A Guide for the Synthetic Chemist To order this title, and for more information, click here Second Edition
Edited By Jie Jack Li, Pfizer Global Research and Development, Ann Arbor, Michigan, USA Gordon Gribble, Department of Chemistry, Dartmouth College, Hanover, NH, USA
Description Palladium chemistry, despite its immaturity, has rapidly become an indispensable tool for synthetic organic chemists. Heterocycles are
of paramount importance in the pharmaceutical industry and palladium chemistry is one of the most novel and efficient ways of making
heterocycles. Today, palladium-catalyzed coupling is the method of choice for the synthesis of a wide range of biaryls and heterobiaryls.
The number of applications of palladium chemistry to the syntheses of heterocycles has grown exponentially.
These developments
highlight the need for a monograph dedicated solely to the palladium chemistry in heterocycles and this book provides a comprehensive
explanation of the subject. The principal aim of the book is to highlight important palladium-mediated reactions of heterocycles with
emphasis on the unique characteristics of individual heterocycles.
1. Palladium chemistry of heterocycles has its ?idiosyncrasies?
stemming from their different structural properties from the corresponding carbocyclic aryl compounds. Even activated chloroheterocycles
are sufficiently reactive to undergo Pd-catalyzed reactions. As a consequence of &agr and &bgr activation of heteroaryl halides, Pd-catalyzed
chemistry may take place regioselectively at the activated positions, a phenomenon rarely seen in carbocyclic aryl halides. In addition,
another salient peculiarity in palladium chemistry of heterocycles is the so-called "heteroaryl Heck reaction". For instance, while intermolecular
palladium-catalyzed arylations of carbocyclic arenes are rare, palladium-catalyzed arylations of azoles and many other heterocycles readily
take place. Therefore, the principal aim of this book is to highlight important palladium-mediated reactions of heterocycles with emphasis
on the unique characteristics of individual heterocycles.
2. A myriad of heterocycles are biologically active and therefore of paramount
importance to medicinal and agricultural chemists. Many heterocycle-containing natural products (they are highlighted in boxes throughout
the text) have elicited great interest from both academic and industrial research groups. Recognizing the similarities between the palladium
chemistry of arenes and heteroarenes, a critical survey of the accomplishments in heterocyclic chemistry will keep readers abreast of
such a fast-growing field. We also hope this book will spur more interest and inspire ideas in such an extremely useful area.
This
book comprises a compilation of important preparations of heteroaryl halides, boranes and stannanes for each heterocycle. The large
body of data regarding palladium-mediated polymerization of heterocycles in material chemistry is not focused here; neither is coordination
chemistry involving palladium and heterocycles.
Many heterocycle-containing natural products (highlighted throughout the text) have
elicited great interest from both academic and industrial research groups. Recognizing the similarities between the palladium chemistry
of arenes and heteroarenes, a critical survey of the accomplishments in heterocyclic chemistry keeps readers abreast of this fast-growing
field. It is also hoped that this book will stimulate more interest and inspire new ideas in this exciting area.
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