Edited by J.A. Bond, Chemical Industry Institute of Toxicology, Research Triangle Park, NC, USA
Description
Volume 1 provides the reader with a basic overview of the field of toxicology. The volume is divided into four sections: 1) introduction,
2) toxicokinetics, 3) mechanisms of toxicity, and 4) risk assessment. The volume provides an in-depth coverage of the field of toxicokinetics
including exposure assessment, routes of exposure of toxicants, and distribution, biotransformation, and excretion of toxicant. Dosimetry
modeling, including physiologically based pharmacokinetic models, and extrapolation modeling are covered. The volume also covers key
mechanisms associated with toxicity/carcinogenicity of chemicals. Concepts of risk assessment are also discussed in this volume. The
contents of Volume 1 lays the ground work for subsequent volumes of the Comprehensive Toxicology series where different aspects
of the field of toxicology are extensively discussed.
Contents
Introduction to the principles of toxicology (D.L. Eaton, E.P. Gallagher). Exposure analysis and its assessment (P.J. Lioy). Toxicokinetics:
oral exposure and absorption of toxicants (C.T. Walsh). Toxicokinetics: inhalation exposure and absorption of toxicants (M.A. Medinsky,
P.M. Schlosser, B. Asgarian). Toxicokinetics: dermal exposure and absorption of toxicants (R.C. Wester, H.I. Maibach). Toxicokinetics:
distribution of toxicants (E.J. O'Flaherty). Toxicokinetics: biotransformation of toxicants (G.L. Kedderis). Toxicokinetics: routes of
elimination (D.E. Rickert). Toxicokinetics: concepts of dose (A.R. Dahl). Toxicokinetics: modeling disposition (G. Johanson). Toxicologic
interactions of chemical mixtures (R.S.H. Yang). Experimental models for the investigation of toxicological mechanisms (D. Acosta, R.L.
Grant, M.A. Smith). Cytolethality: necrosis vs. apoptosis (M. Treinen Moslen, A. Badakumaran). Mitogenesis (R.C. Cattley, B.G. Lake).
The calcium messenger system (J.G. Pounds, M.J. McCabe). Mechanisms: free radicals and reactive oxygen species (J.P. Kehrer). DNA-reactive
agents (A. Dipple). Risk assessment (J.V. Rodricks).
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