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| COMPREHENSIVE TOXICOLOGY
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Volume 3: Biotransformation
Edited by
F.P. Guengerich, Vanderbilt University School of Medicine, Nashville, TN, USA
Description
This volume deals with the enzymatic processes involved in the biotransformation of toxic and potentially toxic chemicals. The first
section provides introductory material on general aspects of history, regulation, mechanism, inhibition, and stimulation of the enzymes
in this group. The bulk of the volume is comprised of chapters dealing with the current status of enzymes involved in oxidation, reduction,
hydrolysis, and conjugation of xenobiotic chemicals. Each chapter is organized to cover the current status of enzyme multiplicity and
nomenclature, gene and protein structure, regulation, catalytic mechanism, substrate specificity, human studies, and relevance to issues
in toxicology.
Contents
Introduction and historical overview (F.P. Guengerich). Enzyme regulation (M.R. Waterman, F.P. Guengerich). Mechanisms of enzyme catalysis
(F.P. Guengerich). Enzyme inhibition and stimulation (J.R. Halpert, F.P. Guengerich). Cytochrome P450 enzymes (F.P. Guengerich). Monamine
oxidase and flavin-containing monooxygenases (J.R. Cashman). Aldehyde dehydrogenases (D. Peterson, R. Lindahl). Alcohol dehydrogenases
(W.F. Bosron, H.J. Edenberg). Aldo-keto reductases: Structure, Mechanism, and Function (T.G. Flynn, T.J. Kubiseski). Peroxidases (L.J.
Marnett, L.M. Landino, G.R. Reddy). Xanthine dehydrogenase and aldehyde oxidase (K.V. Rajagopalan). Quinone reductases (D. Ross). Superoxide
dismutases (J.M. McCord, J.C. Marecki). Catalase (R.G. Thurman, J.A. Handler). Selenium-dependent glutathione peroxidases (R.F. Burk).
Esterases of the α/β hydrolase fold family (D.M. Quinn). Microsomal amidases and carboxylesterases (T. Sone, C.Y. Wang). Epoxide
hydrolases (B.D. Hammock, D.H. Storms, D.F. Grant). Glutathione transferases (R.N. Armstrong). Enzymes involved in processing of glutathione
conjugates (A.J.L. Cooper, S.S. Tate). Sulfotransferases (M.W. Duffel). Acetyltransferases (K.P. Vatsis, W.W. Weber). UDP-glucuronosyltransferases
(B. Burchell, K. McGurk, C.H. Brierley, D.J. Clark). Methyl transfd. Enzymes involved in formation of amide bonds (D.A. Vessey). Enzymes
involved llular sequestration of metals (M.G. Cherian).
| Bibliographic & ordering Information |
Hardbound, 528 pages, publication date: JUL-1997
ISBN: 0-08-042968-8
Imprint: PERGAMON
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| Price and Ordering |
Price:
EUR 162
USD 161.95
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