ANIMAL AND TRANSLATIONAL MODELS FOR CNS DRUG DISCOVERY, 1-3
1: Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders, 1
Edited By Robert McArthur, Associate Professor of Research, Consultant Behavioral Pharmacologist, McArthur & Associates GmbH, Basel, Switzerland Franco Borsini, Head, Central & Peripheral Nervous System and General Pharmacology Area - R&D Department, sigma-tau SpA, Pomezia (Rome), Italy
Description The use of appropriate models can minimize the number of drug candidates that later fail in human trials by accurately predicting the
efficacy and the toxicity of each compound. This can be improved with more informed selection of the appropriate models. This book provides
disorder-specific guidelines for understanding the selection and use of non-human models for trials in the drug discovery and development
process. Psychiatric Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models
in research and development of drugs for psychiatric disorders such as anxiety, depression, and schizophrenia.
This is the first volume
in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, and is also available for
purchase individually.
Contents Preface to Psychiatric Disorders Volume:
What Do You Mean By ?Translational Research?? An Enquiry through Animal and Translational Models
for CNS Drug Discovery: Psychiatric DisordersRobert A McArthur and Franco Borsini
1. Mark J. Millan. The Discovery
and Development of Pharmacotherapy for Psychiatric Disorders: A Critical Survey of Animal and Translational Models, and Perspectives
for their Improvement
2. L. Winsky et al. Drug Discovery and Development Initiatives at the National Institute of Mental Health:
From Cell-Based System to Proof of Concept
3. J. McEvoy and Freudenreich. Issues in the Design and Conductance of Clinical
Trials
4. Klaus A. Miczek. Challenges for Translational Psychopharmacology Research – The Need for Conceptual Principles
5. T. Steckler et al. Developing Novel Anxiolytics: Improving Preclinical Detection and Clinical Assessment
6. D. Joel et
al. Animal Models of Obsessive-Compulsive Disorder: From Bench to Beside Via Endophenotypes and Biomarkers
7. J. Cryan et
al. Developing More Efficacious Antidepressant Medications:
Improving and Aligning Preclinical and Clinical Assessment Tools
8. D. Jones et al. Developing New Drugs for Schizophrenia: From Animals to the Clinic
9. C. Large et al. Developing Therapeutics
for Bipolar Disorder (BPD): From Animal Models to the Clinic
10. R. Tannock et al. Towards a Biological Understanding of ADHD
and the Discovery of Novel Therapeutic Approaches
11. J. Bartz et al. Preclinical Animal Models of Autistic Spectrum Disorders
(ASD)
12. S. Doran et al. Translational Models of Sleep and Sleep Disorders
Epilogue:
Translational Models for the 21st
century: Reminiscence, Reflections and Some RecommendationsPaul Willner, Franco Borsini, and Robert A McArthur
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