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THE REGULATORY GENOME
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Gene Regulatory Networks In Development And Evolution
To order this title, and for more information, click here
By
Eric Davidson, California Institute of Technology, Pasadena, U.S.A.
Reviews
"The Regulatory Genome offers evo-devo aficionados an intellectual masterpiece to praise or to pan but impossible to ignore.
Although there is clearly still much to learn about the evolution of gene networks and how these in turn constrain evolution, Davidson
has placed a cornerstone for the comparative analysis of gene regulatory networks. Further research in this rather fresh field promises
to help delineate the links between development and evolution." – Detlev Arendt, Developmental Biology Programme, European Molecular
Biology Laboratory, Germany in SCIENCE
"...a highly informative book, provocative in the best sense of the word, and very much at the
forefront of the field of developmental biology in the 'post-genomic' era. I recommend it highly to anyone interested in the subject."
- Igor B. Dawid, Laboratory of Molecular Genetics, National Institute of Child Health and
Human Development, NIH, in THE FASEB JOURNAL
"...Davidson does an excellent job of reducing the complexity of different developmental pathways and modes of embryonic development
in diverse animal phyla to a set of simplified and logical concepts and principles. He provides excellent illustrations and experimental
examples derived from several model organisms: nematode worms, fruitflies, sea urchins, tunicates and vertebrates of different sorts.
What is especially attractive about the book are the regulatory networks drawn as simple wiring and computational diagrams. These go
a long way towards explaining the basic regulatory logic and engineering principles of some of the most complex biological phenomena:
animal development and the evolution of body forms.
This book should be read by all biologists who want to understand how development
and evolution take place and what governs the workings of genomes. I also recommend it to computer scientists and engineers who are interested
in the budding field of computational biology, as reading it does not require an extensive background in developmental biology."
- Michael
Karin, University of California San Diego School of Medicine, in NATURE
"Every step of [Eric Davidson's] logic is presented with examples
to explain his idea, with beautiful, well-designed color figures. His concept of the significant roles of gene regulatory networks in
development and evolution can be clearly understood using the aforementioned key terms....I strongly recommend this book to young scientists
with multidisciplinary talents, who will advance the author?s idea of the regulatory genome into its next phase, a voyage into the sea
of genome complexity...reading this book is a pleasure, as it allows us to touch the incredible spirit of a very tough scientist. Davidson
has developed his idea of the gene regulatory network in development and evolution for more than 35 years and has raised it finally to
the level of a real paradigm."
- Nori Satoh, Department of Zoology, Kyoto University, Japan, in NATURE GENETICS
"Prof. Davidson achieves
a remarkable synthesis of key concepts in genomics, embryology, and evolutionary biology. He makes a persuasive case for the importance
of regulatory networks in revealing the logic of complex developmental processes. The book is at the cusp of traditional disciplines
in the biological sciences and the emerging field of computational biology. We finally have a book that reduces complex phenomena to
basic principles, and then describes how these principles can explain among the most remarkable phenomena in nature: animal development
and evolution."
- Mike Levine, University of California, Berkeley, U.S.A.
"Eric Davidson is one of the real pioneers in deciphering
the mysteries of development...This is a milestone work that needs to be read by every biologist interested in development, evolution
and a systems view of life – for it provides deep insights into each of these areas." – Lee Hood, Institute for Systems Biology,
Seattle,
WA, U.S.A.
"Davidson's book is tightly written with an impressive coverage of the field...I don't see how one can grasp the rapidly
changing views of gene regulation and its evolution without a close study of Davidson's book." – Douglas H. Erwin, National Museum of
Natural History, Washington D.C., U.S.A.
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