General Information: Food and Chemical Toxicology publishes papers that fulfil the views as laid down in the Aims and
Scope section. The Journal's main purpose is the publication of papers reporting and interpreting original unpublished toxicological
research, particularly studies promoting an understanding of the mechanisms underlying toxic effects or improvements in methods for predicting
adverse effects. Papers reporting the toxicological examination of specific foods, chemicals or consumer products will be published,
irrespective of the positive or negative nature of the results, provided the tests and reporting meet current standards of acceptability.
In addition, Brief Communications (see description below) will also be considered, as will concise interpretative Reviews of toxicological
topics of contemporary significance. Letters to the Editor will be limited to comments on contributions already published n the journal;
if a letter is accepted, a response (for simultaneous publication) will be invited from the authors of the original contribution.
Manuscripts are accepted for review with the understanding that they describe original research performed by authors, that all
authors approve of the submission, and that the manuscript is not being considered for publication elsewhere. By submitting the manuscript,
the authors agree that, if accepted for publication, copyright of the complete article will be assigned to the publisher.
Furthermore,
it is understood that with submission of this article the authors have complied with the institutional policies governing the humane
and ethical treatment of the experimental subjects, and that they are willing to share the original data and materials if so requested.
Conflict of Interest and Source of Funding. A conflict of interest exists when an author or the author's institution has a financial
or other relationship with other people or organizations that may inappropriately influence the author's actions. All submissions to Food and Chemical Toxicology must include disclosure of all relationships that could be viewed as presenting a potential conflict
of interest. Food and Chemical Toxicology may use such information as a basis for editorial decisions and may publish such disclosures
if they are believed to be important to readers in judging the article.
Conflict of Interest Statements for Authors.Food
and Chemical Toxicology requires full disclosure of all potential conflicts of interest. Please download the disclosure from
the Food and Chemical Toxicology web site, http://ees.elsevier.com/fct
at the 'Attach Files' stage of manuscript submission or download the form directly here.
The corresponding author is responsible for downloading and sharing a copy of this form for each and every co-author listed on the manuscript.
Each and every co-author must complete and sign their individual form and return to the corresponding author. The corresponding author
is responsible for uploading their form and those of their co-authors (as one document) at the submission process.
Investigators should
disclose potential conflicts to participants in clinical trials and other studies and should state in the manuscript whether they have
done so. Food and Chemical Toxicology may decide not to publish on the basis of a declared conflict, such as the financial interest
of an author in a company (or its competitors) that makes a product discussed in the paper.
Submission of Manuscripts. It
is a condition of publication that all manuscripts must be submitted in English to Food and Chemical Toxicology's submission
and review website, http://ees.elsevier.com/fct. Authors are requested to transmit the text and art of the manuscript in
electronic form to this address. Each manuscript must also be accompanied by a cover letter outlining the basic findings of the paper
and their significance. The Editors welcome submissions by the authors of the names and addresses of up to five individuals who could
expertly review the paper, and who are not from the same institutions as the authors. The Editors, reserve the right to use these or
other reviewers. Should you be unable to provide an electronic version, please contact the editorial offices prior to submission:
Managing
Editor for rest of the World: Alan Boobis a.boobis@ic.ac.uk
Brief Communications
Preliminary but exciting
break-through findings may be published in this expedited review process. This manuscript must be limited to eight double-spaced pages
and generally follow the same format as full papers. The need for rapid publication of the data must be clearly stated in the Introduction.
Brevity is not a justification for Brief Communication status.
Reviews
Informative reviews of contemporary topics in
toxicology relevant to the scope of the journal are welcomed. They should be concise and, in any event, no longer than 80 pages double-spaced,
including references, table and figures. Authors should follow the general advice given above for manuscripts, but reviews do not need
to follow the sectional format recommended for research papers. Reviews should include a Title page, Abstract, Introduction and Discussion/Conclusions,
in addition to the core of the review. A contents page is not necessary unless the author(s) consider that would be helpful in a lengthy
review.
Manuscript Format
Manuscripts should be written in clear and concise English; incomprehensible manuscripts will
be returned to the authors for rewriting. Manuscripts should be double spaced throughout, with at least 2.5-cm margins. All pages must
be numbered, including the title page. Title page: • Title: Titles consisting of declarative or interrogative
sentences are not acceptable. Titles may not include trademarked names or abbreviations. • Authors: Provide surnames and initials
of all authors • Institution(s) where the work was done (with the affiliation of each author clearly indicated) • Corresponding
author: Provide full name and complete contact information including mailing address, telephone number, fax number and email. •
Running title: This will be printed at the top of each page of the manuscript; not to exceed 45 characters including spaces. •
Keywords: Please provide no more than six keywords • Abbreviations: Any abbreviations used should be listed in alphabetical
order under Abbreviations as a footnote to the title page.
Abstract
The abstract should be a self-contained summary
of the objectives, results and significance of the study, not exceeding 200 words. Uninformative sentences such as "the significance
of the results is discussed" are not acceptable. Introduction
Provide a concise and clear statement on the background,purposes
and significance of the work including objectives. Materials and Methods
This section should be a description of the
experimental design and of any new or improved methods. Provide sufficient detail such that experienced researchers would be able to
duplicate the experiments. Well established methods and techniques may be identified by reference only. Test substances must
be adequately characterized and should include chemical name, CAS registry Number, EU Number, common or usual name and purity. If the
test substance is an extract, the following information must be provided: scientific and common name of the source, detailed extraction
procedure, concentration of active principle(s) (if known), standardization of batches, and stability. Details are necessary to permit
clear identification and to allow replication of results by other investigators. Animals must be specified by species, strain,
sex, age, weight (mean ± SD or SE), housing conditions and number per group.
It is recommended but not required that safety
evaluation studies that conform to recognized existing guidelines (e.g. OECD) and follow GLP or GCP procedures should be so noted. Results
Should be presented concisely, with the aid of tables or figures where appropriate. Tables should include indications
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A succinct
interpretation of the data. Appropriate speculation and a brief discussion of further research are encouraged but must be brief. Extensive
literature reviews and highly speculative comment are discouraged. Acknowledgements
Provide recognition of sources of
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since authorship should be limited to those who have made a major contribution to the study and to the preparation of the paper. Authors
are advised to obtain approval for the wording of any acknowledgement from those whose help is noted.
All sources of funding (for
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should be a heading that clearly identifies the data therein. Data should be expressed as mean + SE or SD, and noted as such.
Tables consisting of negative data only (no statistically significant dose-dependent effects) are strongly discouraged. Illustrations
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If figures that have already been published under copyright are to be reproduced in the Journal (e.g. in reviews), copies of letters
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CAS names being used, wherever possible with the aid of CAS Registry and EC numbers. Pesticides should be referred to be their ISO names
and human and veterinary drugs by their INNs. Gene accession numbers In the electronic version of a published manuscript,
gene accession numbers will be linked directly to the gene's description in NCBI's Nucleotide sequence database. The accession number
should be formatted as follows:
Accession no. AJ315850
and in the text e.g. ". . . at the amino acid sequence level to the human
IDN3 gene (Accession No. AJ315850)."
The production department will then link this reference when they find it in the text. Authors
should DOUBLE-CHECK the number they use to make absolutely sure that it is correct before referring to it in their paper. Accession numbers
in proofs should also always be checked for correctness. The number is an essential part of the link. Abbreviations
These
should be used sparingly; they should be defined when first used in the paper but also listed in alphabetical order under Abbreviations
as a footnote to the title page (see above).
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than one paper from the same author(s) in the same year should be identified by the letters a,b,c, etc., after the year of publication.
Examples: • Pereira, M.A. and Chang, L.W., 1981. Binding of chemical carcinogens and mutagens to rat hemoglobin. Chem.- Biol.
Interact. 22, 301-305. • Weisburger, E.K., 1988. Carcinogenic halogenated aliphatic compounds. In: P. Politzer and F.J. Martin,
Jr. (Eds), Chemical Carcinogens. Activation Mechanisms, Structural and Electronic Factors, and Reactivity, Elsevier, Amsterdam, pp. 91-113.
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