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Nobel Prize in Medicine - Mario R. Capecchi, Sir Martin J. Evans and Oliver Smithies

M.R. Capecchi
for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells".

By merging two distinct discoveries, Capecchi, Smithies and Evans together developed a technique called gene targeting that allows any gene in the mouse genome to be inactivated...

 
Sir M.J. Evans
...Two of the first papers demonstrating the power of gene targeting were published in Cell (Thomas et al., 1986; Thomas and Capecchi, 1987).

Mice with one or more inactivated genes (so-called knockout mice) have proved enormously valuable as they reveal not only the normal functions of genes but also the diseases that may result when specific genes are shut down...

 
O. Smithies
...About half of the genes in the mouse genome have now been knocked out (inactivated) and there are more than 500 mouse models of human diseases ranging from cardiovascular disease to cancer and diabetes. Capecchi, Smithies and Evans continue to publish exciting research on mouse models of human disease engineered using their innovative gene targeting technique.

 
Please click External linkhere for a selection of articles by Capecchi, Smithies and Evans

 
  

External link  Nobel Prize Website

External link  Video 2007 Award Ceremony

 

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