Cell Molecular Biology; Pathophysiology; Treatment
Official Journal of the International Bone and Mineral Society



BONE provides a peer-reviewed, interdisciplinary forum for monthly publication of original, experimental, and clinical studies, along with review articles on normal and pathological processes occurring in bone and other tissues affecting calcium metabolism. Additionally, well-documented case reports are invited.

Submissions of manuscripts

Manuscripts must be submitted on BONE's submission and review Web site, http://ees.elsevier.com/bone. If you have a preference, please indicate which editor or associate editor you would like to process your manuscript according to their expertise. The Editors, however, reserve the right to select a different editor or associate editor to monitor the review process, as the expertise of the proposed editor or associate editor should closely match the subject matter of the manuscript. Please also suggest five possible reviewers. When recommending reviewers, authors should avoid naming more than one scientist from any one institution or from closely related scientists/institutions. For each reviewer, please provide name of institution, telephone number, and e-mail address.
Submission of an article implies that the work described has not been published previously (except in the form of an abstract or as part of a published lecture or academic thesis), that it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work is carried out, and that, if accepted, it will not be published elsewhere in the same form, in English or in any other language, without the written consent of the copyright holder. Manuscripts are published in English only.

For questions regarding submission, please contact:

Bone editorial office
525 B Street, Suite 1900
San Diego, CA 92101-4495, USA
Telephone: (619) 699-6782
Fax: (619) 699-6211
Email: bone@elsevier.com

English editing. The following individuals or services are members of the (United States) Council of Science Editors or other professional organizations and have expressed interest in helping authors of manuscripts submitted to BONE with English editing. Authors may contact these individuals or services directly by mail, phone, fax, or e-mail. All financial arrangements are strictly between the two parties. BONE neither endorses nor recommends any specific individual or service. Professional editing, while often recommended by reviewers, does not ensure acceptance or publication of a manuscript.

Diana B. Mathis, ELS, 5559 Raleigh Street, Pittsburgh, PA 15217-1534, USA; telephone: 412-521-6346; fax: 412-422-5082; e-mail: dbmathis@fyi.net

Lynda Charters, Medical International, P.O. Box 5966, Marlboro, MA 01752, USA; telephone: 508-788-0726; fax: 508-788-0742; e-mail: medintl@aol.com

MedEdit, USA, 15101 Magnolia Boulevard, E24, Sherman Oaks, CA 91403, USA;telephone: 818-986-1715; fax: 818-986-5507; e-mail: adawson@hsc.usc.edu

Karin Mesches, Ph.D., SciTechEdit International, 7012 East Mountain Brush Circle,Highlands Ranch, CO 80130, USA; fax: 303-773-6660;e-mail: editor@scitechedit.com; Web page: http://www.scitechedit.com

Gary D. Novack, Ph.D., Member, AMWA, PharmaLogic Development, Inc., 17 Bridgegate Drive, San Rafael, CA 94903, USA; telephone: 415-472-2181; fax: 415-472-2183; e-mail: gary_novack@pharmalogic.com; Web page: www.pharmalogic.com

Rhana Pike (Ms), ELS, Sydney, NSW 2001, Australia; telephone: 61-2-9569-7831; e-mail: rhana@australianeditor.com.

Susan Erickson, 130 Winchester Street, Brookline, MA 02446, USA; telephone: 617-731-3415; e-mail: rhanap@ozemail.com.au

Language Polishing: Authors who require information about language editing and copyediting services pre- and post-submission, please visit http://www.elsevier.com/locate/languagepolishing or contact authorsupport@elsevier.com for more information. Please note Elsevier neither endorses nor take responsibility for any products, good or services offered by outside vendors through our services or in any advertising. For more information please refer to our Terms and Conditions http://www.elsevier.com/termsconditions

Only one revision will be permitted. A subsequent revision will be treated as a new submission.

Conflict of interest policy. Authors are required to disclose commercial or similar relationships to products or companies mentioned in or related to the subject matter of the article being submitted. Sources of funding for the article should be acknowledged on the title page. Affiliations of authors should include corporate appointments relating to or in connection with products or companies mentioned in the article, or otherwise bearing on the subject matter thereof. Other pertinent financial relationships, such as consultancies, stock ownership, or other equity interests or patent-licensing arrangements, should be disclosed in the cover letter at the time of submission. Such relationships may be disclosed in the journal at the discretion of the editor-in-chief in footnotes appearing on the title page. Questions about this policy should be directed to the editor-in-chief.

Copyright. Upon acceptance of an article, authors will be asked to sign a “Journal Publishing Agreement” (for more information on this and copyright, see http://www.elsevier.com/copyright). Acceptance of the agreement will ensure the widest possible dissemination of information. An e-mail (or letter) will be sent to the corresponding author confirming receipt of the manuscript with a “Journal Publishing Agreement” form or a link to the online version of this agreement. Subscribers may reproduce tables of contents or prepare lists of articles including abstracts for internal circulation within their institutions. Permission of the Publisher is required for resale or distribution outside the institution and for all other derivative works, including compilations and translations (please consult http://www.elsevier.com/permissions).

If excerpts from other copyrighted works are included, the author(s) must obtain written permission from the copyright owners and credit the source(s) in the article. Elsevier has preprinted forms for use by authors in these cases: please consult http://www.elsevier.com/permissions.

Ethics:

When human subjects are used, manuscripts must be accompanied by a statement that the experiments were undertaken with the understanding and written consent of each subject, with the approval of the appropriate local ethics committee, and in compliance with national legislation and the Code of Ethical Principles for Medical Research Involving Human Subjects of the World Medical Association (Declaration of Helsinki) http://www.wma.net/e/policy/b3.htm].
When experimental animals are used, the materials and methods section must clearly indicate that adequate measures were taken to minimise pain or discomfort, and that the experiments were conducted in accordance with international standards on animal welfare as well as being compliant with local and national regulations. Studies are expected to be compliant with minimal standards as defined by the European Communities Council Directive of 24 November 1986 (86/609/EEC)

US National Institutes of Health (NIH) voluntary posting (" Public Access") policy

Elsevier facilitates author response to the NIH voluntary posting request (referred to as the NIH "Public Access Policy"; see http://www.nih.gov/about/publicaccess/index.htm) by posting the peer-reviewed author's manuscript directly to PubMed Central on request from the author, 12 months after formal publication. Upon notification from Elsevier of acceptance, we will ask you to confirm via e-mail (by e-mailing us at NIHauthorrequest@elsevier.com) that your work has received NIH funding and that you intend to respond to the NIH policy request, along with your NIH award number to facilitate processing. Upon such confirmation, Elsevier will submit to PubMed Central on your behalf a version of your manuscript that will include peer-review comments, for posting 12 months after formal publication. This will ensure that you will have responded fully to the NIH request policy. There will be no need for you to post your manuscript directly with PubMed Central, and any such posting is prohibited.

Expedited review for Rapid Communications provides authors the opportunity to rapidly publish data they consider particularly novel or valuable to the scientific community. If accepted, the paper will be inserted into the next available issue still in press (usually after approximately 3 months), provided that it is a maximum of 4000 words printed pages and does not require extensive revisions. Authors should note that acceptance criteria for this category are significantly more stringent.

Editorials, Reviews, and Minireviews. Although these are most often by invitation, authors who wish to express their opinion or write reviews about scientific matters of interest to the community can submit such manuscripts to BONE. Editorials and minireviews should be 2000-3000 words printed pages and not require extensive revisions to be acceptable for publication.
Sponsored supplements and/or commercial reprints: for more information please contact Elsevier Life Sciences Commercial Sales, Radarweg 29, 1043 NX, Amsterdam, The Netherlands; phone (+31) (20) 4852939/2059; email: LSCS@elsevier.com.

Nomenclature

For chemical nomenclature, follow the Subject Index of Chemical Abstracts, capitalize trade names, and give manufacturers' or suppliers' names and addresses. Give the meaning of an abbreviation the first time it appears. Define a nonstandard abbreviation when it first appears in the text. For detailed text entry instructions, see http://www.elsevier.com/locate/guidepublication

For manuscripts dealing with bone histomorphometry, please use the nomenclature approved by the American Society for Bone and Mineral Research (Parfitt AM, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR. Bone histomorphometry nomenclature, symbols and units: report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Min Res 1987;2:595-610).

For DXA nomenclature and decimal digits. The ISCD Official Position is as follows. DXA Nomenclature u DXA - not DEXA. u T-score - not T score, t-score, or t score u Z-score - not Z score, z-score, or z score DXA Decimal Digits Preferred number of decimal digits for DXA reporting: u BMD: 3 digits (example, 0.927 g/cm2) u T-score: 1 digit (example, -2.3) u Z-score: 1 digit (example, 1.7) u BMC: 2 digits (example, 31.76 g) u Area: 2 digits (example, 43.25 cm2) u % reference database: Integer (example, 82%)

For manuscripts dealing with osteoclast differentiation and osteoclast function, please use the Proposed Standard Nomenclature for New Tumor Necrosis Factor Members Involved in the Regulation of Bone Resorption (Report of the ASBMR President's Committee on Nomenclature. Bone 2000;27:761-4).

For manuscripts dealing with bone markers, please use the Recommendation for Bone Marker Nomenclature and Abbreviations (position paper, Committee of Scientific Advisors, International Osteoporosis Foundation. Bone 2001;28:575-6).

Preparation of manuscripts

Papers should be double spaced with at least 1-inch (2.5 cm) margins. Number all pages consecutively. Type tables, footnotes, and figure legends double spaced on separate pages.

The title page should show the paper's title, authors, and the complete names of institutions where work was done. Please include the name, mailing address, telephone and fax numbers, and e-mail address of the author to whom correspondence and proofs are to be sent.

Each manuscript should include an abstract of not more than 350 words, intelligible to the general reader without reference to the text. List 5 keywords on a separate sheet for use by indexing and abstract services. Manuscript text should follow standard arrangement: Introduction, Materials and methods, Results, and Discussion.

Acknowledgments should be on a separate page at the end of the text.

References should be cited in the text by a number in square brackets and listed at the end of the paper in numerical order. Only articles that have been published or are in press should be included in the references. Unpublished results or personal communications should be cited as such in the text. Include full article titles and abbreviate journal titles according to the List of Journals Indexed in Index Medicus. Format references as shown in the examples below.

[1] Brockstedt H, Kassem M, Ericksen EF, Mosekilde L, Melsen F. Age- and sex-related changes in the iliac cortical bone mass and remodeling. Bone 1993;14:681-91.

[2] Coccia PF. Bone marrow transplantation for osteoporosis. In: Forman SJ, Blume KG, Thomas ED, editors. Bone marrow transplantation. Boston, MA: Blackwell; 1993; 874, 882.

[3] Lacowikz, J. R. Principles of fluorescence. New York: Plenum; 1983, p. 112-53.

Tables. Type each table on a separate page at the end of the manuscript, cite in order in the text, and number consecutively with Arabic numerals. Each table should have a title typed above it. Indicate table footnotes by superscript lowercase letters.

Figures must be self-explanatory, titled, cited in order in the text, and numbered consecutively with Arabic numerals. On separate pages, type figure titles with their (brief) legends. Figures should not be embedded in text. Several figures may be grouped into a plate on one page. Lettering on micrographs should be clearly legible. Letters 2 mm high are recommended. Limit the field of micrographs to structures specifically discussed in the report. Symbols and areas of special interest should not be close to the edges. Give figure magnification in the legends and on the figures (micrometer scale). Symbols (minimum 3 mm height) used on micrographs must be explained in the figure legends. For detailed artwork instructions, see http://www.elsevier.com/artworkinstructions

Color Figures If together with your accepted article, you submit usable color figures, then Elsevier will ensure, at no additional charge, that these figures will appear in color on the Web (e.g., ScienceDirect and other sites) regardless of whether these illustrations are reproduced in color in the printed version. For color reproduction in print, you will receive information regarding the costs from Elsevier after receipt of your accepted article. For further information on the preparation of electronic artwork, please see http://www.elsevier.com/artworkinstructions [Please note: Because of technical complications that can arise in converting color figures to "gray scale" (for the printed version should you not opt for color in print), please submit in addition usable black-and-white files corresponding to all the color illustrations.]

Authors should not that a request to revert from full colour to colour only in the electronic publication at the stage of typesetting and proof correction, will require separate editorial agreement, with possible re-review if necessary, and may significantly delay publication of your manuscript.

Color cover photos. Authors are encouraged to include a color image of any subject in relation to their submitted manuscript for use as cover of the issue in which their manuscript will appear. If the image is also used as illustration within the original manuscript, the costs of the specific plate will be waived.

Supplementary material:

Electronic supplementary material is now accepted to support and enhance your scientific research. Supplementary files offer the author additional possibilities to publish supporting applications, movies, animation sequences, high-resolution images, background datasets, sound clips and more. Supplementary files supplied will be published online alongside the electronic version of your article in Elsevier web products, including ScienceDirect: http://www.sciencedirect.com. In order to ensure that your submitted material is directly usable, please ensure that data is provided in one of our recommended file formats. Authors should submit the material in electronic format together with the article and supply a concise and descriptive caption for each file. For more detailed instructions please visit our Corporate Website at http://www.elsevier.com/authors .

Proofs

Proofs will be sent to the corresponding author. To avoid delay in publication, only necessary changes may be made, and corrections should be returned promptly.

Offprints:

The corresponding author, at no cost, will be provided with a PDF offprint by default, but can choose to receive 50 paper copies instead.

Author enquiries:

For enquiries relating to the submission of articles (including electronic submission where available) please visit this journal's homepage at http://www.elsevier.com/locate/bone. You can track accepted articles at http://www.elsevier.com/trackarticle and set up e-mail alerts to inform you of when an article's status has changed, as well as copyright information, frequently asked questions and more. Contact details for questions arising after acceptance of an article, especially those relating to proofs, are provided after registration of an article for publication.

Disclaimer:

Whilst every effort is made by the publishers and editorial board to see that no inaccurate or misleading data, opinion or statement appears in this journal, they wish to make it clear that the data and opinions appearing in the articles and advertisements herein are the sole responsibility of the contributor or advertiser concerned. Accordingly, the publishers, the editorial board and editors and their respective employees, officers and agents accept no responsibility or liability.