ANIMAL AND TRANSLATIONAL MODELS FOR CNS DRUG DISCOVERY, 1-3
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Edited By Robert McArthur, Associate Professor of Research, Consultant Behavioral Pharmacologist, McArthur & Associates GmbH, Basel, Switzerland Franco Borsini, Head, Central & Peripheral Nervous System and General Pharmacology Area - R&D Department, sigma-tau SpA, Pomezia (Rome), Italy
Description Minimize the number of drug candidates that could later fail in human trials! These three volumes provide a unique examination of how
animal models are evolving from ?behavioral gut baths? to providing cross-species information relevant to human clinical responses.
Each volume provides the views and experiences of leading pre-clinical and clinical investigators who are actively involved in translational
research and experimental medicine.
Each volume is devoted to specific disorders in three scientific fields: Psychiatric, Neurological,
and Reward Deficit.
Audience
Researchers developing drugs for neurological, psychiatric, and reward deficit disorders
Contents VOLUME 1: Pyschiatric Disorders
Preface: What Do You Mean By ?Translational Research?? An Enquiry through Animal and Translational Models
for CNS Drug Discovery: Psychiatric Disorders
Robert A McArthur and Franco Borsini
1. Mark J. Millan. The Discovery and Development
of Pharmacotherapy for Psychiatric Disorders: A Critical Survey of Animal and Translational Models, and Perspectives for their Improvement
2. L. Winsky et al. Drug Discovery and Development Initiatives at the National Institute of Mental Health: From Cell-Based System to
Proof of Concept
3. J. McEvoy and Freudenreich. Issues in the Design and Conductance of Clinical Trials
4. Klaus A. Miczek. Challenges
for Translational Psychopharmacology Research – The Need for Conceptual Principles
5. T. Steckler et al. Developing Novel Anxiolytics:
Improving Preclinical Detection and Clinical Assessment
6. D. Joel et al. Animal Models of Obsessive-Compulsive Disorder: From Bench
to Beside Via Endophenotypes and Biomarkers
7. J. Cryan et al. Developing More Efficacious Antidepressant Medications:
Improving and
Aligning Preclinical and Clinical Assessment Tools
8. D. Jones et al. Developing New Drugs for Schizophrenia: From Animals to the Clinic
9. C. Large et al. Developing Therapeutics for Bipolar Disorder (BPD): From Animal Models to the Clinic
10. R. Tannock et al. Towards
a Biological Understanding of ADHD and the Discovery of Novel Therapeutic Approaches
11. J. Bartz et al. Preclinical Animal Models of
Autistic Spectrum Disorders (ASD)
12. S. Doran et al. Translational Models of Sleep and Sleep Disorders
Epilogue:
Translational Models
for the 21st century: Reminiscence, Reflections and Some Recommendations
VOLUME 2: Neurological Disorders
Preface: What Do You Mean
By ?Translational Research?? An Enquiry through Animal and Translational Models for CNS Drug Discovery: Neurological Disorders
Robert
A McArthur and Franco Borsini
1. A. Jackie Hunter. Animal and Translational Models of Neurological Disorders: An Industrial Perspective
2. Lon S Schneider. Issues in Design and Conduct of Clinical Trials for Cognitive-Enhancing Drugs
3. C. Shilyansky et al. Molecular
And Cellular Mechanisms Of Learning Disabilities: A Focus On Neurofibromatosis Type I
4. M. Lindner et al. Development, Optimization
and Use of Preclinical Behavioral Models to Maximize the Productivity of Drug Discovery for Alzheimer's Disease
5. K. Merchant et al.
Animal Models of Parkinson's Disease to Aid Drug Discovery and Development
6. T. Wagner et al. Huntington Disease
7. J. Montes. Translational
Research in ALS
8. H. Klitgaard. Animal and Translational Models of the Epilepsies
Epilogue:
Translational Models for the 21st century:
Reminiscence, Reflections and Some Recommendations
Paul Willner, Franco Borsini, and Robert A McArthur
VOLUME 3: Reward Deficit Disorders
Preface: What Do You Mean By ?Translational Research?? An Enquiry through Animal and Translational Models for CNS Drug Discovery: Reward
Deficit Disorders
Robert A McArthur and Franco Borsini
1. C. Heidbreder. Impulse and Reward Deficit Disorders: Drug Discovery and Development
2. D. McCann et al. Drug Discovery and Development for Reward Disorders: Views from Government
3. T. Gardner et al. Issues in Designing
and Conduction Clinical Trails for Reward Disorders: A Clinical View
4. G. Koob. The Role of Animal Models in Reward Deficit Disorders:
Views of Academia
5. Hilary J Little et al. Pharmacotherapy of Alcohol Dependence: Improving Translation from the Bench to the Clinic
6. A. Markou et al. Contribution of Animal Models and Preclinical Human Studies to Medication: Development for Nicotine Dependence
7. B. Rocha et al. Development of Medication for Heroin and Cocaine Addiction and Regulatory Aspects of Abuse Liability Testing
8.
C. Dourish et al. Anti-obesity Drugs: From Animal Models to Clinical Efficacy
9. W. Williams et al. Current Concepts in the Classification,
Treatment and Modeling of Pathological Gambling and other Impulse Control Disorders
Epilogue:
Translational Models for the 21st century:
Reminiscence, Reflections and Some Recommendations
Paul Willner, Franco Borsini, and Robert A McArthur
Volumes
1-3: Animal and Translational Models for CNS Drug Discovery, 1-3
1: Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders, 1
2: Animal and Translational Models for CNS Drug Discovery: Neurological Disorders, 2
3: Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders, 3
Bibliographic & ordering Information
1-3 - Animal and Translational Models for CNS Drug Discovery, 1-3 Hardbound, 1376 pages, publication date: OCT-2008
ISBN-13: 978-0-12-373861-5
ISBN-10: 0-12-373861-X
Imprint: ACADEMIC PRESS
Price: USD 200 GBP 120.99 EUR 142.95
1 - Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders, 1 Hardbound, 528 pages, publication date: OCT-2008
ISBN-13: 978-0-12-373856-1
ISBN-10: 0-12-373856-3
Imprint: ACADEMIC PRESS
Price: GBP 50.99 EUR 60.95 USD 84.95
2 - Animal and Translational Models for CNS Drug Discovery: Neurological Disorders, 2 Hardbound, 416 pages, publication date: OCT-2008
ISBN-13: 978-0-12-373855-4
ISBN-10: 0-12-373855-5
Imprint: ACADEMIC PRESS
Price: GBP 50.99 EUR 60.95 USD 84.95
3 - Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders, 3 Hardbound, 432 pages, publication date: OCT-2008
ISBN-13: 978-0-12-373860-8
ISBN-10: 0-12-373860-1
Imprint: ACADEMIC PRESS
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