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| COMPREHENSIVE TOXICOLOGY
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Volume 12: Chemical Carcinogens and Anticarcinogens
Edited by
G.T. Bowden, University of Arizona Medical School, Tucson, AZ, USA
S.M. Fischer, University of Texas, M.D. Anderson Cancer Center, Smithville, TX, USA
Description
The purpose of Volume 12 is to provide a comprehensive overview of the field of chemical and radiation carcinogenesis with particular
emphasis on molecular mechanisms. The actions of various chemical carcinogens as well as ultraviolet and ionizing radiation are discussed
in the context of the multistage process of both experimental and human carcinogenesis. Background information concerning the target
genes for the genetic and epigenetic modulation by carcinogens are covered. These target genes include proto-oncogenes, tumor suppressor
genes, and effector genes. Various classes of carcinogens including tumor initiating, promoting, and progressing agents are discussed
in terms of how they bring about critical alterations in the target genes. The functional role of these gene alterations are covered
in the context of the various phenotypic changes associated with each stage of carcinogenesis. Finally, strategies for intervening with
the multistep process of carcinogenesis through chemoprevention are discussed. Wherever possible the relevancy of more basic findings
with experimental model systems to human carcinogenesis is emphasized.
Contents
Introduction to neoplasia (R.B. Nagle). Biological aspects of multistage carcinogenesis as studied in experimental animals and in cell
culture models (M.F. Kulesz-Martin). Somatic mutation theory of carcinogenesis (Y.P. Dragan). Photo-oncogenes as potential targets for
the action of carcinogens (G.T. Bowden). Tumor suppressor genes as potential targets for the action of carcinogenesis (A. Balmain). Carcinogenic
alkylating agents (J.A. Swenberg, D.K. La). Carcinogenic aromatic and amides/amines (K.B. Delclos, F.F. Kadlubar). Carcinogenic polycyclic
aromatic hydrocarbons (W.M. Baird, S.L. Ralston). Carcinogenic mycotoxins (T.W. Kensler, J.D. Groopman). Carcinogenic inorganic chemicals
(R.P. Farrell, M. Costa). Ultraviolet light as a carcinogen (H.N. Ananthaswamy). Ionizing radiation as a carcinogen (S.J. Garte). Hormones
and cancer (J.G. Liehr). Tumor promoters and models of promotion (J.E. Rundhaug, S.M. Fischer, G.T. Bowden). Cellular and molecular mechanisms
of tumor promotion (S.M. Fischer). Mechanisms of tumor progression (C.J. Conti). The role of cell proliferation in the etiology of neoplasia
(S.M. Cohen). Genetic determinants of cancer susceptibility (J. DiGiovanni). Chemoprevention of cancer (H. Fujiki, A. Amura).
| Bibliographic & ordering Information |
Hardbound, 498 pages, publication date: JUL-1997
ISBN: 0-08-042977-7
Imprint: PERGAMON
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| Price and Ordering |
Price:
EUR 162
GBP 108
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