Guide for Authors
SCOPE OF THE JOURNAL
The
journal publishes papers innovative, original research involving the controlled release and delivery of drugs and other biologically
active agents. The terms "controlled release" and "delivery" are used in their broadest sense to include mechanisms
such as diffusion, chemical and enzymatic reactions, dissolution, osmosis, targeting, as well as the utilization and manipulation of
biological processes. A broad spectrum of studies dealing with all aspects of controlled release and delivery, including gene delivery,
tissue engineering and diagnostic agents, is encouraged. The use of prodrugs and carriers such as water-soluble polymers, micro and nanoparticles,
liposomes and micelles is included in the scope.
Papers that provide no new concepts or mechanistic insights will not be considered.
The Letter of Submission should explain in one paragraph the originality and significance of the submitted work. The manuscript will
not be processed without this information.
It is recommended that all articles do not exceed a total of 14 single-spaced, font size
12, typewritten pages, including references, tables, figure legends and figures. Review articles are allowed up to 28 pages. Please note
that figures and tables should be embedded in the text as close as possible to where they are initially cited.
FOR REVISED PAPERS
ONLY: It is mandatory to upload separate graphic and table files as these will be required if your manuscript is accepted for publication.
Contact details for submission
Persons considering submitting a 'Review' article are encouraged
to send an outline and a CV to the Review Editor.
Review Editor
Prof. V.P. Torchilin, School of Pharmacy, Bouve
College of Health Sciences, Northeastern University, Mugar Building, Room 312, 360 Huntington Ave, Boston, MA 02115, USA; e-mail:
v.torchilin@neu.edu
Ethics in publishing
For information on Ethics in publishing
and Ethical guidelines for journal publication see
http://www.elsevier.com/publishingethics and
http://www.elsevier.com/ethicalguidelines.
Conflict of interest
All authors are requested to disclose any actual or potential conflict of interest including
any financial, personal or other relationships with other people or organizations within three years of beginning the submitted work
that could inappropriately influence, or be perceived to influence, their work. See also
http://www.elsevier.com/conflictsofinterest.
Submission declaration and verification
Submission of an article implies that the work described has not been
published previously (except in the form of an abstract or as part of a published lecture or academic thesis), that it is not under consideration
for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where
the work was carried out, and that, if accepted, it will not be published elsewhere in the same form, in English or in any other language,
including electronically without the written consent of the copyright-holder. To verify originality, your article may be checked by the
originality detection software iThenticate. See also
http://www.elsevier.com/editors/plagdetect.
Changes
to authorship
This policy concerns the addition, deletion, or rearrangement of author names in the authorship of accepted
manuscripts:
Before the accepted manuscript is published in an online issue: Requests to add or remove an author, or to rearrange
the author names, must be sent to the Journal Manager from the corresponding author of the accepted manuscript and must include: (a)
the reason the name should be added or removed, or the author names rearranged and (b) written confirmation (e-mail, fax, letter) from
all authors that they agree with the addition, removal or rearrangement. In the case of addition or removal of authors, this includes
confirmation from the author being added or removed. Requests that are not sent by the corresponding author will be forwarded by the
Journal Manager to the corresponding author, who must follow the procedure as described above. Note that: (1) Journal Managers will inform
the Journal Editors of any such requests and (2) publication of the accepted manuscript in an online issue is suspended until authorship
has been agreed.
After the accepted manuscript is published in an online issue: Any requests to add, delete, or rearrange
author names in an article published in an online issue will follow the same policies as noted above and result in a corrigendum.
Copyright
Upon acceptance of an article, authors will be asked to complete a 'Journal Publishing Agreement'
(for more information on this and copyright see
http://www.elsevier.com/copyright). Acceptance of the agreement will ensure
the widest possible dissemination of information. An e-mail will be sent to the corresponding author confirming receipt of the manuscript
together with a 'Journal Publishing Agreement' form or a link to the online version of this agreement.
Subscribers may reproduce
tables of contents or prepare lists of articles including abstracts for internal circulation within their institutions. Permission of
the Publisher is required for resale or distribution outside the institution and for all other derivative works, including compilations
and translations (please consult
http://www.elsevier.com/permissions). If excerpts from other copyrighted works are included,
the author(s) must obtain written permission from the copyright owners and credit the source(s) in the article. Elsevier has preprinted
forms for use by authors in these cases: please consult
http://www.elsevier.com/permissions.
Retained
author rights
As an author you (or your employer or institution) retain certain rights; for details you are referred to:
http://www.elsevier.com/authorsrights.
Role of the funding source
You are requested
to identify who provided financial support for the conduct of the research and/or preparation of the article and to briefly describe
the role of the sponsor(s), if any, in study design; in the collection, analysis and interpretation of data; in the writing of the report;
and in the decision to submit the article for publication. If the funding source(s) had no such involvement then this should be stated.
Please see
http://www.elsevier.com/funding.
Funding body agreements and policies
Elsevier has established agreements and developed policies to allow authors whose articles appear in journals published by Elsevier, to comply
with potential manuscript archiving requirements as specified as conditions of their grant awards. To learn more about existing agreements
and policies please visit
http://www.elsevier.com/fundingbodies.
Open access
This
journal offers you the option of making your article freely available to all via the ScienceDirect platform. To prevent any conflict
of interest, you can only make this choice after receiving notification that your article has been accepted for publication. The fee
of $3,000 excludes taxes and other potential author fees such as color charges. In some cases, institutions and funding bodies have entered
into agreement with Elsevier to meet these fees on behalf of their authors. Details of these agreements are available at
http://www.elsevier.com/fundingbodies.
Authors of accepted articles, who wish to take advantage of this option, should complete and submit the order form (available at
http://www.elsevier.com/locate/openaccessform.pdf).
Whatever access option you choose, you retain many rights as an author, including the right to post a revised personal version of your
article on your own website. More information can be found here:
http://www.elsevier.com/authorsrights.
Language and language services
Please write your text in good English (American or British usage is accepted,
but not a mixture of these). Authors who require information about language editing and copyediting services pre- and post-submission
please visit
http://webshop.elsevier.com/languageservices
or our customer support site at
http://support.elsevier.com
for more information.
Submission
Submission to this journal proceeds totally online and
you will be guided stepwise through the creation and uploading of your files. The system automatically converts source files to a single
PDF file of the article, which is used in the peer-review process. Please note that even though manuscript source files are converted
to PDF files at submission for the review process, these source files are needed for further processing after acceptance. All correspondence,
including notification of the Editor's decision and requests for revision, takes place by e-mail removing the need for a paper trail.
Additional information
The authors should ensure that they have written entirely original works, and if the
authors have used the work and/or words of others, this has been appropriately cited or quoted. An author should not in general publish
manuscripts describing essentially the same research in more than one journal of primary publication. Plagiarism in all its forms as
well as submission of the same manuscript to more than one journal concurrently constitutes unethical publishing behaviour and are unacceptable.
Thus, the Letter of Submission should explain in one paragraph the originality and significance of the submitted work. The manuscript
will not be processed without this information.
Use of wordprocessing
software
It is important that the file be saved in the native format of the wordprocessor used. The text should be in single-column
format. Keep the layout of the text as simple as possible. Most formatting codes will be removed and replaced on processing the article.
In particular, do not use the wordprocessor's options to justify text or to hyphenate words. However, do use bold face, italics, subscripts,
superscripts etc. When preparing tables, if you are using a table grid, use only one grid for each individual table and not a grid for
each row. If no grid is used, use tabs, not spaces, to align columns. The electronic text should be prepared in a way very similar to
that of conventional manuscripts (see also the Guide to Publishing with Elsevier:
http://www.elsevier.com/guidepublication).
See also the section on Electronic illustrations.
To avoid unnecessary errors you are strongly advised to use the "spell-check" and
"grammar-check" functions of your wordprocessor.
Article structure
Introduction
State
the objectives of the work and provide an adequate background, avoiding a detailed literature survey or a summary of the results.
Material and methods
Provide sufficient detail to allow the work to be reproduced. Methods already published
should be indicated by a reference: only relevant modifications should be described.
Results
Results
should be clear and concise.
Discussion
This should explore the significance of the results
of the work, not repeat them. A combined Results and Discussion section is often appropriate. Avoid extensive citations and discussion
of published literature.
Conclusions
The main conclusions of the study may be presented
in a short Conclusions section, which may stand alone or form a subsection of a Discussion or Results and Discussion section.
Essential title page information
•
Title.
Concise and informative. Titles are often used
in information-retrieval systems. Avoid abbreviations and formulae where possible.
•
Author names and affiliations.
Where the family name may be ambiguous (e.g., a double name), please indicate this clearly. Present the authors' affiliation addresses
(where the actual work was done) below the names. Indicate all affiliations with a lower-case superscript letter immediately after the
author's name and in front of the appropriate address. Provide the full postal address of each affiliation, including the country name
and, if available, the e-mail address of each author.
•
Corresponding author.
Clearly indicate who will handle
correspondence at all stages of refereeing and publication, also post-publication.
Ensure that telephone and fax numbers (with country
and area code) are provided in addition to the e-mail address and the complete postal address. Contact details must be kept up to date
by the corresponding author.
•
Present/permanent address.
If an author has moved since the work described
in the article was done, or was visiting at the time, a 'Present address' (or 'Permanent address') may be indicated as a footnote to
that author's name. The address at which the author actually did the work must be retained as the main, affiliation address. Superscript
Arabic numerals are used for such footnotes.
Abstract
A concise and factual abstract is
required. The abstract should state briefly the purpose of the research, the principal results and major conclusions. An abstract is
often presented separately from the article, so it must be able to stand alone. For this reason, References should be avoided, but if
essential, then cite the author(s) and year(s). Also, non-standard or uncommon abbreviations should be avoided, but if essential they
must be defined at their first mention in the abstract itself.
Graphical abstract
Authors
must supply a graphical abstract at the time the paper is submitted. The abstract should summarize the contents of the paper in a concise,
pictorial form designed to capture the attention of a wide readership and for compilation of databases. The graphical abstract is posted
online only. Carefully drawn figures that serve to illustrate the theme of the paper are desired. Authors may also provide appropriate
text, not exceeding 30 words. The content of the graphical abstract will be typeset and should be kept within an area of 5 cm by 17 cm
(189 x 642 pixels), images should have a minimum resolution of 300 dpi and line art should be between 1000dpi and 1200dpi. Authors must
supply the graphic separately as an electronic file. For examples of graphical abstracts, please visit the home page of
Journal of
Controlled Release at
http://www.sciencedirect.com/science/journal/01683659.
Keywords
Immediately
after the abstract, provide a maximum of 6 keywords, using American spelling and avoiding general and plural terms and multiple concepts
(avoid, for example, 'and', 'of'). Be sparing with abbreviations: only abbreviations firmly established in the field may be eligible.
These keywords will be used for indexing purposes.
Abbreviations
Abbreviations that are
unavoidable must be defined at their first use in the manuscript. Ensure consistency of abbreviations throughout the article.
Acknowledgements
Collate acknowledgements in a separate section at the end of the article before the references
and do not, therefore, include them on the title page, as a footnote to the title or otherwise. List here those individuals who provided
help during the research (e.g., providing language help, writing assistance or proof reading the article, etc.).
Database
linking
Elsevier aims at connecting online articles with external databases which are useful in their respective research
communities. If your article contains relevant unique identifiers or accession numbers (bioinformatics) linking to information on entities
(genes, proteins, diseases, etc.) or structures deposited in public databases, then please indicate those entities according to the standard
explained below.
Authors should explicitly mention the
database abbreviation (as mentioned below) together with the actual database
number, bearing in mind that an error in a letter or number can result in a dead link in the online version of the article.
Please
use the following format:
Database ID: xxxx
Links can be provided in your online article to the following databases (examples
of citations are given in parentheses):
•
ASTM: ASTM Standards Database
(ASTM ID: G63)
•
CCDC: Cambridge Crystallographic Data Centre
(CCDC ID: AI631510)
•
GenBank: Genetic sequence database
at the National Center for Biotechnology Information (NCBI) (GenBank ID: BA123456)
•
GEO:
Gene Expression Omnibus (GEO ID: GSE27196; GEO ID: GPL5366; GEO ID: GSM9853)
•
MI:
EMBL-EBI OLS Molecular Interaction Ontology (MI ID: 0218)
•
MINT:
Molecular INTeractions database (MINT ID: 6166710)
•
NCBI Taxonomy:
NCBI Taxonomy Browser (NCBI Taxonomy ID: 48184)
•
NCT: ClinicalTrials.gov
(NCT ID: NCT00222573)
•
OMIM: Online Mendelian Inheritance
in Man (OMIM ID: 601240)
•
PDB: Worldwide Protein Data
Bank (PDB ID: 1TUP)
•
TAIR: The Arabidopsis Information Resource
database (TAIR ID: AT1G01020)
•
UniProt: Universal Protein Resource
Knowledgebase (UniProt ID: Q9H0H5)
Artwork
Electronic artwork
General
points
• Make sure you use uniform lettering and sizing of your original artwork.
• Save text in illustrations
as "graphics" or enclose the font.
• Only use the following fonts in your illustrations: Arial, Courier, Times, Symbol.
•
Number the illustrations according to their sequence in the text.
• Use a logical naming convention for your artwork files.
• Provide captions to illustrations separately.
• Produce images near to the desired size of the printed version.
•
Submit each figure as a separate file.
A detailed guide on electronic artwork is available on our website:
http://www.elsevier.com/artworkinstructions
You are urged to visit this site; some excerpts from the detailed information are given here.
Formats
Regardless
of the application used, when your electronic artwork is finalised, please "save as" or convert the images to one of the following formats
(note the resolution requirements for line drawings, halftones, and line/halftone combinations given below):
EPS: Vector drawings.
Embed the font or save the text as "graphics".
TIFF: color or grayscale photographs (halftones): always use a minimum of 300 dpi.
TIFF: Bitmapped line drawings: use a minimum of 1000 dpi.
TIFF: Combinations bitmapped line/half-tone (color or grayscale): a
minimum of 500 dpi is required.
DOC, XLS or PPT: If your electronic artwork is created in any of these Microsoft Office applications
please supply "as is".
Please do not:
• Supply files that are optimised for screen use (like GIF, BMP, PICT, WPG);
the resolution is too low;
• Supply files that are too low in resolution;
• Submit graphics that are disproportionately
large for the content.
Color artwork
Please make sure that artwork files are in an acceptable
format (TIFF, EPS or MS Office files) and with the correct resolution. If, together with your accepted article, you submit usable color
figures then Elsevier will ensure, at no additional charge, that these figures will appear in color on the Web (e.g., ScienceDirect and
other sites) regardless of whether or not these illustrations are reproduced in color in the printed version.
For color reproduction
in print, you will receive information regarding the costs from Elsevier after receipt of your accepted article. Please indicate
your preference for color: in print or on the Web only. For further information on the preparation of electronic artwork, please see
http://www.elsevier.com/artworkinstructions.
Please note: Because of technical complications which can arise by converting
color figures to 'gray scale' (for the printed version should you not opt for color in print) please submit in addition usable black
and white versions of all the color illustrations.
Figure captions
Ensure that each illustration
has a caption. Supply captions separately, not attached to the figure. A caption should comprise a brief title (
not on the figure
itself) and a description of the illustration. Keep text in the illustrations themselves to a minimum but explain all symbols and abbreviations
used.
Tables
Number tables consecutively in accordance with their appearance in the text.
Place footnotes to tables below the table body and indicate them with superscript lowercase letters. Avoid vertical rules. Be sparing
in the use of tables and ensure that the data presented in tables do not duplicate results described elsewhere in the article.
References
Citation in text
Please ensure that every reference cited in the
text is also present in the reference list (and vice versa). Any references cited in the abstract must be given in full. Unpublished
results and personal communications are not recommended in the reference list, but may be mentioned in the text. If these references
are included in the reference list they should follow the standard reference style of the journal and should include a substitution of
the publication date with either 'Unpublished results' or 'Personal communication'. Citation of a reference as 'in press' implies that
the item has been accepted for publication.
Web references
As a minimum, the full URL should
be given and the date when the reference was last accessed. Any further information, if known (DOI, author names, dates, reference to
a source publication, etc.), should also be given. Web references can be listed separately (e.g., after the reference list) under a different
heading if desired, or can be included in the reference list.
References in a special issue
Please
ensure that the words 'this issue' are added to any references in the list (and any citations in the text) to other articles in the same
Special Issue.
Reference management software
This journal has standard templates available
in key reference management packages EndNote (
http://www.endnote.com/support/enstyles.asp) and Reference Manager (
http://refman.com/support/rmstyles.asp).
Using plug-ins to wordprocessing packages, authors only need to select the appropriate journal template when preparing their article
and the list of references and citations to these will be formatted according to the journal style which is described below.
Reference style
Text: Indicate references by number(s) in square brackets in line with the text.
The actual authors can be referred to, but the reference number(s) must always be given.
Example: '..... as demonstrated [3,6]. Barnaby
and Jones [8] obtained a different result ....'
List: Number the references (numbers in square brackets) in the list in
the order in which they appear in the text.
Examples:
Reference to a journal publication:
[1] J. van der Geer, J.A.J.
Hanraads, R.A. Lupton, The art of writing a scientific article, J. Sci. Commun. 163 (2010) 51–59.
Reference to a book:
[2]
W. Strunk Jr., E.B. White, The Elements of Style, fourth ed., Longman, New York, 2000.
Reference to a chapter in an edited book:
[3] G.R. Mettam, L.B. Adams, How to prepare an electronic version of your article, in: B.S. Jones, R.Z. Smith (Eds.), Introduction
to the Electronic Age, E-Publishing Inc., New York, 2009, pp. 281–304.
Journal abbreviations source
Journal
names should be abbreviated according to
Index Medicus journal abbreviations:
http://www.nlm.nih.gov/tsd/serials/lji.html;
List of title word abbreviations:
http://www.issn.org/2-22661-LTWA-online.php;
CAS (Chemical Abstracts Service):
http://www.cas.org/sent.html.
Video data
Elsevier accepts video material and
animation sequences to support and enhance your scientific research. Authors who have video or animation files that they wish to submit
with their article are strongly encouraged to include these within the body of the article. This can be done in the same way as a figure
or table by referring to the video or animation content and noting in the body text where it should be placed. All submitted files should
be properly labeled so that they directly relate to the video file's content. In order to ensure that your video or animation material
is directly usable, please provide the files in one of our recommended file formats with a preferred maximum size of 50 MB. Video and
animation files supplied will be published online in the electronic version of your article in Elsevier Web products, including ScienceDirect:
http://www.sciencedirect.com. Please supply 'stills' with your files: you can choose any frame from the video or animation
or make a separate image. These will be used instead of standard icons and will personalize the link to your video data. For more detailed
instructions please visit our video instruction pages at
http://www.elsevier.com/artworkinstructions. Note: since video
and animation cannot be embedded in the print version of the journal, please provide text for both the electronic and the print version
for the portions of the article that refer to this content.
Supplementary data
Elsevier
accepts electronic supplementary material to support and enhance your scientific research. Supplementary files offer the author additional
possibilities to publish supporting applications, high-resolution images, background datasets, sound clips and more. Supplementary files
supplied will be published online alongside the electronic version of your article in Elsevier Web products, including ScienceDirect:
http://www.sciencedirect.com. In order to ensure that your submitted material is directly usable, please provide the data
in one of our recommended file formats. Authors should submit the material in electronic format together with the article and supply
a concise and descriptive caption for each file. For more detailed instructions please visit our artwork instruction pages at
http://www.elsevier.com/artworkinstructions.
Submission checklist
The following list will be useful during the final checking of an article prior to sending
it to the journal for review. Please consult this Guide for Authors for further details of any item.
Ensure that the following
items are present:
One author has been designated as the corresponding author with contact details:
• E-mail address
• Full postal address
• Telephone and fax numbers
All necessary files have been uploaded, and contain:
•
Keywords
• All figure captions
• All tables (including title, description, footnotes)
Further considerations
•
Manuscript has been 'spell-checked' and 'grammar-checked'
• References are in the correct format for this journal
•
All references mentioned in the Reference list are cited in the text, and vice versa
• Permission has been obtained for use
of copyrighted material from other sources (including the Web)
• Color figures are clearly marked as being intended for color
reproduction on the Web (free of charge) and in print, or to be reproduced in color on the Web (free of charge) and in black-and-white
in print
• If only color on the Web is required, black-and-white versions of the figures are also supplied for printing purposes
For any further information please visit our customer support site at
http://support.elsevier.com.
Additional information
Sources of commercial products
need not be listed unless unique. Published methods need not be restated but must be referenced. Where the reference is to papers under
review or in press, copies should be provided to the Editor to facilitate review. Full chemical names of drugs/polymers/exipients, etc.
should be given. Trade names should not be used. Appropriate statistical analysis of data should be provided
The
Declaration of Helsinki as amended in Seoul 2008 for humans, and the European Community guidelines as accepted principles
for the use of experimental animals, must be adhered to. Therefore, the Journal of Controlled Release will only consider manuscripts
that describe experiments that have been carried out under approval of an institutional or local ethics committee. Authors must state
in the manuscript that the protocol complies with the particular recommendation and that approval of their protocols was obtained.
Full chemical names of drugs/polymers/exipients, etc. should be given. Trade names should not be used. Appropriate statistical analysis
of data should be provided.
Use of the Digital Object
Identifier
The Digital Object Identifier (DOI) may be used to cite and link to electronic documents. The DOI consists of
a unique alpha-numeric character string which is assigned to a document by the publisher upon the initial electronic publication. The
assigned DOI never changes. Therefore, it is an ideal medium for citing a document, particularly 'Articles in press' because they have
not yet received their full bibliographic information. The correct format for citing a DOI is shown as follows (example taken from a
document in the journal
Physics Letters B):
doi:10.1016/j.physletb.2010.09.059
When you use the DOI to create URL hyperlinks
to documents on the web, the DOIs are guaranteed never to change.
Proofs
One set of page
proofs (as PDF files) will be sent by e-mail to the corresponding author (if we do not have an e-mail address then paper proofs will
be sent by post) or, a link will be provided in the e-mail so that authors can download the files themselves. Elsevier now provides authors
with PDF proofs which can be annotated; for this you will need to download Adobe Reader version 7 (or higher) available free from
http://get.adobe.com/reader.
Instructions on how to annotate PDF files will accompany the proofs (also given online). The exact system requirements are given at the
Adobe site:
http://www.adobe.com/products/reader/tech-specs.html.
If you do not wish to use the PDF annotations function,
you may list the corrections (including replies to the Query Form) and return them to Elsevier in an e-mail. Please list your corrections
quoting line number. If, for any reason, this is not possible, then mark the corrections and any other comments (including replies to
the Query Form) on a printout of your proof and return by fax, or scan the pages and e-mail, or by post. Please use this proof only for
checking the typesetting, editing, completeness and correctness of the text, tables and figures. Significant changes to the article as
accepted for publication will only be considered at this stage with permission from the Editor. We will do everything possible to get
your article published quickly and accurately – please let us have all your corrections within 48 hours. It is important to ensure
that all corrections are sent back to us in one communication: please check carefully before replying, as inclusion of any subsequent
corrections cannot be guaranteed. Proofreading is solely your responsibility. Note that Elsevier may proceed with the publication of
your article if no response is received.
Offprints
The corresponding author, at no cost,
will be provided with a PDF file of the article via e-mail. For an extra charge, paper offprints can be ordered via the offprint order
form which is sent once the article is accepted for publication. The PDF file is a watermarked version of the published article and includes
a cover sheet with the journal cover image and a disclaimer outlining the terms and conditions of use.
For inquiries relating to the submission of articles (including electronic submission) please visit this journal's
homepage. Contact details for questions arising after acceptance of an article, especially those relating to proofs, will be provided
by the publisher. You can track accepted articles at
http://www.elsevier.com/trackarticle. You can also check our Author
FAQs (
http://www.elsevier.com/authorFAQ) and/or contact Customer Support via
http://support.elsevier.com.
