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NELSON TEXTBOOK OF PEDIATRICS
Nelson Textbook of Pediatrics
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Eighteenth Edition

By
Robert Kliegman, MD, Professor and Chair, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
Richard Behrman, MD, Executive Chair, Pediatric Education Steering Committee, Federation of Pediatric Organizations, Menlo Park, CA; Clinical Professor of Pediatrics, Stanford University and the University of California, San Francisco, CA; George Washington University, Washington, DC
Hal Jenson, MD, Chair, Department of Pediatrics, Director, Center for Pediatric Research, and Senior Vice-President for Academic Affairs, Eastern Virginia Medical School and Children's Hospital of the King's Daughters, Norfolk, VA
Bonita Stanton, MD, Schotanus Professor and Chair, Department of Pediatrics, Wayne State University, Detroit, MI, USA

Description
For nearly three quarters of a century, Nelson Textbook of Pediatrics has been the world's most trusted resource for best approaches to pediatric care. Now in full color for easier referencing, this New Edition continues the tradition, incorporating a wealth of exciting updates and changes?ensuring you have access to today's authoritative knowledge to best diagnose and treat every pediatric patient you see. Whether you're treating patients in the office or in the hospital, or preparing for the boards, Nelson Textbook of Pediatrics, 18th Edition is your comprehensive guide to providing the best possible care.

Contents


Part I: The Field of Pediatrics

1 Overview of Pediatrics 2 Quality and Safety in Healthcare for Children 3 Ethics in Pediatric Care 4 Cultural Issues in Pediatric Care 5 Maximizing Children?s Health: Screening, Anticipatory Guidance, and Counseling



Part II: Growth, Development, and Behavior

6 Overview and Assessment of Variability 6.1 Assessment of Fetal Growth and Development 7 The Newborn 8 The First Year 9 The Second Year 10 Preschool Years 11 Middle Childhood 12 Adolescence 13 Sexual Behavior 13.1 The Development of Sexual Behavior 13.2 Gender Identity Disorder (GID) 13.3 Adolescent Homosexuality 14 Assessment of Growth 15 Developmental Screening and Surveillance 16 Child Care: How Pediatricians Can Support Children and Famillies 17 Separation, Loss, and Bereavement 18 Sleep Medicine



Part III: Child and Adolescent Psychology

19 Assessment and Interviewing 20 Psychological Treatment of Children and Adolescents 20.1 Illness and Death 20.2 Psychopharmacology 20.3 Psychotherapy 20.4 Psychiatric Hospitalization 21 Psychosomatic Illness 22 Vegetative Disorders 22.1 Rumination Disorders 22.2 Pica 22.3 Enuresis (Bedwetting) 22.4 Encopresis 23 Habit and Tic Disorders 24 Anxiety Disorders 25 Mood Disorders 25.1 Major Depression 25.2 Dysthymic Disorder 25.3 Bipolar Disorder 26 Suicide and Attempted Suicide 27 Anorexia Nervosa, Bulimia, and Binge Eating 28 Disruptive Behavioral Disorders 29 Pervasive Developmental Disorders and Childhood Psychosis 29.1 Autistic Disorder 29.2 Asperger?s Disorder 29.3 Childhood Disintegrative Disorder 29.4 Rett's Disorder 29.5 Childhood Schizophrenia 29.6 Acute Phobic Hallucinations 30 Patterns of Development and Function in the School-Aged Child 31 Attention Deficit Hyperactivity Disorder 32 Specific Reading Disability 32.1 Language Development and Communication Disorders



PART IV: Children with Special Needs

33 Adoption 34 Foster Care 35 Impact of Violence on Children 35.1 School Violence and Bullying 35.2 Effect of War on Children 36 Abuse and Neglect of Children 36.1 Sexual Abuse 36.2 Munchausen Syndrome by Proxy 36.3 Parental Styles 37 Failure to Thrive 38 Developmental Disabilities and Chronic Illness 38.1 Mental Retardation (Intellectual Disability) 39 Organ Transplantation 40 Pediatric Palliative Care: The Care of Children with Life-Limiting Illness 40.1 Grief and Bereavement



Part V: Nutrition

41 Nutritional Requirements 42 The Feeding of Infants and Children 43 Food Insecurity, Hunger, and Undernutrition 44 Overweight and Obesity 45 Vitamin A Deficiency and Excess 46 Vitamin B Complex Deficiency and Excess 46.1 Thiamin (Vitamin B-1) 46.2 Riboflavin (Vitamin B-2) 46.3 Niacin 46.4 Vitamin B-6 (Pyridoxine) 46.5 Biotin 46.6 Folate 46.7 Vitamin B-12 (Cobalamin) 47 Vitamin C Deficiency (Ascorbic Acid) 48 Rickets and Hypervitaminosis D 49 Vitamin E Deficiency 50 Vitamin K Deficiency 51 Micronutrient Deficiency



Part VI: The Pathophysiology of Body Fluids and Fluid Therapy

52 Electrolyte and Acid-Base Disorders 52.1 Composition of Body Fluids 52.2 Regulation of Osmolality and Volume 52.3 Sodium 52.4 Potassium 52.5 Magnesium 52.6 Phosphorus 52.7 Acid-Base Balance 53 Maintenance and Replacement Therapy 54 Deficit Therapy 55 Fluids and Electrolyte Treatment of Specific Disorders 55.1 Acute Diarrhea and Oral Rehydration 55.2 Diarrhea in Chronically Malnourished Children 55.3 Pyloric Stenosis 55.4 Perioperative Fluids



Part VII: Pediatric Drug Therapy

56 Pharmacogenetics, Pharmacogenomics, and Pharmacoproteins 57 Principles of Drug Therapy 58 Poisonings 59 Herbal Medicines



Part VIII: Critical Care Medicine

60 Evaluation of the Sick Child in the Office and Clinic 61 Injury Control 62 Emergency Medical Services for Children 63 Interfacility Transfer of the Critically Ill Infant and Child 64 Monitoring Techniques for the Critically Ill Infant and Child 65 Scoring Systems and Predictors of Mortality 66 Pediatric Emergencies and Resuscitation 67 Neurologic Emergencies and Stabilization 67.1 Brain Death 68 Shock 69 Respiratory Distress and Failure 70 Mechanical Ventilation 70.1 Chronic Mechanical Ventilation 71 Acute Care of the Multiple Trauma Victim 72 Nutritional Stabilization 73 Drowning 74 Burn injuries 75 Cold Injuries 76 Anesthesia and Perioperative Care 77 Pediatric Pain Management



Part IX: Human Genetics

78 The Genetic Approach in Pediatric Medicine 79 The Human Genome 80 Patterns of Genetic Transmission 81 Cytogenetics 82 Genetics of Common Disorders: Diagnosis and Management 83 Integration of Genetics into Pediatric Practice



Part X: Metabolic Diseases

84 An Approach to Inborn Errors of Metabolism 85 Defects in Metabolism of Amino Acids 85.1 Phenylalanine 85.2 Tyrosine 85.3 Methionine 85.4 Cysteine/Cystine 85.5 Tryptophan 85.6 Valine, Leucine, Isoleucine, and Related Organic Acidemias 85.7 Glycine 85.8 Serine 85.9 Proline 85.1-0 Glutamic Acid 85.11 Urea Cycle and Hyperammonemia (Arginine, Citrulline, Ornithine) 85.12 Histidine 85.13 Lysine 85.14 Aspartic Acid (Canavan Disease) 86 Defects in Metabolism of Lipids 86.1 Disorders of Mitochondrial Fatty Acid β-Oxidation 86.2 Disorders of Very Long Chain Fatty Acids 86.3 Disorders of Lipoprotein Metabolism and Transport: Epidemiology of Blood Lipids and Cardiovascular Disease 86.4 Lipidoses 86.5 Mucolipidoses 87 Defects in Metabolism of Carbohydrates 87.1 Glycogen Storage Diseases 87.2 Defects in Galactose Metabolism 87.3 Defects in Fructose Metabolism 87.4 Defects in Intermediary Carbohydrate Metabolism Associated with Lactic Acidosis 87.5 Defects in Pentose Metabolism 87.6 Disorders of Glycoprotein Degradation and Structure 88 Mucopolysaccharidoses 89 Disorders of Purine and Pyrimidine Metabolism 90 Progeria 91 The Porphyrias 92 Hypoglycemia



Part XI: Perinatal and Neonatal Medicine

93 Overview of Mortality and Morbidity 94 The Newborn Infant 94.1 History in Neonatal Pediatrics 94.2 Physical Examination of the Newborn Infant 94.3 Routine Delivery Room Care 94.4 Nursery Care 94.5 Parent-Infant Bonding 95 High-Risk Pregnancies 96 The Fetus 96.1 Fetal Growth and Maturity 96.2 Fetal Distress 96.3 Maternal Disease and the Fetus 96.4 Maternal Medication and Toxin Exposure and the Fetus 96.5 Teratogens 96.6 Radiation 96.7 Intrauterine Diagnosis of Fetal Disease 96.8 Treatment and Prevention of Fetal Disease 97 The High-Risk Infant 97.1 Multiple Gestation Pregnancies 97.2 Prematurity and Intrauterine Growth Retardation 97.3 Post-Term Infants 97.4 Large for Gestational Age 97.5 Infant Transport 98 Clinical Manifestations of Diseases in the Newborn Period 99 Nervous System Disorders 99.1 The Cranium 99.2 Traumatic, Epidural, Subdural, and Subarachnoid Hemorrhage 99.3 Intracranial-Intraventricular Hemorrhage and Periventricular Leukomalacia 99.4 Brain Injury from Inflammation, Infection, and Medications 99.5 Hypoxia-Ischemia 99.6 Spine and Spinal Cord 99.7 Peripheral Nerve Injuries 100 Delivery Room Emergencies 101 Respiratory Tract Disorders 101.1 Transition to Pulmonary Respiration 101.2 Apnea 101.3 Congenital Central Hypoventilation Syndrome 101.4 Respiratory Distress Syndrome (Hyaline Membrane Disease) 101.5 Transient Tachypnea of the Newborn 101.6 Aspiration of Foreign Material (Fetal Aspiration Syndrome, Aspiration Pneumonia) 101.7 Meconium Aspiration 101.8 Persistent Pulmonary Hypertension of the Newborn (Persistent Fetal Circulation) 101.9 Diaphragmatic Hernia 101.10 Foramen of Morgagni Hernia 101.11 Paraesophageal Hernia 101.12 Eventration 101.13 Extrapulmonary Extravasation of Air (Pneumothorax, Pneumomediastinum, Pulmonary Interstitial Emphysema) 101.14 Pulmonary Hemorrhage 102 Digestive System Disorders 102.1 Meconium Ileus in Cystic Fibrosis 102.2 Neonatal Necrotizing Enterocolitis (NEC) 102.3 Jaundice and Hyperbilirubinemia in the Newborn 102.4 Kernicterus 103 Blood Disorders 103.1 Anemia in the Newborn Infant 103.2 Hemolytic Disease of the Newborn (Erythroblastosis Fetalis) 103.3 Plethora in the Newborn Infant (Polycythemia) 103.4 Hemorrhage in the Newborn Infant 104 Genitourinary System 105 The Umbilicus 106 Metabolic Disturbances 106.1 Maternal Selective Serotonin Reuptake Inhibitors and Neonatal Behavioral Syndromes 106.2 Fetal Alcohol Syndrome 107 The Endocrine System 107.1 Infants of Diabetic Mothers 107.2 Hypoglycemia 108 Dysmorphology 109 Infections of the Neonatal Infant 109.1 Pathogenesis and Epidemiology 109.2 Modes of Transmission and Pathogenesis 109.3 Immunity 109.4 Etiology of Fetal and Neonatal Infection 109.5 Epidemiology of Early- and Late-Onset Neonatal Infections 109.6 Clinical Manifestations of Transplacental Intrauterine Infections 109.7 Diagnosis 109.8 Treatment 109.9 Complications and Prognosis 109.1'0 Prevention



Part XII: Adolescent Medicine

110 The Epidemiology of Adolescent Health Problems 111 Delivery of Health Care to Adolescents 111.1 Legal Issues 111.2 Screening Procedures 111.3 Health Enhancement 112 Violent Behavior 113 Substance Abuse 113.1 Alcohol 113.2 Tobacco 113.3 Marijuana 113.4 Volatile Inhalants 113.5 Hallucinogens 113.6 Cocaine 113.7 Amphetamines 113.8 Opiates 113.9 Anabolic Steroids 114 The Breast 115 Menstrual Problems 115.1 Amenorrhea 115.2 Abnormal Uterine Bleeding 115.3 Dysmenorrhea 115.4 Premenstrual Syndrome 116 Contraception 116.1 Barrier Methods 116.2 Spermicides 116.3 Combination Methods 116.4 Hormonal Methods 116.5 Emergency Contraception 116.6 Intrauterine Devices 117 Adolescent Pregnancy 118 Adolescent Rape 119 Sexually Transmitted Infections 120 Chronic Fatigue Syndrome



Part XIII: Immunology

Section 1: Evaluation of the Immune Systems 121 Evaluation of Suspected ImmunodeficiencySection 2: The T-, B-, and NK-Cell Systems 122 T Lymphocytes, B Lymphocytes, and Natural Killer Cells 123 Primary Defects of Antibody Production 123.1 Treatment of B-Cell Defects 124 Primary Defects of Cellular Immunity 125 Primary Combined Antibody and Cellular Immunodeficiencies 125.1 Severe Combined Immunodeficiency (SCID) 125.2 Combined Immunodeficiency (CID) 125.3 Defects of Innate Immunity 125.4 Treatment of Cellular or Combined Immunodeficiency 125.5 Immune Dysregulation with Autoimmunity or LymphoproliferationSection 3: The Phagocytic System 126 Neutrophils 127 Monocytes and Macrophages and Dendritic Cells 128 Eosinophils 129 Disorders of Phagocyte Function 130 Leukopenia 131 Leukocytosis Section 4: The Complement System 132 The Complement System 133 Disorders of the Complement System 133.1 Evaluation of the Complement System 133.2 Genetic Deficiencies of Complement Components 133.3 Deficiencies of Plasma, Membrane, or Serosal Complement Control Proteins 133.4 Secondary Disorders of Complement 133.5 Treatment of Complement DisordersSection 5: 134 Principles and Clinical Indications 135 HSCT from Alternative Sources and Donors 136 Graft vs Host Disease (GVHD) and Rejection 137 Infectious Complications of HSCT 138 Late Effects of HSCT



Part XIV: Allergy

139 Allergy and the Immunologic Basis of Atopic Disease 140 Diagnosis of Allergic Disease 141 Principles of Treatment of Allergic Disease 142 Allergic Rhinitis 143 Childhood Asthma 144 Atopic Dermatitis (Atopic Eczema) 145 Insect Allergy 146 Ocular Allergies 147 Urticaria and Angioedema (Hives) 148 Anaphylaxis 149 Serum Sickness 150 Adverse Reactions to Foods 151 Adverse Reactions to Drugs



Part XV: Rheumatology

152 Evaluation of Suspected Rheumatic Disease 153 Treatment of Rheumatic Diseases 154 Juvenile Rheumatoid Arthritis 155 Ankylosing Spondylitis and Other Spondyloarthropathies 156 Reactive Arthritis 157 Systemic Lupus Erythematosus 157.1 Neonatal Lupus 158 Juvenile Dermatomyositis 159 Scleroderma and Raynaud Syndrome 160 BehVet?s Disease 161 Sjogren?s Syndrome 162 Hereditary Periodic Fever Syndromes 163 Amyloidosis 164 Sarcoidosis 165 Kawasaki Disease 166 Vasculitis Syndromes 166.1 Henoch-Schonlein Purpura 166.2 Takayasu Arteritis 166.3 Polyarteritis Nodosa 166.4 Wegener Granulomatosis 166.5 Other Vasculitic Syndromes 167 Musculoskeletal Pain Syndromes 167.1 Fibromyalgia 167.2 Complex Regional Pain Syndrome (Reflex Sympathetic Dystrophy 167.3 Erythromelalgia 168 Miscellaneous Conditions Associated With Arthritis



Part XVI: Infectious Diseases

Section 1. General Considerations 169 Diagnostic MicrobiologySection 2. Preventive Measures (NEW) 170 (NEW) Immunization Practices 170.1 (NEW) International Immunization Practices 171 Infection Control and Prophylaxis 172 Childcare and Communicable Diseases 173 Health Advice for Children Traveling Internationally 174 Fever 175 Fever Without a Focus 176 Sepsis, Septic Shock, and System Inflammatory Response Syndrome (SIRS) 177 Infections in Immunocompromised Persons 178 Infections Associated with Medical DevicesSection 3. Antibiotic Therapy (NEW) 179 Principles of Antibacterial Therapy Section 4. Gram-Positive Bacterial Infections 180 Staphylococcus 180.1 Staphylococcus aureus 180.2 Toxic Shock Syndrome 180.3 Coagulase-Negative Staphylococci 181 Streptococcus pneumoniae (Pneumococcus) 182 Group A Streptococcus 182.1 Rheumatic Fever 183 Group B Streptococcus 184 Non?Group A or B Streptococcus 184 Enterococcus 186 Diphtheria (Corynebacterium diphtheriae) 187 Listeria monocytogenes 188 Actinomyces 189 NocardiaSection 5. Gram Negative Bacterial Infections 190 Neisseria meningitidis (Meningococcus) 191 Neisseria gonorrhoeae (Gonococcus) 192 Haemophilus influenzae 193 Chancroid (Haemophilus ducreyi) 194 Pertussis (Bordetella pertussis and B. parapertussis) 195 Salmonella 195.1 Nontyphoidal Salmonellosis 195.2 Enteric Fever (Typhoid Fever) 196 Shigella 197 Escherichia coli 198 Cholera (Vibrio cholerae) 199 Campylobacter 200 Yersinia 200.1 Yersinia enterocolitica 200.2 Yersinia pseudotuberculosis 200.3 Plague (Yersinia pestis) 201 Aeromonas and Plesiomonas 201.1 Aeromonas 201.2 Plesiomonas shigelloides 202 Pseudomonas, Burkholderia, and Stenotrophomonas 202.1 Pseudomonas aeruginosa 202.2 Burkholderia 202.3 Stenotrophomonas 203 Tularemia (Francisella tularensis) 204 Brucella 205 Legionella 206 Bartonella 206.1 Bartonellosis (Bartonella bacilliformis) 206.2 Cat-Scratch Disease (Bartonella henselae) 206.3 Trench Fever (Bartonella quintana) 206.4 Bacillary Angiomatosis and Bacillary Peliosis Hepatis (Bartonellahenselae and Bartonella quintana)Section 6: Anaerobic Bacterial Infections 207 Botulism (Clostridium botulinum) 208 Tetanus (Clostridium tetani) 209 Pseudomembranous Colitis (Clostridium difficile) 210 Other Anaerobic InfectionsSection 7: Mycobacterial Infections 211 (NEW) Principles of Antimycobacterial Therapy 212 Tuberculosis (Mycobacterium tuberculosis) 213 Hansen Disease (Mycobacterium leprae) 214 Nontuberculous MycobacteriaSection 8. Spirochectal Infections 215 Syphilis (Treponema pallidum) 216 Nonvenereal Treponemal Infections 216.1 Yaws (Treponema pertenue) 216.2 Bejel Endemic Syphilis (Treponema pallidum subsp. endemicum) 216.3 Pinta (Treponema carateum) 217 Leptospira 218 Relapsing Fever (Borrelia) 219 Lyme Disease (Borrelia burgdorferi)Section 9. Mycroplasmal Infections 220 Mycoplasma pneumoniae 221 Genital Mycoplasmas (Mycoplasma hominis, Mycoplasma Genitalium, and Ureaplasma urealyticum)Section 10. Chlamydial Infections 222 Chlamydiophila pneumoniae 223 Chlamydia trachomatis 223.1 Trachoma 223.2 Genital Tract Infections 223.3 Conjunctivitis and Pneumonia in Newborns 223.4 Lymphogranuloma Venereum (LGV) 224 Psittacosis (Chlamydia psittaci)Section 11. Rickettsial Infections 225 Spotted Fever Group Rickettsioses 225.1 Rocky Mountain Spotted Fever (Rickettsia rickettsii) 225.2 Mediterranean Spotted Fever or Boutonneuse Fever (Rickettsia conorii) 225.3 Rickettsialpox (Rickettsia akari) 226 Scrub Typhus (Orientia tsutsugamushi) 227 Typhus Group Rickettsioses 227.1 Murine Typhus (Rickettsia typhi) 227.2 Epidemic Typhus (Rickettsia prowazekii) 228 Ehrlichioses and Anaplasmosis 229 Q Fever (Coxiella burnetii)Section 12. Fungal Infections 230 Principles of Antifungal Therapy 231 Candida 231.1 Neonatal Infections 231.2 Infections in Immunocompetent Children and Adolescents 231.3 Infections in Immunocompromised Children and Adolescents 231.4 Chronic Mucocutaneous Candidiasis 232 Cryptococcus neoformans 233 Malassezia 234 Aspergillus 234.1 Hypersensitivity Syndromes 234.2 Saprophytic (Noninvasive) Syndromes 234.3 Invasive Disease 235 Histoplasmosis (Histoplasma capsulatum) 236 Blastomycosis (Blastomyces dermatitidis) 237 Coccidioidomycosis (Coccidioides immitis) 238 Paracoccidioides brasiliensis 239 Sporotrichosis (Sporothrix schenckii) 240 Zygomycosis (Mucormycosis) 241 Pneumocystis carinii (P. jiveci)Section 13. Viral Infections 242 Principles of Antiviral Therapy 243 Measles 244 Rubella 245 Mumps 246 Polioviruses 247 Nonpolio Enteroviruses 248 Parvovirus B19 249 Herpes Simplex Virus 250 Varicella-Zoster Virus 251 Epstein-Barr Virus 252 Cytomegalovirus 253 Roseola (Human Herpesviruses 6, 7) 254 Human Herpesvirus 8 255 Influenza Viruses 256 Parainfluenza Viruses 257 Respiratory Syncytial Virus 258 Human Metapneumovirus 259 Adenoviruses 260 Rhinoviruses 261 Coronavirus 261.1 Severe Acute Respiratory Syndrome (SARS)-associated corona virus 262 Rotaviruses, Calicivirus, and Astrovirus (new title) 263 Human Papillomaviruses 264 Arboviral Encephalitis in North America 265 Arboviral Encephalitis Outside North America 265.1 Venezuelan Equine Encephalitis 265.2 Japanese Encephalitis 265.3 Tick-Borne Encephalitis 266 Dengue Fever and Dengue Hemorrhagic Fever 267 Yellow Fever 268 Other Viral Hemorrhagic Fevers 269 Lymphocytic Choriomeningitis Virus (LCMV) 270 Hantavirus Pulmonary Syndrome 271 Rabies 272 Polyomaviruses (JC virus and BK Virus) 273 Acquired Immunodeficiency Syndrome (Human Immunodeficiency Virus) 274 Human T-Cell Lymphotropic Viruses Types I and II 275 Transmissible Spongiform Encephalopathies Section 14. Antiparasitic Therapy (NEW)276 Principles of Antiparasitic TherapySection 15. Protozoan Diseases 277 Primary Amebic Meningoencephalitis 278 Amebiasis 279 Giardiasis and Balantidiasis 279.1 Giardia lamblia 279.2 Balantidiasis 280 Cryptosporidium, Isospora, Cyclospora, and Microsporidia 281 Trichomoniasis (Trichomonas vaginalis) 282 Leishmaniasis (Leishmania) 283 African Trypanosomiasis (Sleeping Sickness; Trypanosoma brucei complex) 284 American Trypanosomiasis (Chagas Disease; Trypanosoma cruzi) 285 Malaria (Plasmodium) 286 Babesiosis (Babesia) 287 Toxoplasmosis (Toxoplasma gondii)Section 16. Helminthic Diseases 288 Ascariasis (Ascaris lumbricoides)289 Hookworms (Necator americanus and Ancylostoma) 289.1 Cutaneous Larva Migrans 290 Trichuriasis (Trichuris trichuria) 291 Enterobiasis (Enterobius vermicularis) 292 Strongyloidiasis (Strongyloides stercoralis) 293 Lymphatic Filariasis (Brugia malayi, B. timori, and Wuchereria bancrofti) 294 Other Tissue Nematodes 295 Toxocariasis (Visceral and Ocular Larva Migrans) 296 Trichinosis (Trichinella spiralis) 297 Schistosomiasis (Schistosoma) 298 Flukes (Liver, Lung, and Intestinal) 299 Adult Tapeworm Infections 300 Cysticercosis 301 Echinococcosis (Echinococcus granulosus and E. multilocularis)



Part XVII: The Digestive System

Section 1. Clinical Manifestations of Gastrointestinal Disease 302 Normal Digestive Tract Phenomena 303 Major Symptoms and Signs of Digestive Tract DisordersSection 2. The Oral Cavity 304 Development and Developmental Anomalies of the teeth 305 Disorders of the Oral Cavity Associated with Other Conditions 306 Malocclusion 307 Cleft Lip and Palate 308 Syndromes with Oral Manifestations 309 Dental Caries 310 Periodontal Diseases 311 Dental Trauma 312 Common Lesions of the Oral Soft Tissues 313 Diseases of the Salivary Glands and Jaws 314 Diagnostic Radiology in Dental AssessmentSection 3. The Esophagus 315 Embryology, Anatomy, and Function of the Esophagus 315.1 Common Clinical Manifestations and Diagnostic Aids 316 Congenital Anomalies: Esophageal Atresia and Tracheoesophageal Fistula 316.1 Congenital Anomalies: Laryngotracheoesophageal Clefts 317 Obstructing and Motility Disorders of the Esophagus 318 Dysmotility 319 Hiatal Hernia 320 Gastroesophageal Reflux Disease (GERD) 320.1 Complications of GERD 321 Non-GERD Esophagitis 322 Esophageal Perforation 323 Esophageal Varices 324 Ingestions 324.1 Foreign Bodies in the Esophagus 324.2 Caustic IngestionsSection 4. Stomach and Intestines 325 Normal Development, Structure, and Function 326 Pyloric Stenosis and Other Congenital Anomalies of the Stomach 326.1 Hypertropic Pyloric Stenosis 326.2 Congenital Gastric Outlet Obstruction 326.3 Gastric Duplication 326.4 Gastric Volvulus 326.5 Hypertrophic Gastropathy 327 Intestinal Atresia, Stenosis, and Malrotation 327.1 Duodenal Obstruction 327.2 Jejunal and Ileal Atresia and Obstruction 327.3 Malrotation 328 Intestinal Duplications, Meckel Diverticulum, and Other Remnants of the Omphalomesenteric Duct 328.1 Intestinal Duplication 328.2 Meckel Diverticulum and Other Remnants of the Omphalomesenteric Duct 329 Motility Disorders and Hirschsprung Disease 329.1 Chronic Intestinal Pseudo-Obstruction 329.2 Functional Constipation 329.3 Congenital Aganglionic Megacolon (Hirschsprung Disease) 329.4 Intestinal Neuronal Dysplasia 329.5 Superior Mesenteric Artery Syndrome, Wilkie Syndrome, Cast Syndrome, Arteriomesenteric Duodenal Compression Syndrome 330 Ileus, Adhesions, Intussusception, and Closed-Loop Obstructions 330.1 Ileus 330.2 Adhesions 330.3 Intussusception 330.4 Closed-Loop Obstructions 331 Foreign Bodies and Bezoars 331.1 Foreign Bodies in the Stomach and Intestine 331.2 Bezoars 332 Peptic Ulcer Disease in Children 332.1 Zollinger-Ellison Syndrome 333 Inflammatory Bowel Disease 333.1 Chronic Ulcerative Colitis 333.2 Crohn Disease (Regional Enteritis, Regional lleitis, Granulomatous Colitis) 333.3 Behcet Syndrome 334 Food Allergy (Food Hypersensitivity) 334.1 Eosinophilic Gastroenteritis 335 Disorders of Malabsorption 335.1 Evaluation of Children with Suspected Intestinal Malabsorption 335.2 Gluten-Sensitive Enteropathy (Celiac Disease) 335.3 Other Malabsorptive Sydromes 335.4 Intestinal Infections Associated with Malabsorption 335.5 Immunodeficiency Disorders 335.6 Immunoproliferative Small Intestinal Disease 335.7 Short Bowel Syndrome 335.8 Chronic Malnutrition 335.9 Enzyme Deficiencies 335.1-0 Liver and Biliary Disorders Causing Malabsorption 335.11 Defects of Absorption or Transport 336 Intestinal Transplantation in Children 337 Acute Gastroenteritis in Children (new) 337.1 Probiotics in Gastrointestinal Disorders (new) 338 Chronic Diarrhea 338.1 Diarrhea from Hormone-Secreting Tumors 339 Recurrent Abdominal Pain of Childhood 340 Acute Appendicitis 341 Surgical Conditions of the Anus, Rectum, and Colon 341.1 Anorectal Malformations 341.2 Anal Fissure 341.3 Perianal Abscess and Fistula 341.4 Hemorrhoids 341.5 Rectal Prolapse 341.6 Pilonidal Sinus and Abscess 342 Tumors of the Digestive Tract 343 Inguinal Hernias Section 5. Exocrine Pancreas 344 Embryology, Anatomy, and Physiology 344.1 Anatomic Abnormalities 344.2 Physiology 345 Pancreatic Function Tests 346 Disorders of the Exocrine Pancreas 347 Treatment of Pancreatic Insufficiency 348 Pancreatitis 348.1 Acute Pancreatitis 348.2 Chronic Pancreatitis 349 Pseudocyst of the Pancreas 350 Pancreatic TumorsSection 6. The Liver and Biliary System 351 Morphogenesis of the Liver and Biliary System 352 Manifestations of Liver Disease 352.1 Evaluation of Patients with Possible Liver Dysfunction 353 Cholestasis 353.1 Neonatal Cholestasis 353.2 Cholestasis in the Older Child 354 Metabolic Diseases of the Liver 354.1 Inherited Deficient Conjugation of Bilirubin (Familial Nonhemolytic Unconjugated Hyperbilirubinemia) 354.2 Wilson Disease 354.3 Indian Childhood Cirrhosis 354.4 Neonatal Iron Storage Disease (NISD) 354.5 Miscellaneous Metabolic Diseases of the Liver 355 Viral Hepatitis 356 Liver Abscess 357 Liver Disease Associated with Systemic Disorders 358 Mitochondrial Hepatopathies 359 Autoimmune and Chronic Hepatitis 360 Drug- and Toxin-Induced Liver Injury 361 Fulminant Hepatic Failure 362 Cystic Diseases of the Biliary Tract and Liver 363 Diseases of the Gallbladder 364 Portal Hypertension and Varices 365 Liver TransplantationSection 7. Peritoneum 366 Malformations 367 Ascites 367.1 Chylous Ascites 368 Peritonitis 368.1 Acute Primary Peritonitis 368.2 Acute Secondary Peritonitis 368.3 Acute Secondary Localized Peritonitis (Peritoneal Abscess) 369 Epigastric Hernia 369.1 Incisional Hernia



Part XVIII: Respiratory System

Section 1. Development and Function 370 Respiratory Pathophysiology and Regulation 370.1 Lung Volumes and Capacities in Health and Disease 370.2 Chest Wall 370.3 Pulmonary Mechanics and Work of Breathing in Health and Disease 370.4 Airway Dynamics in Health and Disease 370.5 Interpretation of Clinical Signs to Localize the Site of Pathology 370.6 Ventilation-Perfusion (V/Q) Relationship in Health and Disease 370.7 Gas Exchange in Health and Disease 370.8 Interpretation of Blood Gases 370.9 Pulmonary Vasculature in Health and Disease 370.1-0 Immune Response of the Lung to Injury 370.11 Regulation of Respiration 371 Diagnostic Approach to Respiratory Disease 372 Sudden Infant Death SyndromeSection 2. Disorders of the Respiratory Tract 373 Congenital Disorders of the Nose 374 Acquired Disorders of the Nose 374.1 Foreign Body 374.2 Epistaxis 375 Nasal Polyps 376 The Common Cold 377 Sinusitis 378 Acute Pharyngitis 379 Retropharyngeal Abscess, Lateral Pharyngeal (Parapharyngeal) Abscess, and Peritonsillar Cellulitis/Abscess 380 Tonsils and Adenoids 381 Chronic or Recurrent Respiratory Symptoms 382 Acute Inflammatory Upper Airway Obstruction (Croup, Epiglottitis, Laryngitis, and Bacterial Tracheitis) 382.1 Infectious Upper Airway Obstruction 382.2 Bacterial Tracheitis 383 Congenital Anomalies of the Larynx, Trachea, and Bronchi 383.1 Laryngomalacia 383.2 Congenital Subglottic Stenosis 383.3 Vocal Cord Paralysis 383.4 Congenital Laryngeal Webs and Atresia 383.5 Congenital Subglottic Hemangioma 383.6 Laryngoceles and Saccular Cysts 383.7 Posterior Laryngeal Cleft (PLC) and Laryngotracheoesophageal Cleft (LTEC) 383.8 Vascular and Cardiac Anomalies 383.9 Tracheal Stenoses, Webs, and Atresia 383.1-0 Foregut Cysts 383.11 Tracheomalacia and Bronchomalacia 384 Foreign Bodies of the Airway 384.1 Laryngeal Foreign Bodies 384.2 Tracheal Foreign Bodies 384.3 Bronchial Foreign Bodies 385 Laryngotracheal Stenosis, Subglottic Stenosis 385.1 Congenital Subglottic Stenosis 385.2 Acquired Laryngotracheal Stenosis 386 Bronchomalacia and Tracheomalacia 387 Neoplasms of the Larynx, Trachea, and Bronchi 387.1 Vocal Nodules 387.2 Recurrent Respiratory Papillomatosis (RRP) 387.3 Congenital Subglottic Hemangioma 387.4 Vascular Anomalies 387.5 Other Laryngeal Neoplasms 387.6 Tracheal Neoplasms 387.7 Bronchial Tumors 388 Wheezing, Bronchiolitis, and Bronchitis 388.1 Wheezing in Infants and Bronchiolotis 388.2 Bronchitis 389 Emphysema and Overinflation 390 α1-Antitrypsin Deficiency and Emphysema 391 Other Distal Airway Diseases 391.1 Bronciolitis Obliterans 391.2 Follicular Bronchitis 391.3 Pulmonary Alveolar Microlithiasis 392 Congenital Disorders of the Lung 392.1 Pulmonary Agenesis and Aplasia 392.2 Pulmonary Hypoplasia 392.3 Cystic Adenomatoid Malformation 392.4 Pulmonary Sequestration 392.5 Bronchogenic Cysts 392.6 Congenital Pulmonary Lymphangiectasia 392.7 Lung Hernia 392.8 Other Congenital Malformations of the Lung 393 Pulmonary Edema 394 Aspiration Syndromes 395 Chronic Recurrent Aspiration 396 Parenchymal Disease with Prominent Hypersensitivity, Eosinophilic Infiltration, or Toxin-Mediated Injury 396.1 Hypersensitivity to Inhaled Materials 396.2 Silo Filler Disease 396.3 Paraquat Lung 396.4 Eosinophilic Lung Disease (Formerly Loffler Syndrome) 397 Pneumonia 398 Bronchiectasis 399 Pulmonary Abscess 400 Cystic Fibrosis 401 Primary Ciliary Dyskinesia (Immotile Cilia Syndrome) 402 Interstitial Lung Diseases 403 Pulmonary Alveolar Proteinosis 404 Inherited Disorders of Surfactant Metabolism 405 Pulmonary Hemosiderosis 406 Pulmonary Hemorrhage, Embolism, and Infarction 406.1 Pulmonary Embolus and Infarction 406.2 Pulmonary Hemorrhage and Hemoptysis 407 Atelectasis 408 Pulmonary Tumors 409 Pleurisy 409.1 Dry or Plastic Pleurisy 409.2 Serofibrinous Pleurisy 409.3 Purulent Pleurisy or Empyema 410 Pneumothorax 411 Pneumomediastinum 412 Hydrothorax 413 Hemothorax 414 Chylothorax 415 Bronchopulmonary Dysplasia 416 Skeletal Diseases Influencing Pulmonary Function 416.1 Pectus Excavatum (Funnel Chest) 416.2 Pectus Carinatum and Sternal Clefts 416.3 Asphyxiating Thoracic Dystrophy (Thoracic-Pelvic-Phalangeal Dystrophy) 416.4 Achondroplasia 416.5 Kyphoscoliosis: Adolescent Idiopathic Scoliosis and Congential Scoliosis 416.6 Congenital Rib Anomalies 417 Neuromuscular Diseases with Pulmonary Consequences 418 Extrapulmonary Diseases with Pulmonary Manifestations 419 Chronic Severe Respiratory Insufficiency



Part XIX: The Cardiovascular System

Section 1. Developmental Biology of the Cardiovascular System 420 Cardiac Development 420.1 Early Cardiac Morphogenesis 420.2 Cardiac Looping 420.3 Cardiac Septation 420.4 Aortic Arch Development 420.5 Cardiac Differentiation 420.6 Developmental Changes in Cardiac Function 421 The Fetal to Neonatal Circulatory Transition 421.1 The Fetal Circulation 421.2 The Transitional Circulation 421.3 The Neonatal Circulation 421.4 Persistent Pulmonary Hypertension of the Neonate (Persistence of Fetal Circulatory Pathways) 421.5 The Influence of Fetal Environmental Factors on Adult Cardiovascular and Metabolic DiseaseSection 2. Evaluation of the Cardiovascular System 422 History and Physical Examination 423 Laboratory Evaluation 423.1 Radiologic Assessment 423.2 Electrocardiography 423.3 Hematologic Data 423.4 Echocardiography 423.5 Exercise Testing 423.6 MRI, MRA, CT, and Radionuclide Studies 423.7 Diagnostic and Interventional Cardiac CatheterizationSection 3. Congenital Heart Diseases 424 Epidemiology of Congenital Heart Disease 425 Evaluation of the Infant or Child with Congenital Heart Disease 426 Acyanotic Congenital Heart Disease: The Left-to-Right Shunt Lesions 426.1 Atrial Septal Defect 426.2 Ostium Secundum Defect 426.3 Sinus Venosus Atrial Septal Defect 426.4 Partial Anomalous Pulmonary Venous Return 426.5 Atrioventricular Septal Defects (Ostium Primum and Atrioventricular Canal or Endocardial Cushion Defects) 426.6 Ventricular Septal Defect 426.7 Supracristal Ventricular Septal Defect with Aortic Insufficiency 426.8 Patent Ductus Arteriosus 426.9 Aorticopulmonary Window Defect 426.1-0 Coronary-Arteriovenous Fistula (Coronary-Cameral Fistula) 426.11 Ruptured Sinus of Valsalva Aneurysm 427 Acyanotic Congenital Heart Disease: The Obstructive Lesions 427.1 Pulmonary Valve Stenosis with Intact Ventricular Septum 427.2 Infundibular Pulmonary Stenosis and Double-Chamber Right Ventricle 427.3 Pulmonary Stenosis in Combination with an Intracardiac Shunt 427.4 Peripheral Pulmonary Stenosis 427.5 Aortic Stenosis 427.6 Coarctation of the Aorta 427.7 Coarctation with Ventricular Septal Defect 427.8 Coarctation with Other Cardiac Anomalies and Interrupted Aortic Arch 427.9 Congenital Mitral Stenosis 427.1-0 Pulmonary Venous Hypertension 428 Acyanotic Congenital Heart Disease: Regurgitant Lesions 428.1 Pulmonary Valvular Insufficiency and Congenital Absence of the Pulmonary Valve 428.2 Congenital Mitral Insufficiency 428.3 Mitral Valve Prolapse 428.4 Tricuspid Regurgitation 429 Cyanotic Congenital Heart Disease: Evaluation of the Critically Ill Neonate with Cyanosis and Respiratory Distress 430 Cyanotic Congenital Heart Lesions: Lesions Associated with Decreased Pulmonary Blood Flow 430.1 Tetralogy of Fallot 430...

Bibliographic details
Hardbound, 3200 pages, publication date: JUL-2007
ISBN-13: 978-1-4160-2450-7
ISBN-10: 1-4160-2450-6
Imprint: SAUNDERS


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Last update: 25 Nov 2009
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