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| THE COMPREHENSIVE SOURCEBOOK OF BACTERIAL PROTEIN TOXINS
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Third Edition
Edited By
Joseph Alouf, Institute Pasteur de Lille, France
Michel Popoff, CNR Anaerobies et Botulisme Unite Bacteries anaerobies et Toxines Institut Pasteur, FRANCE
Description
Bacterial toxins play an important role in infectious diseases. Several are amongst the most potent biological agents known to man. Cholera,
pertussis, botulinum, clostridium and tetanus toxins are all produced by bacteria. In many cases, it is the toxin produced and not the
infectious agent itself that causes pathology. Botulinum toxin has now of course found clinical application as botox, and anthrax, and
other toxins, have potentially devastating effects if misused as an agent of biological terror. This book describes the major achievements
and discoveries relevant to bacterial protein toxins since the turn of the new century, illustrated by the discovery of more than fifty
novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more
than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand
how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates.
Audience
Researchers, Academics, Graduate Students and PhD's in general microbiology, clinical microbiology and infectious disease
Contents
Introduction
A 116-year story of bacterial protein toxins (1888-2004): From diphtheritic poison to molecular toxinology
Evolutionary aspects
of toxin-producing bacteria
Mobile genetic elements and pathogenicity islands encoding bacterial toxins
Regulation systems of toxin expression
Toxin secretion systems
Intracellular trafficking of bacterial protein toxins
Translocation of bacterial protein toxin into the cytosol
Bacterial toxins and virulence factors targeting the actin cytoskeleton and
intracellular junctions
Bacterial toxins and mitochondria
Toxins activating RHO GTPases and exploiting the cellular ubiquitin/proteasome
machineries
Toxin receptors
Molecular, functional and
evolutionary aspects of ADP-ribosylating toxins
Diphtheria toxin
Attack of the nervous system by clostridial toxins: Physical findings,
cellular and
molecular actions
Uptake and transport of clostridial neurotoxins
Bacillus anthracis toxins
Large clostridial cytotoxins
modifying small GTPasesBordetella protein toxins Vibrio Cholerae and Escherichia Coli thermolabile enterotoxin
The Shiga toxins: Properties and action on cellsHelicobacter pylori vacuolating toxinPasteurella multocida toxin
Cytolethal distending toxinsPseudomonas aeruginosa toxinsEscherichia coli heat- stable enterotoxin b
Paradigms and
classification of bacterial membrane -damaging toxins
Membrane damaging and cytotoxic phospholipasesBacteroides fragilis toxins
Structure and mode of action of RTX cytolysins
Genetics and phylogeny of RTX cytolysins
The family of two-component cytolysins
of Serratia and other
bacteria
Alpha-helix and Beta-barrel pore-forming toxins (leucocidins, alpha-, gamma- and
delta-cytolysins)
of Staphylococcus aureus
Aerolysin and related Aeromonas toxinsClostridium septicum pore-forming alpha-toxin
Clostridium perfringens epsilon toxin
Repertoire and general features of the family of cholesterol?dependent cytolysins
Comparative
three-dimensional structure of cholesterol-dependent cytolysins
Perfringolysin O and Intermedilysin: mechanisms of pore formation by
the
cholesterol-dependent cytolysinsPneumolysin: structure, function and role in diseaseListeriolysin
Enterococcus
faecalis cytolysin toxin
Streptolysin S: one of the most potent and elusive of all bacterial toxins
The group B streptococcal beta-haemolysin/cytolysin
Haemolysins of Vibrio cholerae and other Vibrio speciesClostridium perfringens enterotoxinBacillus
cereus enterotoxins, bi- and tri-component cytolysins and other
haemolysins
Uropathogenic Escherichia coli cytolysins
Escherichia coli, Vibrio and Yersinia species heat-stable enterotoxins
What are superantigens – Staphylococcal superantigens
and the diseases they cause
Streptococcal superantigenic toxins
Superantigenic toxin of Yersinia pseudotuberculosis
Comparative
three-dimensional structure of bacterial superantigenic toxins
Induction and modulation of inflammatory networks by bacterial protein
toxins
Clostridial toxins in the pathogenesis of gas gangrene
Staphylococcal exfoliative toxins
Medical applications of botulinum neurotoxins
Bacterial protein toxins as food poisons
Engineering of bacterial toxins for research and medicine
Engineered bacterial toxin vaccines
and adjuvants
Toxins as tools
Bacterial protein toxins as biological weapons
| Bibliographic details |
Hardbound, 1072 pages, publication date: DEC-2005
ISBN-13: 978-0-12-088445-2
ISBN-10: 0-12-088445-3
Imprint: ACADEMIC PRESS
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| Price and Ordering |
Price:
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USD 245
EUR 189.95
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Last update: 7 Sep 2009
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