Description Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one
of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and
in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie
behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly,
the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of
very successful drugs targeting the serotoninergic system include Prozac and Zoloft.
The last decades of research have not only fundamentally
expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude
of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented
in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research
contributing to our present understanding of the brains function during normal and disturbed behaviour.
This handbook aims towards
a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to
date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create
a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology,
physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this
field. Most of them have already written excellent reviews in their field of expertise.
The book is divided in 4 sections. After an
historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will
focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system
and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while
section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders.
Audience
neuroscientists, pharmacologists, psychiatrists, neurologists and psychologists in academia, medical institutions, pharmaceutical industry. Level: Graduate student and up. Suited for advanced courses in behavioral genetics, behavioral pharmacology, behavioral neuroscience
and psychiatry as a reference and supplementary reading material (particularly the on-line version will be useful).
Contents Section 1: Functional anatomy of the serotonergic system Evolution of serotonin: sunlight to suicide
Efrain C. Azmitia Genetic organisation of the serotonergic system Ursula M. D?Souza and Ian W. Craig The neuronatomy of the serotonergic system Jean-Pierre Hornung Ultrastructure of the serotonin innervation
in mammalian central nervous system Laurent Descarries Mustapha Riad and Martin Parent Classification and
signaling characteristics of 5-HT receptors Joel Bockaert, Sylvie Claeysen, Aline Dumuis and Philippe Marin Distribution
of 5-HT receptors in the central nervous system Guadalupe Mengod, Roser Cortes, M. Teresa Vilaro and Daniel Hoyer Measuring serotonin activity in vivo in the brains of animals and humans Charles A Marsden Section 2: The neurophysiology of serotonin 2.1 Activity of brain serotonergic neurons in relation to physiology and behavior Barry L. Jacobs and Casimir A. Fornal 2.2 Electrophysiology of serotonin receptors Gerard J. Marek 2.3 Tryptophane
hydroxylase and serotonin synthesis regulation Hiroyuki Hasegawa and Kazuhiro Nakamura 2.4 The degradation of serotonin:
role of MAO Marco Bortolato, Kevin Chen and Jean C Shih 2.5 Cellular effects of serotonin in the CNS Rodrigo Andrade
and Sheryl G. Beck 2.6 Serotonergic feedback control Trevor Sharp 2.7 Tryptophan depletion and serotonin release
- a critical reappraisal Matthijs G.P. Feenstra and Geoffrey van der Plasse 2.8 Serotonin interaction with other transmitter
systems Albert Adell, Analia Bortolozzi, Llorenc Diaz-Mataix, Noemi Santana, Pau Celada, and Francesc Artigas 2.9 Serotonergic
regulation of rhythmical activity of the brain, concentrating on the hippocampus Robert P. Vertes 2.10 5-HT neurons and
central CO 2 chemoreception Carolin I. Dohle and George B. Richerson Section 3: Serotonin and behavioural
control 3.1 Serotonin and development Patricia M. Whitaker-Azmitia 3.2 Serotonin and basal sensory: motor control Robert J. Carey 3.3 Role of the serotonergic system in appetite and ingestion control Michelle D. Lee and Peter G. Clifton 3.4 Serotonin and sexual behavior Lynda Uphouse and Jutatip Guptarak 3.5 Serotonin in mood and emotion Julie
G. Hensler 3.6 Serotonin and the neurobiology of anxious states Christopher A. Lowry and Matthew W. Hale 3.7 Role
of Serotonin in Brain Reward and Regulation of Alcohol Drinking Behavior W. J. McBride 3.8 Role of central serotonin in
impulsivity and compulsivity: Comparative studies in experimental animals and humans TW Robbins & MJ Crockett 3.9
Experimental studies on the role(s) of serotonin in learning and memory functions Jean-Christophe Cassel 3.10 Social behavior
and serotonin Elif Aysimi Duman and Turhan Canli 3.11 Serotonin in pain and pain control Claudia Sommer Section 4: Serotonin in disease conditions 4.1 The Impact of Stress on Serotonergic Neurotransmission Astrid C.E. Linthorst
and Johannes M.H.M. Reul 4.2 Role for serotonin in depression Gregory V. Carr and Irwin Lucki 4.3 The role of serotonin in drug addiction Christian P. Muller, Martin E. Pum, Gunter Schumann and Joseph P. Huston 4.4
The serotonergic system in obsessive compulsive disorders Addy van Dijk, Andre Klompmakers, and Damiaan Denys 4.5 The role
of serotonin in attention-deficit hyperactivity disorder (ADHD) Robert D. Oades 4.6 Serotonin and schizophrenia Boris
B. Quednow, Mark A. Geyer, and Adam L. Halberstadt 4.7 Serotonin and serotonin receptors in hallucinogen action Adam L.
Halberstadt and David E. Nichols 4.8 The role of serotonin in cortical development: implications for Autism Spectrum Disorder
[ASD] Christine F. Hohmann and Mary E. Blue 4.9 Serotonin in panic and anxiety disorders Francisco Silveira Guimar?es,
Helio Zangrossi Jr., Cristina Marta Del Ben and Frederico Guilherme Graeff 4.10 Serotonin and agression Isabel M. Quadros,
Aki Takahashi and Klaus A. Miczek 4.11 Altered serotonin function in anorexia and bulimia nervosa Vikas Duvvuri, Ursula
F Bailer and Walter H Kaye 4.12 Genetic, epigenetic, and environmental factors in serotonin associated disease conditions Eva Friedel & Andreas Heinz 4.13 The Behavioral Genetics of Serotonin: Relevance to Anxiety and Depression Olivia
F. O?Leary and John F. Cryan 4.14 Functional pharmacogenetics of serotonin receptors in psychiatric drug action Olga O.
Yevtushenko, Gavin P. Reynolds
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