ANIMAL AND TRANSLATIONAL MODELS FOR CNS DRUG DISCOVERY, 1-3
3: Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders, 3
Edited By Robert McArthur, Associate Professor of Research, Consultant Behavioral Pharmacologist, McArthur & Associates GmbH, Basel, Switzerland Franco Borsini, Head, Central & Peripheral Nervous System and General Pharmacology Area - R&D Department, sigma-tau SpA, Pomezia (Rome), Italy
Description The use of appropriate models can minimize the number of drug candidates that later fail in human trials by accurately predicting the
efficacy and the toxicity of each compound. This can be improved with more informed selection of the appropriate models. This book provides
disorder-specific guidelines for understanding the selection and use of non-human models for trials in the drug discovery and development
process. Reward Deficit Disorders is written for researchers in both academia and the pharmaceutical industry who use animal
models in research and development of drugs for reward deficit disorders such as anti-obesity drugs, medication for heroin and cocaine
addiction and more.
This is the third volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5,
and is also available for purchase individually.
Contents Preface to Reward Deficit Disorders Volume:
What Do You Mean By ?Translational Research?? An Enquiry through Animal and Translational
Models for CNS Drug Discovery: Reward Deficit Disorders
Robert A McArthur and Franco Borsini
1. C. Heidbreder. Impulse and
Reward Deficit Disorders: Drug Discovery and Development
2. D. McCann et al. Drug Discovery and Development for Reward Disorders:
Views from Government
3. T. Gardner et al. Issues in Designing and Conduction Clinical Trails for Reward Disorders: A Clinical
View
4. G. Koob. The Role of Animal Models in Reward Deficit Disorders: Views of Academia
5. Hilary J Little et al.
Pharmacotherapy of Alcohol Dependence: Improving Translation from the Bench to the Clinic
6. A. Markou et al. Contribution
of Animal Models and Preclinical Human Studies to Medication: Development for Nicotine Dependence
7. B. Rocha et al. Development
of Medication for Heroin and Cocaine Addiction and Regulatory Aspects of Abuse Liability Testing
8. C. Dourish et al. Anti-obesity
Drugs: From Animal Models to Clinical Efficacy
9. W. Williams et al. Current Concepts in the Classification, Treatment and
Modeling of Pathological Gambling and other Impulse Control Disorders
Epilogue:
Translational Models for the 21st century: Reminiscence,
Reflections and Some RecommendationsPaul Willner, Franco Borsini, and Robert A McArthur
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