By
George Koob, Molecular and Integrative Neurosciences Department , The Scripps Institute, La Jolla, California, USA
Michel Le Moal, Neurocentre Magendie Inserm U862, Universite´ Victor Segalen – Bordeaux 2, Bordeaux, France
Description
Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding
of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions
of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol,
nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction
of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular
and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging
in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological
and neuroadaptational level both from a historical and integrative perspective.
The book incorporates diverse finding with an emphasis
on integration and synthesis rather than discrepancies or differences in the literature.
Audience:
Graduate students and professionals in neuroscience, neurology, psychology.
