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| ANNUAL REPORTS IN MEDICINAL CHEMISTRY, 40
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Edited By
Annette Doherty, Pfizer Global R&D, Sandwich Laboratories, United Kingdom
Included in series
Annual Reports in Medicinal Chemistry,
Description
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry
together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future
therapies. Sections I-IV are disease orientated and generally report on specific medicinal agents. Sections V and VI continue to emphasize
important topics in medicinal chemistry, biology, and drug design. Section VII looks at Trends and Perspectives in the pharmaceuticals
market.
Audience
For medicinal, pharmaceutical and organic chemists
Contents
I. CENTRAL NERVOUS SYSTEM DISEASES
1. Neuronal Nicotinic Acetylcholine Receptor Modulators: Recent Advances and
Therapeutic Potential (S.R. Breining et al.).
2. Recent Advances in Selective Serotonergic Agents (W.E. Childers, Jr.,
A.J. Robichaud).
3. BACE Inhibitors for the Treatment of Alzheimer's Disease (E.W. Baxter, A.B. Reitz).
4. Positron
Emission Tomography Agents for Central Nervous System Drug Development Applications (N. Scott Mason, C. Mathis).
II. CARDIOVASCULAR
AND METABOLIC DISEASES
5. Emerging Topics in Atherosclerosis HDL Raising Therapies (P.J. Sinclair).
6. Small Molecule
Anticoagulant/Antithrombotic Agents (R.M. Scarborough et al.).
7. CB1 Cannabinoid Receptor Antagonists (F. Barth).
8. Melanin-Concentrating Hormone as a Therapeutic Target (M.D. McBriar, T.J. Kowalski).
9. Glycogen Synthase Kinase-3 (GSK-3):
A Kinase with Exceptional Therapeutic Potential (J.W. Benbow et al.).
10. Inhibitors of Dipeptidyl Peptidase 4 as Therapeutic
Agents (S.L. Gwaltney II, J.A. Stafford).
11. Recent Advances in Therapeutic Approaches to Type 2 Diabetes (R. Sarabu, J. Tilley).
III. INFLAMMATORY, PULMONARY, AND GASTROINTESTINAL DISEASES
12. The TRPV1 Vanilloid Receptor: A Target for
Therapeutic Intervention (J. Guy Breitenbucher et al.).
13. Leukotriene Biosynthesis Inhibitors (R.W. Friesena, D. Riendeaub).
14. CXCR3 Antagonists (J.C. Medina et al.).
15. PDE7 inhibitors: chemistry and potential therapeutic utilities (F.
Vergne et al.).
IV. CANCER AND INFECTIOUS DISEASES
16. Inhibitors of Anti-apoptotic Proteins for Cancer
Therapy (S.W. Elmore et al.).
17. AKT Kinase and Hsp90 Inhibitors As Novel Anti-cancer Therapeutics (T. Machajewski et
al.).
18. Novel Strategies in HIV Prevention – Development of Topical Microbicides (B.E. Beer, J.E. Cummins, Jr.).
19.
New Developments in HIV Therapeutics (T.A. Lylea, M.D. Millerb).
20. Antibacterials for the Treatment of Gram Positive Infections
(J.B. McAlpinea, Morimasa Yagisawab).
21. Progress on New Therapeutics for Fungal Nail Infections (S.J. Baker et al.).
V. TOPICS IN BIOLOGY
22. Chemical Tools for Indications Discovery (A. Hopkins).
23. Structural Genomics
and Drug Discovery (A. Edwards et al.).
VI. TOPICS IN DRUG DESIGN AND DISCOVERY
24. Structural Genomics
and Drug Discovery (A. Edwards et al.).
25. G-Protein Coupled Receptor Inverse Agonists: Identification, Pharmacological
Relevance and Functional Assays (B.L. Chenard et al.).
26. The Utility of Metabonomics for Drug Safety Assessment (M. Delnomdedieu,
R.P. Schneider).
27. Computational Prediction of Blood-brain Barrier Permeation (D.E. Clark).
28. Pharmacogenetics
and Drug Development (H. Reiser).
VII. TRENDS AND PERSPECTIVES
29. Trends in Pharmaceutical Innovation (E.F.
Schmid, D.A. Smith).
30. To Market, To Market – 2004 (S. Hegde, M. Schmidt).
| Bibliographic details |
Paperback, 558 pages, publication date: DEC-2005
ISBN-13: 978-0-12-040540-4
ISBN-10: 0-12-040540-7
Imprint: ACADEMIC PRESS
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Price:
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Last update: 30 Nov 2009
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