] W. Strunk Jr., E.B. White, The Elements of Style, third ed., Macmillan, New York, 1979.
Reference to a chapter
in an edited book:
[3] G.R. Mettam, L.B. Adams, in: B.S. Jones, R.Z. Smith (Eds.), Introduction to the Electronic Age, E-Publishing,
Inc. New York, 1994, pp. 281-304.
Responsibility for the accuracy of bibliographic citations lies entirely with the authors.
Video data
Elsevier accepts video material and animation sequences to support and enhance your scientific
research. Authors who have video or animation files that they wish to submit with their article are strongly encouraged to include these
within the body of the article. This can be done in the same way as a figure or table by referring to the video or animation content
and noting in the body text where it should be placed. All submitted files should be properly labeled so that they directly relate to
the video file's content. In order to ensure that your video or animation material is directly usable, please provide the files in one
of our recommended file formats with a preferred maximum size of 50 MB. Video and animation files supplied will be published online in
the electronic version of your article in Elsevier Web products, including ScienceDirect:
http://www.sciencedirect.com.
Please supply 'stills' with your files: you can choose any frame from the video or animation or make a separate image. These will be
used instead of standard icons and will personalize the link to your video data. For more detailed instructions please visit our video
instruction pages at
http://www.elsevier.com/artworkinstructions. Note: since video and animation cannot be embedded in
the print version of the journal, please provide text for both the electronic and the print version for the portions of the article that
refer to this content.
Supplementary data
Elsevier accepts electronic supplementary material
to support and enhance your scientific research. Supplementary files offer the author additional possibilities to publish supporting
applications, high-resolution images, background datasets, sound clips and more. Supplementary files supplied will be published online
alongside the electronic version of your article in Elsevier Web products, including ScienceDirect:
http://www.sciencedirect.com.
In order to ensure that your submitted material is directly usable, please provide the data in one of our recommended file formats. Authors
should submit the material in electronic format together with the article and supply a concise and descriptive caption for each file.
For more detailed instructions please visit our artwork instruction pages at
http://www.elsevier.com/artworkinstructions.
Submission checklist
The following list will be useful during the final checking of an article prior to sending
it to the journal for review. Please consult this Guide for Authors for further details of any item.
Ensure that the following
items are present:
One author has been designated as the corresponding author with contact details:
• E-mail address
• Full postal address
• Telephone and fax numbers
All necessary files have been uploaded, and contain:
•
Keywords
• All figure captions
• All tables (including title, description, footnotes)
Further considerations
•
Manuscript has been 'spell-checked' and 'grammar-checked'
• References are in the correct format for this journal
•
All references mentioned in the Reference list are cited in the text, and vice versa
• Permission has been obtained for use
of copyrighted material from other sources (including the Web)
• Color figures are clearly marked as being intended for color
reproduction on the Web (free of charge) and in print, or to be reproduced in color on the Web (free of charge) and in black-and-white
in print
• If only color on the Web is required, black-and-white versions of the figures are also supplied for printing purposes
For any further information please visit our customer support site at
http://support.elsevier.com.
Use of the Digital
Object Identifier
The Digital Object Identifier (DOI) may be used to cite and link to electronic documents. The DOI consists
of a unique alpha-numeric character string which is assigned to a document by the publisher upon the initial electronic publication.
The assigned DOI never changes. Therefore, it is an ideal medium for citing a document, particularly 'Articles in press' because they
have not yet received their full bibliographic information. The correct format for citing a DOI is shown as follows (example taken from
a document in the journal
Physics Letters B):
doi:10.1016/j.physletb.2010.09.059
When you use the DOI to create URL
hyperlinks to documents on the web, the DOIs are guaranteed never to change.
Proofs
One
set of page proofs (as PDF files) will be sent by e-mail to the corresponding author (if we do not have an e-mail address then paper
proofs will be sent by post) or, a link will be provided in the e-mail so that authors can download the files themselves. Elsevier now
provides authors with PDF proofs which can be annotated; for this you will need to download Adobe Reader version 7 (or higher) available
free from
http://get.adobe.com/reader. Instructions on how to annotate PDF files will accompany the proofs (also given online).
The exact system requirements are given at the Adobe site:
http://www.adobe.com/products/reader/tech-specs.html.
If
you do not wish to use the PDF annotations function, you may list the corrections (including replies to the Query Form) and return them
to Elsevier in an e-mail. Please list your corrections quoting line number. If, for any reason, this is not possible, then mark the corrections
and any other comments (including replies to the Query Form) on a printout of your proof and return by fax, or scan the pages and e-mail,
or by post. Please use this proof only for checking the typesetting, editing, completeness and correctness of the text, tables and figures.
Significant changes to the article as accepted for publication will only be considered at this stage with permission from the Editor.
We will do everything possible to get your article published quickly and accurately – please let us have all your corrections within
48 hours. It is important to ensure that all corrections are sent back to us in one communication: please check carefully before replying,
as inclusion of any subsequent corrections cannot be guaranteed. Proofreading is solely your responsibility. Note that Elsevier may proceed
with the publication of your article if no response is received.
Offprints
The corresponding
author, at no cost, will be provided with a PDF file of the article via e-mail. For an extra charge, paper offprints can be ordered via
the offprint order form which is sent once the article is accepted for publication. The PDF file is a watermarked version of the published
article and includes a cover sheet with the journal cover image and a disclaimer outlining the terms and conditions of use.
For inquiries relating to the submission of articles (including electronic submission) please
visit this journal's homepage. Contact details for questions arising after acceptance of an article, especially those relating to proofs,
will be provided by the publisher. You can track accepted articles at
http://www.elsevier.com/trackarticle. You can also
check our Author FAQs (
http://www.elsevier.com/authorFAQ) and/or contact Customer Support via
http://support.elsevier.com.
