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| ENZYME KINETICS AND MECHANISM, PART D: DEVELOPMENTS IN ENZYME DYNAMICS, 249
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To order this title, and for more information, click here
John Abelson, California Institute of Technology, Division of Biology, Pasadena, U.S.A.
Daniel Purich, University of Florida, Gainesville, U.S.A.
Melvin Simon, California Institute of Technology, Division of Biology, Pasadena, USA
Description
General Description of the Volume:
This volume, as do the other Enzyme Kinetics and Mechanism volumes in the Methods in Enzymology series, provides treatment of dynamic and chemical approaches for investigating enzyme catalysis
and regulation, as well as designing metabolic inhibitors. It will greatly interest those involved in enzyme chemistry, metabolic control,
and drug design. It should also interest those developing commercial applications for enzymes whose properties have been re-engineered
using recombinant DNA technology and site-directed mutagenesis.General Description of the Series:
The critically acclaimed
laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications
in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and
reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly
an essential publication for researchers in all fields of life sciences.
Audience
Biochemists; biophysicists; molecular biologists; physical chemists; pharmacologists; analytical, organic, and medicinal chemists; biotechnologists; and graduate students in these areas.
Contents
General Approaches to Biological Catalysis:
C.A. Fierke and G.G. Hammes, Transient Kinetic Approaches to Enzyme
Mechanisms.K.A. Johnson, Rapid Quench Kinetic Analysis of Polymerases, Adenosinetriphosphatases, and Enzyme Intermediates.
R.G. Duggleby, Analysis of Enzyme Progress Curves by Nonlinear Regression.B.V. Plapp, Site-Directed Mutagenesis: A
Tool for Studying Enzyme Catalysis.
Inhibitors as Mechanistic Probes:
H.J. Fromm, Reversible Enzyme Inhibitors
as Mechanistic Probes.S.E. Szedlacsek and R.G. Duggleby, Kinetics of Slow and Tight-Binding Inhibitors.W.W. Cleland,
Kinetic Method for Determination of Dissociation Constants of Metal Ion(Nucleotide Complexes.B.F.Cooper and F.B. Rudolph, Product
Inhibition Applications.K.L. Rebholz and D.B. Northrop, Kinetics of Iso Mechanisms.R.B. Silverman, Mechanism-Based
Enzyme Inactivators.A. Radzicka and R. Wolfenden, Transition State and Multisubstrate Analog Inhibitors.
Isotopic Probles
of Enzyme Action:
I.A. Rose, Partition Analysis: Detecting Enzyme Reaction Cycle Intermediates.W.W. Cleland,
Isotope Effects: Determination of Enzyme Transition State Structure.B.J. Bahnson and J.P. Klinman, Hydrogen Tunneling in Enzyme
Catalysis.L.S. Mullins and F.M. Raushel, Positional Isotope Exchange as Probe of Enzyme Action.M.-D. Tsai, R.-T. Jiang,
T. Dahnke, and Z. Shi, Manipulating Phosphorus Stereospecificity of Adenylate Kinase by Site-Directed Mutagenesis.F.C. Wedler,
Equilibrium Isotope Exchange in Enzyme Catalysis.D.N. Silverman, Proton Transfer in Carbonic Anhydrase Measured by Equilibrium
Isotope Exchange.
Kinetics of Specialized Systems:
J.D. Stewart, I. Lee, B.A. Posner, and S.J. Benkovic, Expression
of Properly Folded Catalytic Antibodies in Escherichia coli.K.E. Neet, Cooperativity in Enzyme Function: Equilibrium
and Kinetic Aspects.M.K. Jain, M.H. Gelb, J. Rogers, and O.G. Berg, Kinetic Basis for Interfacial Catalysis by Phospholipase
A2.
Author Index.
Subject Index.
| Bibliographic details |
Hardbound, 662 pages, publication date: MAR-1995
ISBN-13: 978-0-12-182150-0
ISBN-10: 0-12-182150-1
Imprint: ACADEMIC PRESS
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