Guide for Authors
A section of Mutation Research - only available as part of a subscription to Mutation Research/Full Set
NOW PUBLISHED
Special issue on
Nutrigenomics
Edited by L.R. Ferguson, A.N. Shelling, D. Lauren, J.A. Heyes, W.C. McNabb
INTRODUCTION
Molecular and Fundamental Mechanisms broadly encompasses all aspects of research that address the detection
of mutations, the mechanisms by which mutations in genes and chromosomes arise, and the modulation of mutagenesis by mutation avoidance
pathways such as DNA repair, cell cycle control and apoptosis. It includes the role of genetic variation in the genesis and manifestation
of mutations, ranging from the variable manner in which xenobiotics are metabolized to variations in the capacity of cells to replicate
and repair damaged DNA. It also includes the contributions of these mechanisms, when perturbed, to animal disease models and to human
disease, with particular emphasis on carcinogenic mechanisms. Chromosome stability is paramount for maintaining cellular homeostasis.
Therefore, the Journal will publish articles on the genesis of aneuploidy and isodisomy, including the roles played by cell cycle checkpoints,
spindle microtubules, centrosomes and kinetocore proteins, and agents that might disrupt them. Since isodisomy can occur as a consequence
of recombination, all aspects of homologous recombination and non-homologous end joining are appropriate. Submission of appropriate epidemiological
studies as well as consequences, including methods for high throughput SNP detection, DNA microarrays and proteomic approaches, are welcome.
The broader scope of the journal is a reflection of the rapid advances in the field of mutation research and the recognition that cellular
responses to DNA damage, including cell cycle checkpoint arrest and apoptosis, cannot be dissociated from the immediate mechanisms by
which DNA is damaged and repaired.
Types of Paper
Mutation Research - Fundamental
and Molecular Mechanisms of Mutagenesis publishes the following types of article: (I) Research papers - papers reporting results of original,
fundamental research. (II) Short communications of up to 5 printed pages. (III)Rapids - are accelerated publications - research papers
identified by the Editor as being of significant quality and thereby qualifying for rapid reviewing, and publication within 8-10 weeks
of acceptance. (IV) Current issues are generally short, 1-2 page comments on a topical theme, and are published within 10 weeks of acceptance.
(V) Volunteered and invited Mini-reviews of less than 10 printed pages, using references generally no later than 2 years old.
Please
note that Full-length reviews comprehensively covering and critically analysing a topic are published in Mutation Research Reviews. Also
published in the Reviews section are invited papers in the series Reflections in Mutation Research, in which research and techniques
that have played an important part in the development of the field of mutation research are revisited and their significance discussed.
Special issues, comprising multiple original and/or review articles written from a particular viewpoint, on a central theme, are published
on a regular basis in the appropriate section of Mutation Research by topic or article type.
Page charges
This journal has no page charges.
Ethics in Publishing
For information on Ethics in Publishing and Ethical
guidelines for journal publication see
http://www.elsevier.com/publishingethics and
http://www.elsevier.com/ethicalguidelines.
Conflict of Interest
All authors are requested to disclose any actual or potential conflict of interest
including any financial, personal or other relationships with other people or organizations within three years of beginning the submitted
work that could inappropriately influence, or be perceived to influence, their work. See also
http://www.elsevier.com/conflictsofinterest.
Mutation
Research - Fundamental and Molecular Mechanisms of Mutagenesis requires full disclosure of all potential conflicts of interest.
At the end of the manuscript text (and in the cover letter of the manuscript), under a subheading "Conflict of Interest statement", all
authors must disclose any financial and personal relationships with other people or organisations that could inappropriately influence
(bias) their work. If there are no conflicts of interest, the authors should state, "The authors declare that there are no conflicts
of interest." Signed copies of the Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis Conflict of Interest policy
form are required upon submission. The Conflict of Interest policy form can be downloaded here. In order to minimize delays, we strongly
advise that the signed copies of these statements are prepared before you submit your manuscript. The corresponding author is responsible
for sharing this document with all co-authors. Each and every co-author must sign an individual disclosure form. The corresponding author
is responsible for uploading their form and those of their co-authors.
Submission declaration
Submission of an article implies that the work described has not been published previously (except in the form of an abstract
or as part of a published lecture or academic thesis), that it is not under consideration for publication elsewhere, that its publication
is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted,
it will not be published elsewhere in the same form, in English or in any other language, without the written consent of the copyright-holder.
Copyright
Upon acceptance of an article, authors will be asked to complete a 'Journal Publishing Agreement'
(for more information on this and copyright see
http://www.elsevier.com/copyright). Acceptance of the agreement will ensure
the widest possible dissemination of information. An e-mail will be sent to the corresponding author confirming receipt of the manuscript
together with a 'Journal Publishing Agreement' form or a link to the online version of this agreement.
Subscribers may reproduce
tables of contents or prepare lists of articles including abstracts for internal circulation within their institutions. Permission of
the Publisher is required for resale or distribution outside the institution and for all other derivative works, including compilations
and translations (please consult
http://www.elsevier.com/permissions). If excerpts from other copyrighted works are included,
the author(s) must obtain written permission from the copyright owners and credit the source(s) in the article. Elsevier has preprinted
forms for use by authors in these cases: please consult
http://www.elsevier.com/permissions.
Retained author rights
As an author you (or your employer or institution) retain certain rights; for details
you are referred to:
http://www.elsevier.com/authorsrights.
Role of the
funding source
You are requested to identify who provided financial support for the conduct of the research and/or preparation
of the article and to briefly describe the role of the sponsor(s), if any, in study design; in the collection, analysis and interpretation
of data; in the writing of the report; and in the decision to submit the paper for publication. If the funding source(s) had no such
involvement then this should be stated. Please see
http://www.elsevier.com/funding.
Funding body agreements and policies
Elsevier has established agreements and developed policies to allow authors whose
articles appear in journals published by Elsevier, to comply with potential manuscript archiving requirements as specified as conditions
of their grant awards. To learn more about existing agreements and policies please visit
http://www.elsevier.com/fundingbodies.
US
National Institutes of Health (NIH) voluntary posting ("Public Access") policy.
Special Subject Repositories
Certain repositories
such as PubMed Central ( PMC ) are authorized under special arrangement with Elsevier to process and post certain articles such as those
funded by the National Institutes of Health under its Public Access policy (see
elsevier.com
for more detail on our policy).
Articles accepted for publication in an Elsevier journal from authors who have indicated that the underlying
research reported in their articles was supported by an NIH grant will be sent by Elsevier to PMC for public access posting 12 months
after final publication. The version of the article provided by Elsevier will include peer-review comments incorporated by the author
into the article. Because the NIH Public Access policy is voluntary, authors may elect not to deposit such articles in PMC. If you wish
to opt out and not deposit to PMC, you may indicate this by sending an e-mail to:
NIHauthorrequest@elsevier.com
Language and language services
Please write your text in good English (American or British usage is accepted,
but not a mixture of these). Authors who require information about language editing and copyediting services pre- and post-submission
please visit
http://www.elsevier.com/languagepolishing or our customer support site at
http://epsupport.elsevier.com
for more information. Please note Elsevier neither endorses nor takes responsibility for any products, goods or services offered by outside
vendors through our services or in any advertising. For more information please refer to our Terms & Conditions:
http://www.elsevier.com/termsandconditions.
Submission
Submission to this journal proceeds totally online and you will be guided stepwise through
the creation and uploading of your files. The system automatically converts source files to a single PDF file of the article, which is
used in the peer-review process. Please note that even though manuscript source files are converted to PDF files at submission for the
review process, these source files are needed for further processing after acceptance. All correspondence, including notification of
the Editor's decision and requests for revision, takes place by e-mail removing the need for a paper trail.
Referees
Please submit, with the manuscript, the names and addresses of 4 potential referees.
Use of wordprocessing software
It
is important that the file be saved in the native format of the wordprocessor used. The text should be in single-column format. Keep
the layout of the text as simple as possible. Most formatting codes will be removed and replaced on processing the article. In particular,
do not use the wordprocessor's options to justify text or to hyphenate words. However, do use bold face, italics, subscripts, superscripts
etc. Do not embed "graphically designed" equations or tables, but prepare these using the wordprocessor's facility. When preparing tables,
if you are using a table grid, use only one grid for each individual table and not a grid for each row. If no grid is used, use tabs,
not spaces, to align columns. The electronic text should be prepared in a way very similar to that of conventional manuscripts (see also
the Guide to Publishing with Elsevier:
http://www.elsevier.com/guidepublication). Do not import the figures into the text
file but, instead, indicate their approximate locations directly in the electronic text and on the manuscript. See also the section on
Electronic illustrations.
To avoid unnecessary errors you are strongly advised to use the "spell-check" and "grammar-check" functions
of your wordprocessor.
Article structure
Subdivision - numbered sections
Divide your article into clearly defined and numbered sections. Subsections should
be numbered 1.1 (then 1.1.1, 1.1.2, ...), 1.2, etc. (the abstract is not included in section numbering). Use this numbering also for
internal cross-referencing: do not just refer to "the text". Any subsection may be given a brief heading. Each heading should appear
on its own separate line.
Introduction
State the objectives of the
work and provide an adequate background, avoiding a detailed literature survey or a summary of the results.
Material and methods
Provide sufficient detail to allow the work to be reproduced. Methods already
published should be indicated by a reference: only relevant modifications should be described.
Results
Results should be clear and concise.
Discussion
This should explore the significance of the results of the work, not repeat them. A combined Results and Discussion section is often
appropriate. Avoid extensive citations and discussion of published literature.
Conclusions
The main conclusions of the study may be presented in a short Conclusions section, which may stand alone or form a subsection of
a Discussion or Results and Discussion section.
Appendices
If there
is more than one appendix, they should be identified as A, B, etc. Formulae and equations in appendices should be given separate numbering:
Eq. (A.1), Eq. (A.2), etc.; in a subsequent appendix, Eq. (B.1) and so on.
Essential
title page information
•
Title.
Concise and informative. Titles are often used in information-retrieval
systems. Avoid abbreviations and formulae where possible.
•
Author names and affiliations.
Where the family name
may be ambiguous (e.g., a double name), please indicate this clearly. Present the authors' affiliation addresses (where the actual work
was done) below the names. Indicate all affiliations with a lower-case superscript letter immediately after the author's name and in
front of the appropriate address. Provide the full postal address of each affiliation, including the country name, and, if available,
the e-mail address of each author.
•
Corresponding author.
Clearly indicate who will handle correspondence at
all stages of refereeing and publication, also post-publication.
Ensure that telephone and fax numbers (with country and area code)
are provided in addition to the e-mail address and the complete postal address.
•
Present/permanent address.
If an author has moved since the work described in the article was done, or was visiting at the time, a "Present address" (or "Permanent
address") may be indicated as a footnote to that author's name. The address at which the author actually did the work must be retained
as the main, affiliation address. Superscript Arabic numerals are used for such footnotes.
Abstract
A concise and factual abstract is required. The abstract should state briefly the purpose of the research, the
principal results and major conclusions. An abstract is often presented separately from the article, so it must be able to stand alone.
For this reason, References should be avoided, but if essential, then cite the author(s) and year(s). Also, non-standard or uncommon
abbreviations should be avoided, but if essential they must be defined at their first mention in the abstract itself. Your abstract should
not exceed
300 words.
Keywords
Immediately after the abstract,
provide 3-6 keywords or short phrases, using American spelling and avoiding general and plural terms and multiple concepts (avoid, for
example, "and", "of"). Be sparing with abbreviations: only abbreviations firmly established in the field may be eligible. These keywords
will be used for indexing purposes.
Abbreviations
Define abbreviations
that are not standard in this field in a footnote to be placed on the first page of the article. Such abbreviations that are unavoidable
in the abstract must be defined at their first mention there, as well as in the footnote. Ensure consistency of abbreviations throughout
the article.
Acknowledgements
Collate acknowledgements in a separate section
at the end of the article before the references and do not, therefore, include them on the title page, as a footnote to the title or
otherwise. List here those individuals who provided help during the research (e.g., providing language help, writing assistance or proof
reading the article, etc.).
Accession Numbers
Accession numbers are unique
identifiers in bioinformatics allocated to nucleotide and protein sequences to allow tracking of different versions of that sequence
record and the associated sequence in a data repository [e.g., databases at the National Center for Biotechnical Information (NCBI) at
the National Library of Medicine ('GenBank') and the Worldwide Protein Data Bank]. There are different types of accession numbers in
use based on the type of sequence cited, each of which uses a different coding. Authors should explicitly mention the
type of accession
number together with the actual number, bearing in mind that an error in a letter or number can result in a dead link in the online
version of the article. Please use the following format: accession number type ID: xxxx (e.g., MMDB ID: 12345; PDB ID: 1TUP). Note that
in the final version of the
electronic copy, accession numbers will be linked to the appropriate database, enabling readers
to go directly to that source from the article.
Minimum Information About a Microarray Experiment - MIAME
Nucleic acid and
protein sequences (sequences that have not been previously published), macromolecular structures determined by X-ray crystallography
(along with structure factors), and microarray data must be deposited in the appropriate public database (
http://www.cell.com/misc/page?page=misc5)
and must be accessible without restriction from the date of publication. An entry name or accession number must be included as the last
paragraph of the Experimental Procedures section in the final version of the manuscript. Microarray data should be MIAME compliant (for
guidelines see
http://www.mged.org/Workgroups/MIAME/miame.html).
Gene accession numbers
In the electronic version
of a published manuscript, gene accession numbers will be linked directly to the gene's description in NCBI's Nucleotide sequence database.
The accession number should be formatted as follows:
Accession no. AJ315850 and in the text e.g. ". . . at the amino acid sequence
level to the human IDN3 gene (Accession No. AJ315850)."
The production department will then link this reference when they find it in
the text. Authors should DOUBLE-CHECK the number they use to make absolutely sure that it is correct before referring to it in their
paper. Accession numbers in proofs should also always be checked for correctness. The number is an essential part of the link.
Artwork
Electronic artwork
General points
• Make sure you use uniform lettering and sizing of your original artwork.
• Save text in illustrations as "graphics"
or enclose the font.
• Only use the following fonts in your illustrations: Arial, Courier, Times, Symbol.
• Number
the illustrations according to their sequence in the text.
• Use a logical naming convention for your artwork files.
•
Provide captions to illustrations separately.
• Produce images near to the desired size of the printed version.
• Submit
each figure as a separate file.
A detailed guide on electronic artwork is available on our website:
http://www.elsevier.com/artworkinstructions
You are urged to visit this site; some excerpts from the detailed information are given here.
Formats
Regardless
of the application used, when your electronic artwork is finalised, please "save as" or convert the images to one of the following formats
(note the resolution requirements for line drawings, halftones, and line/halftone combinations given below):
EPS: Vector drawings.
Embed the font or save the text as "graphics".
TIFF: color or grayscale photographs (halftones): always use a minimum of 300 dpi.
TIFF: Bitmapped line drawings: use a minimum of 1000 dpi.
TIFF: Combinations bitmapped line/half-tone (color or grayscale): a
minimum of 500 dpi is required.
DOC, XLS or PPT: If your electronic artwork is created in any of these Microsoft Office applications
please supply "as is".
Please do not:
• Supply embedded graphics in your wordprocessor (spreadsheet, presentation)
document;
• Supply files that are optimised for screen use (like GIF, BMP, PICT, WPG); the resolution is too low;
•
Supply files that are too low in resolution;
• Submit graphics that are disproportionately large for the content.
Color artwork
Please make sure that artwork files are in an acceptable format (TIFF, EPS or MS Office
files) and with the correct resolution. If, together with your accepted article, you submit usable color figures then Elsevier will ensure,
at no additional charge, that these figures will appear in color on the Web (e.g., ScienceDirect and other sites) regardless of whether
or not these illustrations are reproduced in color in the printed version.
For color reproduction in print, you will receive information
regarding the costs from Elsevier after receipt of your accepted article. Please indicate your preference for color in print or on
the Web only. For further information on the preparation of electronic artwork, please see
http://www.elsevier.com/artworkinstructions.
Please note: Because of technical complications which can arise by converting color figures to "gray scale" (for the printed version
should you not opt for color in print) please submit in addition usable black and white versions of all the color illustrations.
Figure captions
Ensure that each illustration has a caption. Supply captions separately, not attached
to the figure. A caption should comprise a brief title (
not on the figure itself) and a description of the illustration. Keep
text in the illustrations themselves to a minimum but explain all symbols and abbreviations used.
Tables
Number tables consecutively in accordance with their appearance in the text. Place footnotes to tables below the
table body and indicate them with superscript lowercase letters. Avoid vertical rules. Be sparing in the use of tables and ensure that
the data presented in tables do not duplicate results described elsewhere in the article.
References
Citation in text
Please ensure that every reference
cited in the text is also present in the reference list (and vice versa). Any references cited in the abstract must be given in full.
Unpublished results and personal communications are not recommended in the reference list, but may be mentioned in the text. If these
references are included in the reference list they should follow the standard reference style of the journal and should include a substitution
of the publication date with either "Unpublished results" or "Personal communication" Citation of a reference as "in press" implies that
the item has been accepted for publication.
Web references
As a minimum,
the full URL should be given. Any further information, if known (DOI, author names, dates, reference to a source publication, etc.),
should also be given. Web references can be listed separately (e.g., after the reference list) under a different heading if desired,
or can be included in the reference list.
References in a special issue
Please ensure that the words 'this issue' are added to any references in the list (and any citations in the text) to other articles
in the same Special Issue.
Reference style
Text: Indicate
references by number(s) in square brackets in line with the text. The actual authors can be referred to, but the reference number(s)
must always be given.
Example: "..... as demonstrated [3,6]. Barnaby and Jones [8] obtained a different result ...."
List:
Number the references (numbers in square brackets) in the list in the order in which they appear in the text.
Examples:
Reference to a journal publication:
[1] J. van der Geer, J.A.J. Hanraads, R.A. Lupton, The art of writing a scientific article,
J. Sci. Commun. 163 (2000) 51-59.
Reference to a book:
[2] W. Strunk Jr., E.B. White, The Elements of Style, third ed., Macmillan,
New York, 1979.
Reference to a chapter in an edited book:
[3] G.R. Mettam, L.B. Adams, How to prepare an electronic version of
your article, in: B.S. Jones, R.Z. Smith (Eds.), Introduction to the Electronic Age, E-Publishing Inc., New York, 1999, pp. 281-304.
Supplementary material
Elsevier accepts electronic supplementary material to support and enhance your scientific
research. Supplementary files offer the author additional possibilities to publish supporting applications, movies, animation sequences,
high-resolution images, background datasets, sound clips and more. Supplementary files supplied will be published online alongside the
electronic version of your article in Elsevier Web products, including ScienceDirect:
http://www.sciencedirect.com. In order
to ensure that your submitted material is directly usable, please ensure that data are provided in one of our recommended file formats.
Authors should submit the material in electronic format together with the article and supply a concise and descriptive caption for each
file. Video files: please supply 'stills' with your files: you can choose any frame from the video or make a separate image. These will
be used instead of standard icons and will personalize the link to your supplementary information. For more detailed instructions please
visit our artwork instruction pages at
http://www.elsevier.com/artworkinstructions.
Submission checklist
It is hoped that this list will be useful during the final checking of an article prior to sending
it to the journal's Editor for review. Please consult this Guide for Authors for further details of any item.
Ensure that the
following items are present:
One Author designated as corresponding Author:
• E-mail address
• Full postal
address
• Telephone and fax numbers
All necessary files have been uploaded
• Keywords
• All figure captions
• All tables (including title, description, footnotes)
Further considerations
• Manuscript has been "spellchecked"
and "grammar-checked"
• References are in the correct format for this journal
• All references mentioned in the Reference
list are cited in the text, and vice versa
• Permission has been obtained for use of copyrighted material from other sources
(including the Web)
• Color figures are clearly marked as being intended for color reproduction on the Web (free of charge)
and in print or to be reproduced in color on the Web (free of charge) and in black-and-white in print
• If only color on the
Web is required, black and white versions of the figures are also supplied for printing purposes
For any further information please
visit our customer support site at
http://epsupport.elsevier.com.
Use of the Digital Object Identifier
The Digital Object Identifier (DOI)
may be used to cite and link to electronic documents. The DOI consists of a unique alpha-numeric character string which is assigned to
a document by the publisher upon the initial electronic publication. The assigned DOI never changes. Therefore, it is an ideal medium
for citing a document, particularly 'Articles in press' because they have not yet received their full bibliographic information. The
correct format for citing a DOI is shown as follows (example taken from a document in the journal
Physics Letters B):
doi:10.1016/j.physletb.2003.10.071
When you use the DOI to create URL hyperlinks to documents on the web, they are guaranteed never to change.
Proofs
One set of page proofs (as PDF files) will be sent by e-mail to the corresponding author (if we do
not have an e-mail address then paper proofs will be sent by post) or, a link will be provided in the e-mail so that authors can download
the files themselves. Elsevier now provides authors with PDF proofs which can be annotated; for this you will need to download Adobe
Reader version 7 (or higher) available free from
http://www.adobe.com/products/acrobat/readstep2.html. Instructions on how
to annotate PDF files will accompany the proofs (also given online). The exact system requirements are given at the Adobe site:
http://www.adobe.com/products/acrobat/acrrsystemreqs.html#70win.
If you do not wish to use the PDF annotations function, you may list the corrections (including replies to the Query Form) and
return them to Elsevier in an e-mail. Please list your corrections quoting line number. If, for any reason, this is not possible, then
mark the corrections and any other comments (including replies to the Query Form) on a printout of your proof and return by fax, or scan
the pages and e-mail, or by post. Please use this proof only for checking the typesetting, editing, completeness and correctness of the
text, tables and figures. Significant changes to the article as accepted for publication will only be considered at this stage with permission
from the Editor. We will do everything possible to get your article published quickly and accurately. Therefore, it is important to ensure
that all of your corrections are sent back to us in one communication: please check carefully before replying, as inclusion of any subsequent
corrections cannot be guaranteed. Proofreading is solely your responsibility. Note that Elsevier may proceed with the publication of
your article if no response is received.
Offprints
The corresponding author,
at no cost, will be provided with a PDF file of the article via e-mail. The PDF file is a watermarked version of the published article
and includes a cover sheet with the journal cover image and a disclaimer outlining the terms and conditions of use. Additional paper
offprints can be ordered by the authors. An order form with prices will be sent to the corresponding author.
For inquiries relating to the submission of articles (including electronic submission
where available) please visit this journal's homepage. You can track accepted articles at
http://www.elsevier.com/trackarticle
and set up e-mail alerts to inform you of when an article's status has changed. Also accessible from here is information on copyright,
frequently asked questions and more. Contact details for questions arising after acceptance of an article, especially those relating
to proofs, will be provided by the publisher.
Home | Elsevier Sites | Privacy Policy | Terms and Conditions | Feedback | Site Map | A Reed Elsevier Company