Guide for Authors
The
journal is an international forum devoted to research and developments in the applications of whole-cell and cell-free enzymes as catalysts
in organic synthesis. Emphasis is focused on mechanistic and synthetic aspects of the biocatalytic transformation.
Papers should report
novel and significant advances in one or more of the following topics;
• Applied and fundamental studies of enzymes used
for biocatalysis;
• Industrial applications of enzymatic processes, e.g. in fine chemical synthesis;
• Chemo-, regio-
and enantioselective transformations;
• Screening for biocatalysts;
• Integration of biocatalytic and chemical steps
in organic syntheses;
• Novel biocatalysts, e.g. enzymes from extremophiles and catalytic antibodies;
• Enzyme immobilization
and stabilization, particularly in non-conventional media;
• Bioprocess engineering aspects, e.g. membrane bioreactors;
•
Improvement of catalytic performance of enzymes, e.g. by protein engineering or chemical modification;
• Structural studies,
including computer simulation, relating to substrate specificity and reaction selectivity;
• Biomimetic studies related to enzymatic
transformations.
Types of Paper
The journal publishes three types of papers:
1.
Full-length, or regular papers describing original research work not previously published.
2. Reviews of specialized topics within
the scope of the Journal (prospective authors should obtain preliminary approval from an Editor before preparing such an article); short
reviews on enzymatic processes will be considered.
3. Letters reporting results which should be made rapidly available to other researchers
in the field. They should consist of concise descriptions or brief reports of investigations. They may be completely documented (description
of experimental procedure, reference to literature, etc.). Letters will be considered for publication only if they report on new reactions,
catalysts or mechanisms, and are a maximum of 4 printed pages in length. The authors are requested to indicate, in a covering letter,
the reasons which justify the publication of their results as a Letter.
Ethics in publishing
For information on Ethics in publishing and Ethical guidelines for journal publication
see
http://www.elsevier.com/publishingethics and
http://www.elsevier.com/ethicalguidelines.
Conflict of interest
All authors are requested to disclose any actual or potential conflict of interest including
any financial, personal or other relationships with other people or organizations within three years of beginning the submitted work
that could inappropriately influence, or be perceived to influence, their work. See also
http://www.elsevier.com/conflictsofinterest.
Submission declaration
Submission of an article implies that the work described has not been published previously
(except in the form of an abstract or as part of a published lecture or academic thesis), that it is not under consideration for publication
elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was
carried out, and that, if accepted, it will not be published elsewhere including electronically in the same form, in English or in any
other language, without the written consent of the copyright-holder.
Changes to authorship
This
policy concerns the addition, deletion, or rearrangement of author names in the authorship of accepted manuscripts:
Before the
accepted manuscript is published in an online issue: Requests to add or remove an author, or to rearrange the author names, must
be sent to the Journal Manager from the corresponding author of the accepted manuscript and must include: (a) the reason the name should
be added or removed, or the author names rearranged and (b) written confirmation (e-mail, fax, letter) from all authors that they agree
with the addition, removal or rearrangement. In the case of addition or removal of authors, this includes confirmation from the author
being added or removed. Requests that are not sent by the corresponding author will be forwarded by the Journal Manager to the corresponding
author, who must follow the procedure as described above. Note that: (1) Journal Managers will inform the Journal Editors of any such
requests and (2) publication of the accepted manuscript in an online issue is suspended until authorship has been agreed.
After
the accepted manuscript is published in an online issue: Any requests to add, delete, or rearrange author names in an article published
in an online issue will follow the same policies as noted above and result in a corrigendum.
Copyright
Upon
acceptance of an article, authors will be asked to complete a 'Journal Publishing Agreement' (for more information on this and copyright
see
http://www.elsevier.com/copyright). Acceptance of the agreement will ensure the widest possible dissemination of information.
An e-mail will be sent to the corresponding author confirming receipt of the manuscript together with a 'Journal Publishing Agreement'
form or a link to the online version of this agreement.
Subscribers may reproduce tables of contents or prepare lists of articles
including abstracts for internal circulation within their institutions. Permission of the Publisher is required for resale or distribution
outside the institution and for all other derivative works, including compilations and translations (please consult
http://www.elsevier.com/permissions).
If excerpts from other copyrighted works are included, the author(s) must obtain written permission from the copyright owners and credit
the source(s) in the article. Elsevier has preprinted forms for use by authors in these cases: please consult
http://www.elsevier.com/permissions.
Retained author rights
As an author you (or your employer or institution) retain certain rights; for details
you are referred to:
http://www.elsevier.com/authorsrights.
Role of the funding source
You
are requested to identify who provided financial support for the conduct of the research and/or preparation of the article and to briefly
describe the role of the sponsor(s), if any, in study design; in the collection, analysis and interpretation of data; in the writing
of the report; and in the decision to submit the article for publication. If the funding source(s) had no such involvement then this
should be stated. Please see
http://www.elsevier.com/funding.
Funding body agreements and
policies
Elsevier has established agreements and developed policies to allow authors whose articles appear in journals
published by Elsevier, to comply with potential manuscript archiving requirements as specified as conditions of their grant awards. To
learn more about existing agreements and policies please visit
http://www.elsevier.com/fundingbodies.
Open access
This journal offers you the option of making your article freely available to all via the ScienceDirect
platform. To prevent any conflict of interest, you can only make this choice after receiving notification that your article has been
accepted for publication. The fee of $3,000 excludes taxes and other potential author fees such as color charges. In some cases, institutions
and funding bodies have entered into agreement with Elsevier to meet these fees on behalf of their authors. Details of these agreements
are available at
http://www.elsevier.com/fundingbodies. Authors of accepted articles, who wish to take advantage of this
option, should complete and submit the order form (available at
http://www.elsevier.com/locate/openaccessform.pdf). Whatever
access option you choose, you retain many rights as an author, including the right to post a revised personal version of your article
on your own website. More information can be found here:
http://www.elsevier.com/authorsrights.
Language
and language services
Please write your text in good English (American or British usage is accepted, but not a mixture
of these). Authors who require information about language editing and copyediting services pre- and post-submission please visit
http://webshop.elsevier.com/languageservices or our customer support
site at
http://support.elsevier.com
for more information.
Submission
Submission to this journal proceeds totally online.
Use the following guidelines to prepare your article. Via the homepage of this journal (
http://ees.elsevier.com/molcab/)
you will be guided stepwise through the creation and uploading of the various files. The system automatically converts source files to
a single Adobe Acrobat PDF version of the article, which is used in the peer-review process. Please note that even though manuscript
source files are converted to PDF at submission for the review process, these source files are needed for further processing after acceptance.
All correspondence, including notification of the Editor's decision and requests for revision, takes place by e-mail and via the author's
homepage, removing the need for a hard-copy paper trail.
Referees
Please submit, with the
manuscript, the names, addresses and e-mail addresses of three potential referees. Note that the editor retains the sole right to decide
whether or not the suggested reviewers are used.
Use of wordprocessing
software
It is important that the file be saved in the native format of the wordprocessor used. The text should be in single-column
format. Keep the layout of the text as simple as possible. Most formatting codes will be removed and replaced on processing the article.
In particular, do not use the wordprocessor's options to justify text or to hyphenate words. However, do use bold face, italics, subscripts,
superscripts etc. When preparing tables, if you are using a table grid, use only one grid for each individual table and not a grid for
each row. If no grid is used, use tabs, not spaces, to align columns. The electronic text should be prepared in a way very similar to
that of conventional manuscripts (see also the Guide to Publishing with Elsevier:
http://www.elsevier.com/guidepublication).
Note that source files of figures, tables and text graphics will be required whether or not you embed your figures in the text. See also
the section on Electronic artwork.
To avoid unnecessary errors you are strongly advised to use the 'spell-check' and 'grammar-check'
functions of your wordprocessor.
Article structure
Subdivision - numbered
sections
Divide your article into clearly defined and numbered sections. Subsections should be numbered 1.1 (then 1.1.1,
1.1.2, ...), 1.2, etc. (the abstract is not included in section numbering). Use this numbering also for internal cross-referencing: do
not just refer to 'the text'. Any subsection may be given a brief heading. Each heading should appear on its own separate line.
Introduction
State the objectives of the work and provide an adequate background, avoiding a detailed literature
survey or a summary of the results.
Experimental
Provide sufficient detail to allow
the work to be reproduced. Methods already published should be indicated by a reference: only relevant modifications should be described.
Results
Results should be clear and concise.
Discussion
This
should explore the significance of the results of the work, not repeat them. A combined Results and Discussion section is often appropriate.
Avoid extensive citations and discussion of published literature.
Conclusions
A short
conclusions section is to be presented.
Appendices
If there is more than one appendix, they
should be identified as A, B, etc. Formulae and equations in appendices should be given separate numbering: Eq. (A.1), Eq. (A.2), etc.;
in a subsequent appendix, Eq. (B.1) and so on. Similarly for tables and figures: Table A.1; Fig. A.1, etc.
Essential
title page information
•
Title.
Concise and informative. Titles are often used in information-retrieval
systems. Avoid abbreviations and formulae where possible.
•
Author names and affiliations.
Where the family name
may be ambiguous (e.g., a double name), please indicate this clearly. Present the authors' affiliation addresses (where the actual work
was done) below the names. Indicate all affiliations with a lower-case superscript letter immediately after the author's name and in
front of the appropriate address. Provide the full postal address of each affiliation, including the country name and, if available,
the e-mail address of each author.
•
Corresponding author.
Clearly indicate who will handle correspondence at
all stages of refereeing and publication, also post-publication.
Ensure that telephone and fax numbers (with country and area code)
are provided in addition to the e-mail address and the complete postal address. Contact details must be kept up to date by the corresponding
author.
•
Present/permanent address.
If an author has moved since the work described in the article was done,
or was visiting at the time, a 'Present address' (or 'Permanent address') may be indicated as a footnote to that author's name. The address
at which the author actually did the work must be retained as the main, affiliation address. Superscript Arabic numerals are used for
such footnotes.
Abstract
A concise and factual abstract is required. The abstract should
state briefly the purpose of the research, the principal results and major conclusions. An abstract is often presented separately from
the article, so it must be able to stand alone. For this reason, References should be avoided, but if essential, then cite the author(s)
and year(s). Also, non-standard or uncommon abbreviations should be avoided, but if essential they must be defined at their first mention
in the abstract itself.
Graphical abstract
A Graphical abstract is mandatory for this journal.
It should summarize the contents of the article in a concise, pictorial form designed to capture the attention of a wide readership online.
Authors must provide images that clearly represent the work described in the article. Graphical abstracts should be submitted as a separate
file in the online submission system. Image size: please provide an image with a minimum of 531 × 1328 pixels (h × w) or
proportionally more. The image should be readable at a size of 5 × 13 cm using a regular screen resolution of 96 dpi. Preferred
file types: TIFF, EPS, PDF or MS Office files. See
http://www.elsevier.com/graphicalabstracts for examples.
Authors
can make use of Elsevier's Illustration and Enhancement service to ensure the best presentation of their images also in accordance with
all technical requirements:
Illustration
Service.
Highlights
Highlights are mandatory for this journal. They consist
of a short collection of bullet points that convey the core findings of the article and should be submitted in a separate file in the
online submission system. Please use 'Highlights' in the file name and include 3 to 5 bullet points (maximum 85 characters, including
spaces, per bullet point). See
http://www.elsevier.com/highlights for examples.
Keywords
Immediately after the abstract, provide a maximum of 5 keywords, using American spelling and avoiding general and plural terms and multiple
concepts (avoid, for example, "and", "of"). Be sparing with abbreviations: only abbreviations firmly established in the field may be
eligible. These keywords will be used for indexing purposes.
Abbreviations
Define abbreviations
that are not standard in this field in a footnote to be placed on the first page of the article. Such abbreviations that are unavoidable
in the abstract must be defined at their first mention there, as well as in the footnote. Ensure consistency of abbreviations throughout
the article.
Acknowledgements
Collate acknowledgements in a separate section at the end
of the article before the references and do not, therefore, include them on the title page, as a footnote to the title or otherwise.
List here those individuals who provided help during the research (e.g., providing language help, writing assistance or proof reading
the article, etc.).
Nomenclature and Units
Follow internationally accepted rules and
conventions: use the international system of units (SI). If other quantities are mentioned, give their equivalent in SI. You are urged
to consult the International Union of Pure and Applied Chemistry (IUPAC)
http://www.iupac.org/ for further information.
Footnotes
Footnotes should be used sparingly. Number them consecutively throughout the article, using
superscript Arabic numbers. Many wordprocessors build footnotes into the text, and this feature may be used. Should this not be the case,
indicate the position of footnotes in the text and present the footnotes themselves separately at the end of the article. Do not include
footnotes in the Reference list.
Table footnotes
Indicate each footnote in a table with a superscript lowercase letter.
Artwork
Electronic artwork
General points
• Make sure you
use uniform lettering and sizing of your original artwork.
• Save text in illustrations as 'graphics' or enclose the font.
•
Only use the following fonts in your illustrations: Arial, Courier, Times, Symbol.
• Number the illustrations according to their
sequence in the text.
• Use a logical naming convention for your artwork files.
• Provide captions to illustrations
separately.
• Produce images near to the desired size of the printed version.
• Submit each figure as a separate file.
A detailed guide on electronic artwork is available on our website:
http://www.elsevier.com/artworkinstructions
You
are urged to visit this site; some excerpts from the detailed information are given here.
Formats
Regardless of
the application used, when your electronic artwork is finalised, please 'save as' or convert the images to one of the following formats
(note the resolution requirements for line drawings, halftones, and line/halftone combinations given below):
EPS: Vector drawings.
Embed the font or save the text as 'graphics'.
TIFF: Color or grayscale photographs (halftones): always use a minimum of 300 dpi.
TIFF: Bitmapped line drawings: use a minimum of 1000 dpi.
TIFF: Combinations bitmapped line/half-tone (color or grayscale): a
minimum of 500 dpi is required.
If your electronic artwork is created in a Microsoft Office application (Word, PowerPoint, Excel)
then please supply 'as is'.
Please do not:
• Supply files that are optimised for screen use (e.g., GIF, BMP, PICT,
WPG); the resolution is too low;
• Supply files that are too low in resolution;
• Submit graphics that are disproportionately
large for the content.
Color artwork
Please make sure that artwork files are in an acceptable
format (TIFF, EPS or MS Office files) and with the correct resolution. If, together with your accepted article, you submit usable color
figures then Elsevier will ensure, at no additional charge, that these figures will appear in color on the Web (e.g., ScienceDirect and
other sites) regardless of whether or not these illustrations are reproduced in color in the printed version.
For color reproduction
in print, you will receive information regarding the costs from Elsevier after receipt of your accepted article. Please indicate
your preference for color: in print or on the Web only. For further information on the preparation of electronic artwork, please see
http://www.elsevier.com/artworkinstructions.
Please note: Because of technical complications which can arise by converting
color figures to 'gray scale' (for the printed version should you not opt for color in print) please submit in addition usable black
and white versions of all the color illustrations.
Figure captions
Ensure that each illustration
has a caption. Supply captions separately, not attached to the figure. A caption should comprise a brief title (
not on the figure
itself) and a description of the illustration. Keep text in the illustrations themselves to a minimum but explain all symbols and abbreviations
used.
Tables
Number tables consecutively in accordance with their appearance in the text.
Place footnotes to tables below the table body and indicate them with superscript lowercase letters. Avoid vertical rules. Be sparing
in the use of tables and ensure that the data presented in tables do not duplicate results described elsewhere in the article.
References
Citation in text
Please ensure that every reference cited in the
text is also present in the reference list (and vice versa). Any references cited in the abstract must be given in full. Unpublished
results and personal communications are not recommended in the reference list, but may be mentioned in the text. If these references
are included in the reference list they should follow the standard reference style of the journal and should include a substitution of
the publication date with either 'Unpublished results' or 'Personal communication'. Citation of a reference as 'in press' implies that
the item has been accepted for publication.
Web references
As a minimum, the full URL should
be given and the date when the reference was last accessed. Any further information, if known (DOI, author names, dates, reference to
a source publication, etc.), should also be given. Web references can be listed separately (e.g., after the reference list) under a different
heading if desired, or can be included in the reference list.
Reference management software
This
journal has standard templates available in key reference management packages EndNote (
http://www.endnote.com/support/enstyles.asp)
and Reference Manager (
http://refman.com/support/rmstyles.asp). Using plug-ins to wordprocessing packages, authors only
need to select the appropriate journal template when preparing their article and the list of references and citations to these will be
formatted according to the journal style which is described below.
Reference style
Text:
Indicate references by number(s) in square brackets in line with the text. The actual authors can be referred to, but the reference number(s)
must always be given.
Example: '..... as demonstrated [3,6]. Barnaby and Jones [8] obtained a different result ....'
List:
Number the references (numbers in square brackets) in the list in the order in which they appear in the text.
Examples:
Reference to a journal publication:
[1] J. van der Geer, J.A.J. Hanraads, R.A. Lupton, J. Sci. Commun. 163 (2010) 51–59.
Reference to a book:
[2] W. Strunk Jr., E.B. White, The Elements of Style, fourth ed., Longman, New York, 2000.
Reference
to a chapter in an edited book:
[3] G.R. Mettam, L.B. Adams, in: B.S. Jones, R.Z. Smith (Eds.), Introduction to the Electronic Age,
E-Publishing, Inc. New York, 2009, pp. 281–304.
Journal abbreviations source
Journal
names should be abbreviated according to
Index Medicus journal abbreviations:
http://www.nlm.nih.gov/tsd/serials/lji.html;
List of title word abbreviations:
http://www.issn.org/2-22661-LTWA-online.php;
CAS (Chemical Abstracts Service):
http://www.cas.org/sent.html.
Video data
Elsevier accepts video material and
animation sequences to support and enhance your scientific research. Authors who have video or animation files that they wish to submit
with their article are strongly encouraged to include these within the body of the article. This can be done in the same way as a figure
or table by referring to the video or animation content and noting in the body text where it should be placed. All submitted files should
be properly labeled so that they directly relate to the video file's content. In order to ensure that your video or animation material
is directly usable, please provide the files in one of our recommended file formats with a preferred maximum size of 50 MB. Video and
animation files supplied will be published online in the electronic version of your article in Elsevier Web products, including ScienceDirect:
http://www.sciencedirect.com. Please supply 'stills' with your files: you can choose any frame from the video or animation
or make a separate image. These will be used instead of standard icons and will personalize the link to your video data. For more detailed
instructions please visit our video instruction pages at
http://www.elsevier.com/artworkinstructions. Note: since video
and animation cannot be embedded in the print version of the journal, please provide text for both the electronic and the print version
for the portions of the article that refer to this content.
Supplementary data
Elsevier
accepts electronic supplementary material to support and enhance your scientific research. Supplementary files offer the author additional
possibilities to publish supporting applications, high-resolution images, background datasets, sound clips and more. Supplementary files
supplied will be published online alongside the electronic version of your article in Elsevier Web products, including ScienceDirect:
http://www.sciencedirect.com. In order to ensure that your submitted material is directly usable, please provide the data
in one of our recommended file formats. Authors should submit the material in electronic format together with the article and supply
a concise and descriptive caption for each file. For more detailed instructions please visit our artwork instruction pages at
http://www.elsevier.com/artworkinstructions.
Submission checklist
The following list will be useful during the final checking of an article prior to sending
it to the journal for review. Please consult this Guide for Authors for further details of any item.
Ensure that the following
items are present:
One author has been designated as the corresponding author with contact details:
• E-mail address
• Full postal address
• Telephone and fax numbers
All necessary files have been uploaded, and contain:
•
Keywords
• All figure captions
• All tables (including title, description, footnotes)
Further considerations
•
Manuscript has been 'spell-checked' and 'grammar-checked'
• References are in the correct format for this journal
•
All references mentioned in the Reference list are cited in the text, and vice versa
• Permission has been obtained for use
of copyrighted material from other sources (including the Web)
• Color figures are clearly marked as being intended for color
reproduction on the Web (free of charge) and in print, or to be reproduced in color on the Web (free of charge) and in black-and-white
in print
• If only color on the Web is required, black-and-white versions of the figures are also supplied for printing purposes
For any further information please visit our customer support site at
http://support.elsevier.com.
Use of the Digital
Object Identifier
The Digital Object Identifier (DOI) may be used to cite and link to electronic documents. The DOI consists
of a unique alpha-numeric character string which is assigned to a document by the publisher upon the initial electronic publication.
The assigned DOI never changes. Therefore, it is an ideal medium for citing a document, particularly 'Articles in press' because they
have not yet received their full bibliographic information. The correct format for citing a DOI is shown as follows (example taken from
a document in the journal
Physics Letters B):
doi:10.1016/j.physletb.2010.09.059
When you use the DOI to create URL
hyperlinks to documents on the web, the DOIs are guaranteed never to change.
Proofs
One
set of page proofs (as PDF files) will be sent by e-mail to the corresponding author (if we do not have an e-mail address then paper
proofs will be sent by post) or, a link will be provided in the e-mail so that authors can download the files themselves. Elsevier now
provides authors with PDF proofs which can be annotated; for this you will need to download Adobe Reader version 7 (or higher) available
free from
http://get.adobe.com/reader. Instructions on how to annotate PDF files will accompany the proofs (also given online).
The exact system requirements are given at the Adobe site:
http://www.adobe.com/products/reader/tech-specs.html.
If
you do not wish to use the PDF annotations function, you may list the corrections (including replies to the Query Form) and return them
to Elsevier in an e-mail. Please list your corrections quoting line number. If, for any reason, this is not possible, then mark the corrections
and any other comments (including replies to the Query Form) on a printout of your proof and return by fax, or scan the pages and e-mail,
or by post. Please use this proof only for checking the typesetting, editing, completeness and correctness of the text, tables and figures.
Significant changes to the article as accepted for publication will only be considered at this stage with permission from the Editor.
We will do everything possible to get your article published quickly and accurately – please let us have all your corrections within
48 hours. It is important to ensure that all corrections are sent back to us in one communication: please check carefully before replying,
as inclusion of any subsequent corrections cannot be guaranteed. Proofreading is solely your responsibility. Note that Elsevier may proceed
with the publication of your article if no response is received.
Offprints
The corresponding
author, at no cost, will be provided with a PDF file of the article via e-mail. For an extra charge, paper offprints can be ordered via
the offprint order form which is sent once the article is accepted for publication. The PDF file is a watermarked version of the published
article and includes a cover sheet with the journal cover image and a disclaimer outlining the terms and conditions of use.
For inquiries relating to the submission of articles (including electronic submission) please
visit this journal's homepage. Contact details for questions arising after acceptance of an article, especially those relating to proofs,
will be provided by the publisher. You can track accepted articles at
http://www.elsevier.com/trackarticle. You can also
check our Author FAQs (
http://www.elsevier.com/authorFAQ) and/or contact Customer Support via
http://support.elsevier.com.
