James Fox, Massachusetts Institute of Technology, Cambridge, U.S.A. Stephen Barthold, Center for Comparative Medicine, UC Davis School of Veterinary Medicine, Davis CA Muriel Davisson, The Jackson Laboratory, Bar Harbor, Maine Christian Newcomer, Research Animal Resources and Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD Fred Quimby, Laboratory Animal Research Center, The Rockefeller University, New York, NY Abigail Smith, School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA
Description Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely
new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model
of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In
large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to
mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of
immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response
from the development of lymphoid tissues to signal transduction pathways in activated cells.
Contents Volume IV Immunology
1. The Molecular Basis of Lymphoid Architecture in the Mouse
Carola G. Vinuesa and Matthew C. Cook
2. The Biology
of Toll-like Receptors in Mice
Osamu Takeuchi and Shizuo Akira
3. Genomic Organization of the Mouse Major Histocompatibility Complex
Attila Kumanovics
4. Some Biological Features of Dendritic Cells in the Mouse
Kang Liu, Anna Charalambous and Ralph M. Steinman
5.
Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch
Recombination of Immunoglobulin Genes
Maria
D. Iglesias-Ussel, Ziqiang Li, and Matthew D. Scharff
6. Mouse Natural Killer Cells: Function and Activation
Francesco Colucci
7.
Cytokine-activated JAK-STAT Signaling in the Mouse Immune System
Bin Liu and Ke Shuai
8. Signal Transduction Events Regulating Integrin
Function and T Cell Migration in the Mouse
Lakshmi R. Nagarajan and Yoji Shimizu
9. Mouse Models of Negative Selection
Troy A. Baldwin,
Timothy K. Starr and Kristin A. Hogquist
10. Peripheral Tolerance of T Cells in the Mouse
Vigo Heissmeyer, Bogdan Tanasa, and Anjana
Rao
11. The Genetics of Mouse Models of Systemic Lupus
Srividya Subramanian and Edward K. Wakeland
12. Inhibitory Receptors and Autoimmunity
in the Mouse
Menna R. Clatworthy and Kenneth G.C. Smith
13. Mouse Models of Immunodeficiency
B. Anne Croy, James P. Di Santo, Marcus
Manz, and Richard B. Bankert
14. Mouse Models to Study the Pathogenesis of Allergic Asthma
Chad E. Green, Nicholas J. Kenyon, Scott
I. Simon, and Fu-Tong Liu
15. The Mouse Trap: How Well Do Mice Model Human Immunology?
Javier Mestas and Christopher C.W. Hughes
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