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| COMPREHENSIVE MEDICINAL CHEMISTRY II
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Volume 3: DRUG DISCOVERY TECHNOLOGIES
To order this title, and for more information, click here
Edited By
Hugo Kubinyi, University of Heidelberg, Heidelberg, Germany
Description
Reviews the important technologies used in each step of the drug discovery process; target search, target validation, informatics and
databases, structural biology, screening, chemical technologies, and lead search and optimization. Chemists, medicinal chemists and biologists
present clear examinations of each step to help scientists understand the underlying techniques, problems and solutions encountered in
finding a drug target and methods used to test and improve their properties.
Audience
For students and researchers in chemistry, biochemistry, medicinal chemistry and pharmacology and scientists working in the pharmaceutical industries.
Contents
Volume 3 Drug Discovery Technologies
Target Search
3.01 Genomics
3.02 Proteomics
3.03 Pharmacogenomics
3.04 Biomarkers
3.05
Microarrays
3.06 Recombinant Deoxyribonucleic Acid and Protein Expression
3.07 Chemical Biology
Target Validation
3.08 Genetically
Engineered Animals
3.09 Small Interfering Ribonucleic Acids
3.10 Signaling Chains
3.11 Orthogonal Ligand?Receptor Pairs
Informatics
and Databases
3.12 Chemoinformatics
3.13 Chemical Information Systems and Databases
3.14 Bioactivity Databases
3.15 Bioinformatics
3.16
Gene and Protein Sequence Databases
3.17 The Research Collaboratory for Structural Bioinformatics Protein Data Bank
3.18 The Cambridge
Crystallographic Database Structural Biology
Structural Biology
3.19 Protein Production for Three-Dimensional Structural Analysis
3.20
Protein Crystallization
3.21 Protein Crystallography
3.22 Bio-Nuclear Magnetic Resonance
3.23 Protein Three-Dimensional Structure
Validation
3.24 Problems of Protein Three-Dimensional Structures
3.25 Structural Genomics
Screening
3.26 Compound Storage
and Management
3.27 Optical Assays in Drug Discovery
3.28 Fluorescence Screening Assays
3.29 Cell-Based Screening Assays
3.30
Small Animal Test Systems for Screening
3.31 Imaging
3.32 High-Throughput and High-Content Screening
Chemical Technologies
3.33
Combinatorial Chemistry
3.34 Solution Phase Parallel Chemistry
3.35 Polymer-Supported Reagents and Scavengers in Synthesis
3.36
Microwave-Assisted Chemistry
3.37 High-Throughput Purification
Lead Search and Optimization
3.38 Protein Crystallography in
Drug Discovery
3.39 Nuclear Magnetic Resonance in Drug Discovery
3.40 Chemogenomics
3.41 Fragment-Based Approaches
3.42 Dynamic
Ligand Assembly
| Bibliographic details |
Hardbound, 1066 pages, publication date: NOV-2006
ISBN-13: 978-0-08-044516-8
ISBN-10: 0-08-044516-0
Imprint: ELSEVIER
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| Price and Ordering |
Price:
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USD 495
EUR 325
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Last update: 5 Sep 2009
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