By
Jean-Pierre Schermann, Emeritus Professor, University Paris, France
Description
This book presents an overview of recent advances in the intertwining of the following research fields: photon and electron spectroscopy,
quantum chemistry, modelling and mass-spectrometry. The coupling of these disciplines offers a new point of view to the understanding
of isolated elementary building blocks of biomolecules and their assemblies. It allows the unambiguous separation between intrinsic properties
of biomolecular systems and those induced by the presence of their environment.
The first chapters provide background in modelling (I),
frequency-resolved spectroscopy using microwave, infrared and UV photons, time-resolved spectroscopy in the femtosecond domain and energy-resolved
electron spectroscopy (II) and production of gas-phase neutral and ionic biomolecular species, mass-spectrometry, ion mobility and BIRD
techniques (III).
Chapter IV is devoted to case studies of gas-phase experimental investigations coupled to quantum or classical calculations.
The topics are structural studies of nucleobases and oligonucleotides, peptides and proteins, sugars; neuromolecules; non-covalent complexes;
chiral systems, interactions of low-energy electrons with biomolecules in the radiation chemistry context and very large gas-phase biomolecular
systems.
The fifth chapter concerns the link between gas-phase and liquid-phase. Different treatments of solvation are illustrated through
examples pointing out the influence of progressive addition of water molecules upon properties of nucleobases, peptides, sugars and neuromolecules.
Audience:
Researchers in physics, physical chemistry, biophysics, students in physics, physical chemistry, biophysics
