By
Steven Marsh, Anthony Nolan Research Institute, London, U.K.
Peter Parham, Stanford University School of Medicine, Palo Alto, California, U.S.A.
Linda Barber, Anthony Nolan Research Institute, London, U.K.
Description
The
HLA FactsBook presents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to
both beginner and expert alike. The focus of the book is on the polymorphic HLA genes (HLA-A, B, C, DP, DQ, and DR) that are typed for
in clinical HLA laboratories. Each gene has a dedicated section in which individual entries describe the structure, functions, and population
distribution of groups of related allotypes. Fourteen introductory chapters provide a beginner's guide to the basic structure, function,
and genetics of the HLA genes, as well as to the nomenclature and methods used for HLA typing. This book will be an invaluable reference
for researchers studying the human immune response, for clinicians and laboratory personnel involved in clinical and forensic HLA typing,
and for human geneticists, population biologists, and evolutionary biologists interested in HLA genes as markers of human diversity.
Audience:
Researchers and research clinicians in immunology, immunohematology, genetics, cell and molecular biology, transplantation medicine, autoimmunity,
and biochemistry; researchers working in tissue typing laboratories, cancer biology, developmental biology, and researchers involved
in genome mapping and sequencing; rheumatologists, endocrinologists, and physicians working on HLA-associated diseases; pharmaceutical
industries working on HLA antibodies and kits.
