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| NMR SPECTROSCOPY IN PHARMACEUTICAL ANALYSIS
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Edited By
Iwona Wawer, Medical University of Warsaw, Poland
Ulrike Holzgrabe, University of Wurzburg, Germany
Bernd Diehl, Spectral Service, Germany
Description
For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines,
i. e. drug identification, impurity profiling and assay, qNMR can be utilized.
Separation techniques such as high performance liquid
chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation
of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless
such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in
pharmaceutical analysis.
Beside the introduction to the physical fundamentals and techniques the principles of the application in drug
analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds,
metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug
formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give
more detailed information by means of concrete examples.
Audience
researchers, consultants, practitioners in pharmaceutical industries and licensing authorities; students of pharmacy, chemistry, biochemistry and corresponding applied sciences
Contents
Part I: Fundamentals and Techniques
1. NMR Spectroscopy in drug analysis; application in international pharmacopoieae
and related analyses. (U. Holzgrabe, B. Waibel, C. Schollmayer)
2. Principles in NMR spectroscopy. (B. Diehl)
3. qNMR in solid
state NMR. (I. Wawer)
4. qNMR. (F. Malz)
5. Internal standards for quantification and pattern recognition, e.g. ERETIC; and principal
component analysis of mixtures, e.g. beverages (Amix™). (M. Spraul, E. Humpfer)
6. Microcoil NMR spectroscopy/Nanoliter-Volume
NMR spectroscopy. (A.G. Webb)
Part II: General Applications
7. NMR spectroscopy in impurity profiling including
aspects of pharmacopoeia. (U. Holzgrabe)
8. NMR spectroscopy of pharmaceutical polymers. (B. Diehl)
9. Natural Products analysis
by qNMR. (B. Diehl)
10. Solid-state measurements of drugs and drug formulations. (I. Wawer)
Part III Special Applications
11.
NMR assays for identity of polysaccharides from bacteria used in vaccine manufacture. (C. Jones, N. Ravenscroft)
12. Metabolic profiling.
(C.K. Larive)
13. Fluorine-19 and phosphorus-31 NMR for quantitation of fluorinated and phosphorylated drugs and their metabolites
in biofluids. (M. Malet-Martino)
14. Solid-state measurements of bones. (C. Jager)
15. qNMR for assessing the purity of agrochemicals
(R.J. Wells)
16. Assessment of inhibitory potency of antibiotics by MRI (C. Faber)
17. Quantitation 2D NMR analysis of glycosaminoglycans.
(G. Torri)
18. DOSY NMR for Drug Analysis. (M. Malet-Martino, et al)
19. NMR spectroscopy of peptides as an alternative to AAA.
(E. Kellenbach, K. Sanders, P.L.A. Overbeeke)
20. The Hypernation of NMR and Other Spectroscopies in Drug and Natural Products Research.
(I.D. Wilson)
21. Online-NMR-Spektroscopy. (H. Hasse)
| Bibliographic details |
Hardbound, 528 pages, publication date: AUG-2008
ISBN-13: 978-0-444-53173-5
ISBN-10: 0-444-53173-4
Imprint: ELSEVIER
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| Price and Ordering |
Price:
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EUR 81.95
USD 115
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Last update: 5 Sep 2009
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