The Nobel Prize in Physiology or Medicine 2008

 

This year the Nobel Prize in Physiology or Medicine was divided between two discoveries of viruses involved in diseases that affect global health. External link  Harald zur Hausen from Germany received one half for his discovery of “human papilloma viruses (HPV) causing cervical cancer” and the other half went jointly to External link  Francoise Barre-Sinoussi and External link  Luc Montagnier from France for their discovery of “Human immunodeficiency virus (HIV)”, the cause of AIDS.

Zur Hausen published most of his highly cited articles in Elsevier journals, and his discovery has ultimately led to the development of prophylactic vaccines against HPV acquisition.

In recognition of the importance of their work, we are pleased to make the laureates’ key articles published with Elsevier freely available:

Harard zur Hausen

zur Hausen, H.
External link  Perspectives of contemporary papillomavirus research
(2006) Vaccine, 24 (SUPPL. 3), pp. iii-iv.

De Villiers, E.-M., Fauquet, C., Broker, T.R., Bernard, H.-U., Zur Hausen, H.
External link  Classification of papillomaviruses
(2004) Virology, 324 (1), pp. 17-27.

Zur Hausen, H.
External link  Immortalization of human cells and their malignant conversion by high risk human papillomavirus genotypes
(1999) Seminars in Cancer Biology, 9 (6), pp. 405-411.

Zur Hausen, H.
External link  Papillomavirus infections - A major cause of human cancers
(1996) Biochimica et Biophysica Acta - Reviews on Cancer, 1288 (2), pp. F55-F78.

De Villiers, E.-M., Wagner, D., Schneider, A., Wesch, H., Munz, F., Miklaw, H., Zur Hausen, H.
External link  Human papillomavirus DNA in women without and with cytological abnormalities: Results of a 5-year follow-up study
(1992) Gynecologic Oncology, 44 (1), pp. 33-39.

Zur Hausen, H.
External link  Human genital cancer: Synergism between two virus infections or synergism between a virus infection and initiating events?
(1982) Lancet, 2 (8312), pp. 1370-1372.

 


Francoise Barre-Sinoussi

Coëffier, E., Clément, J.-M., Cussac, V., Khodaei-Boorane, N., Jehanno, M., Rojas, M., Dridi, A., Latour, M., El Habib, R., Barré-Sinoussi, F., Hofnung, M., Leclerc, C.
External link  Antigenicity and immunogenicity of the HIV-1 gp41 epitope ELDKWA inserted into permissive sites of the MalE protein
(2000) Vaccine, 19 (7-8), pp. 684-693.

Müller-Trutwin, M.C., Corbet, S., Dias Tavares, M., Hervé, V.M.A., Nerrienet, E., Georges-Courbot, M.-C., Saurin, W., Sonigo, P., Barré-Sinoussi, F.
External link  The evolutionary rate of nonpathogenic simian immunodeficiency virus (SIVagm) is in agreement with a rapid and continuous replication in vivo
(1996) Virology, 223 (1), pp. 89-102.

Barré-Sinoussi, F.
External link  HIV as the cause of AIDS
(1996) Lancet, 348 (9019), pp. 31-35.

Spire, B., Sire, J., Zachar, V., Rey, F., Barre-Sinoussi, F., Galibert, F., Hampe, A., Chermann, J.-C.
External link  Nucleotide sequence of HIV1-NDK: A highly cytopathic strain of the human immunodeficiency virus
(1989) Gene, 81 (2), pp. 275-284.

Ono, K., Nakane, H., Fukushima, M., Chermann, J.-C., Barré-Sinoussi, F.
External link  Inhibition of reverse transcriptase activity by a flavonoid compound, 5,6,7-trihydroxyflavone
(1989) Biochemical and Biophysical Research Communications, 160 (3), pp. 982-987.

Ellrodt, A., Le Bras Ph., Barre-Sinoussi, F.
External link  Isolation of human T-lymphotropic retrovirus (LAV) from Zairian married couple, one with AIDS, one with prodromes
(1984) Lancet, 1 (8391), pp. 1383-1385.

 


Luc Montagnier

Zennou, V., Petit, C., Guetard, D., Nerhbass, U., Montagnier, L., Charneau, P.
External link  HIV-1 genome nuclear import is mediated by a central DNA flap
(2000) Cell, 101 (2), pp. 173-185.

Quillent, C., Oberlin, E., Braun, J., Rousset, D., Gonzalez-Canali, G., Métais, P., Montagnier, L., Virelizier, J.-L., Arenzana-Seisdedos, F., Beretta, A.
External link  HIV-1-resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene
(1998) Lancet, 351 (9095), pp. 14-18.

Blanchard, A., Montagnier, L., Gougeon, M.-L.
External link  Influence of microbial infections on the progression of HIV disease
(1997) Trends in Microbiology, 5 (8), pp. 326-331.

Khatissian, E., Monceaux, V., Cumont, M.-C., Montagnier, L., Hurtrel, B., Chakrabarti, L.
External link  Interferon-gamma expression in macaque lymph nodes during primary infection with simian immunodeficiency virus
(1996) Cytokine, 8 (11), pp. 844-852.

Lopez, O., Bonnefont-Rousselot, D., Mollereau, M., Olivier, R., Montagnier, L., Emerit, J., Gentilini, M., Delattre, J.
External link  Increased plasma thiobarbituric acid-reactive substances (TBARS) before opportunistic infection symptoms in HIV infected individuals
(1996) Clinica Chimica Acta, 247 (1-2), pp. 181-187.

Chakrabarti, L., Baptiste, V., Khatissian, E., Cumont, M.-C., Aubertin, A.-M., Montagnier, L., Hurtrel, B.
External link  Limited viral spread and rapid immune response in lymph nodes of macaques inoculated with attenuated simian immunodeficiency virus
(1995) Virology, 213 (2), pp. 535-548.

 

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