ANIMAL AND TRANSLATIONAL MODELS FOR CNS DRUG DISCOVERY, 1-3
2: Animal and Translational Models for CNS Drug Discovery: Neurological Disorders, 2
Edited By Robert McArthur, Associate Professor of Research, Consultant Behavioral Pharmacologist, McArthur & Associates GmbH, Basel, Switzerland Franco Borsini, Head, Central & Peripheral Nervous System and General Pharmacology Area - R&D Department, sigma-tau SpA, Pomezia (Rome), Italy
Description The use of appropriate models can minimize the number of drug candidates that later fail in human trials by accurately predicting the
efficacy and the toxicity of each compound. This can be improved with more informed selection of the appropriate models. This book provides
disorder-specific guidelines for understanding the selection and use of non-human models for trials in the drug discovery and development
process. Neurological Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models
in research and development of drugs for neurological disorders such as Parkinson's disease, epilepsies, ALS and more.
This is the second
volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, and is also available for purchase
individually.
Contents Preface: What Do You Mean By ?Translational Research?? An Enquiry through Animal and Translational Models for CNS Drug Discovery: Neurological
Disorders
Robert A McArthur and Franco Borsini
1. A. Jackie Hunter. Animal and Translational Models of Neurological Disorders:
An Industrial Perspective
2. Lon S Schneider. Issues in Design and Conduct of Clinical Trials for Cognitive-Enhancing Drugs
3. C. Shilyansky et al. Molecular And Cellular Mechanisms Of Learning Disabilities: A Focus On Neurofibromatosis Type I
4. M. Lindner et al. Development, Optimization and Use of Preclinical Behavioral Models to Maximize the Productivity of Drug Discovery
for Alzheimer's Disease
5. K. Merchant et al. Animal Models of Parkinson's Disease to Aid Drug Discovery and Development
6. T. Wagner et al. Huntington Disease
7. J. Montes. Translational Research in ALS
8. H. Klitgaard. Animal
and Translational Models of the Epilepsies
Epilogue:
Translational Models for the 21st century: Reminiscence, Reflections and Some Recommendations
Paul Willner, Franco Borsini, and Robert A McArthur
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