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Techniques and Applications for the Clinical Laboratory
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Edited By
Wayne Grody, UCLA School of Medicine, Los Angeles, CA, USA Professor Divisions of Medical Genetics and Molecular Pathology Departments of Path. &
Lab. Medicine, Pediatrics, and Human Genetics UCLA School of Medicine Los Angeles, CA 90095-1732
Robert Nakamura, Scripps Clinic, La Jolla, CA, U.S.A.
Frederick Kiechle, Medical Director, Clinical Pathology Department of Pathology Pathology Consultants of South Broward Memorial Healthcare System
Charles Strom, Medical Director, Genetic Testing Center Nichols Institute, Quest Diagnostics, San Juan Capistrano, CA, U.S.A.
Audience
Pathologists, laboratory technicians, geneticists, physicians, medical students, and other health care professionals involved in molecular testing.
Contents
I. Introduction and Methodology
Quantivative PCR: an introduction
Signal Amplification Methods in
Molecular Diagnostics
The Lab-on-a-Chip Approach for Molecular Diagnostics
Nucleic Extraction and Amplification
General Procedures
II.
Quality Assurance, Regulatory, and Ethical Issues
Billing and Reimbursement for Molecular Diagnostics
Molecular
Pathology and Infectious Diseases
Ethical Considerations in Molecular Diagnostics
Quality Control, Assurance, Identification and
Standards
III. Genetic Disease
Molecular Testing for Cystic Fibrosis and CFTR-Related
Conditions
Carrier Testing for Neurogenetic Diseases
Hemochromatosis
Standards and Recommendations for Molecular Diagnostic
Testing for Huntington Disease, the Autosomal Dominant Spinocerebellar Ataxias, and Friedreich Ataxia
IV.
Cancer
The Role of Micro-RNAs in Cancer
Molecular Diagnostics in the Evaluation of Cancer: Modern Concepts
and Overview
Gene Expression Analysis for Tumor Profiling GEA for TP
Molecular Diagnostics of Hematopoetic Malignancies
V.
Infectious Diseases
Viruses
Hepatic B and C Viruses
Molecular Diagnosis of Cytomegalovirus
Molecular
Detection of Multiple Respiratory Viruses
Bacteria
Molecular Methods for Identification and Characterization of Acinetobacter
species
Molecular Detection and Surveillance of Healthcare-Associated Infections
Molecular Detection Of Group B Streptococcus
Role
of Molecular Techniques in the Epidemiologic Investigation Of Hospital-Acquired Infections
Human Papilloma Virus and its Role in Cervical
Carcinoma
VI. Specialized Applications of Molecular Testing
Molecular HLA Typing Methods
Used in Clinical Laboratories
Identification through DNA analysis in criminal and family relatedness investigations.
VII.
Pharmacogenetics
Overview of Pharmacogenomics and Applications for the Modern Clinical Laboratory
UDP-Glucuronosyltransferase
1A1 and the Glucuronidation in Oncology Applications and Hyperbilirubinemia
Pharmacogenetics of P-450 Enzymes
Pharmacogenomics
of Thiopurine Methyl Transferase (TPMT): Importance in Monitoring of Mercaptopurine/Azathioprine Therapy
| Bibliographic details |
Hardbound, 736 pages, publication date: NOV-2009
ISBN-13: 978-0-12-369428-7
ISBN-10: 0-12-369428-0
Imprint: ACADEMIC PRESS
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EUR 138.95
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Last update: 3 Oct 2009
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