Edited by D.A. Lawrence, New York State Department of Health, NY, USA
Description
Volume 5 provides current knowledge regarding the intricacies of the immune system and the manner by which environmental agents can
disrupt immune homeostasis and induce pathologies. The volume begins with an introduction to the field of immunotoxicology and an overview
of the immune system. This is followed by a description of the cellular components of the immune system and how their development and
reactivities can be modified. The architecture of the immune system is described as well as immunology, e.g. pulmonary and mucosal immunology.
Immune functions specifically delineated include cell trafficking, processing of antigens, the manner by which cells communicate and
are signaled into activation from plasma membrane events through to transcriptional events. The immunopathologies resultant from hypersensitivities
are presented with emphasis on the mechanistic means by which chemicals can modify health.
Animal and human examples of autoimmune
diseases are presented as well as the immune changes that occur with aging. Immunosuppression induced by cancers and drugs used for treatment
of cancers and transplant patients are reviewed along with the immunotoxicities associated with biological response modifiers. The ability
of stressors to modify immune functions help describe the importance of neuroimmunological investigations. The immunoregulatory properties
of stress response proteins are also reviewed. The volume concludes with methods and applications utilized for risk assessment and the
consequences of immunotoxicological analysis of humans.
Contents
Immunotoxicology: the merger of immunology and toxicology (D.A. Lawrence). Overview of the immune system (W.O. Weigle). T-cell development
(A.E. Silverstone). B-cell development (K.A. Dorshkind). Natural killer cells (R.J. Smialowicz). Phagocytes (D.L. Laskin, J.D. Laskin).
Lymphoid tissue architecture and pathological influences of toxicants (J.G. Vos, C.F. Kuper, H.-J. Schuurmand). Pulmonary immunology
(D.E. Bice). Mucosal immunology (S.W. Burchiel, D.R. Davila). Skin immunology (S.E. Ullrich). Neuroimmunology (V.M. Sanders). The immunology
of pregnancy (L.J. Guilbert, M.I.G. Horet). Leukocyte trafficking (M.A. Jutila). Antigen processing and presentation (S.K. Pierce, P.H.
Shafer). Lymphocyte Antigen Receptor and Coreceptor Regulation of Tyrosine Kinases and Phosphatases: Effects of Oxidative Stress on Receptor
Functions (J.A. Ledbetter, G.L. Schieven). Signal transduction pathways in B lymphocytes (R.J. Noelle). T cell regulatory functions (M.J.
McCabe Jr). The regulation of B cell activation through cogante interactions with T helper cells and the actions of T cell-dervied soluble
mediators (E.C. Snow). Regulation of transcription by immunotoxicants (B. Freed, L. Geiselhart). Antibody-mediated hypersensitivity (M.H.
Karol, C. Graham). Chemically induced allergy and autoimmunity: what do T cells react against? (P. Grein, E. Gleichmann, C.F. Shaw III).
Hypersensitivity reactions in the lung (J.F. Regal). Contact hypersensitivity (I. Kimber). Autoimmune models (L. Pelletier, S. Ramanathan,
P. Druet). Environmental and drug-induced autoimmune diseases of humans (N.R. Rose, P.P. Caturegli). Aging and the immune system (N.A.
Wade). Immunotoxicology of cancer and prospects for its correction (J.W. Hadden). Immunosuppressive drug and toxicant effects on transplant
recipients (S.E. Hughes, S.A. Gruber). Immunotoxicology of recombinant DNA-derived Therapeutic proteins (G.L. Warner, H.G. Haggerty).
Cytotoxic T cells (N.I. Kerkvliet, L.B. Steppan). Stress and immune function (J.N. Carlson). Immunomodulation by toxicant-induced stress
proteins (M.A. Lynes). Immunotoxicological methods and applications: animal models (M.I. Luster, P.P. Simeonova, D.R. Germolec, A. Bruccoleri).
Bibliographic & ordering Information Hardbound,
ISBN: 0-08-042970-X, 534 pages, publication date: JUL-1997
Imprint: PERGAMON Price: Order form EUR 162 USD 161.95
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