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| FORENSIC DNA TYPING
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Biology, Technology, and Genetics of STR Markers
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Second Edition
By
John Butler, National Institute of Standards and Technology, Gaithersburg, Maryland, USA
Description
Since the enormously successful first edition of Forensic DNA Typing was published, the Human Genome Project has published a draft sequence
of the human genome and completed the ?finished? reference sequence. The advent of modern DNA technology has resulted in the increased
ability to perform human identity testing?desirable in a number of situations including the determination of perpetrators of violent
crime such as murder and rape, resolving unestablished paternity, and identifying remains of missing persons or victims of mass disasters.
The technology has been utilized in identifying remains from victims of the World Trade Center twin towers collapse following the terrorist
attacks of September 11, 2001, the President Clinton-Monica Lewinsky scandal, and the identification of the remains in the Tomb of the
Unknown Soldier. Indeed, our perceptions of history have been changed with DNA evidence that revealed Thomas Jefferson fathered a child
by one of his slaves. This book examines the science of current forensic DNA typing methods by focusing on the biology, technology, and
genetic interpretation of short tandem repeat (STR) markers, which encompass the most common forensic DNA analysis methods used today.
Ten new chapters have been added to accommodate the explosion of new information since the turn of the century.
Audience
Researchers and practitioners in forensic DNA analysis, forensic scientists, population geneticists, military and private and public forensic
laboratories (for identifying individuals through remains), and students of forensic science. Law enforcement, legal professionals, government/legal
policy makers.
Contents
Ch. 1: Overview & History of DNA Typing
Ch. 2: DNA Biology Review
Ch. 3: Sample Collection, DNA Extraction, and DNA Quantitation
Ch. 4:
The Polymerase Chain Reaction (DNA Amplification)
Ch. 5: Commonly Used Short Tandem Repeat Markers and Commercial Kits
Ch. 6: Biology
of STRs
Ch. 7: Forensic Issues
Ch. 8: Single Nucleotide Polymorphisms & Other Bi-allelic Markers
Ch. 9: Y-Chromosome DNA Testing
Ch.
10: Mitochondrial DNA Analysis
Ch. 11: Non-Human DNA and Microbial Forensics
Ch. 12: DNA Separation Methods
Ch. 13: DNA Detection Methods
Ch. 14: Instrumentation for STR Typing
Ch. 15: STR Genotyping Issues
Ch. 16: Laboratory Validation
Ch. 17: New Technologies, Automation,
and Expert Systems
Ch. 18: CODIS and DNA Databases
Ch. 19: Basic Genetic Principles, Statistics, & Probability
Ch. 20: STR Population
Database Analyses
Ch. 21: Profile Frequency Estimates, Likelihood Ratios & Source Attribution
Ch. 22: Approaches to Statistical Analysis
of Mixtures and Degraded DNA
Ch. 23: Kinship and Parentage Testing
Ch. 24: Mass Disaster DNA Victim Identification
App I: Reported STR
Alleles
App II: Population Data-STR Allele Frequencies
App. III: Suppliers of DNA Analysis Supplies
App. IV: DAB QA Standards
App. V:
DAB Recommendations on Statistics
App. VI: NRC II Recommendations
App. VII: Example DNA Cases
| Bibliographic details |
Hardbound, 688 pages, publication date: FEB-2005
ISBN-13: 978-0-12-147952-7
ISBN-10: 0-12-147952-8
Imprint: ACADEMIC PRESS
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Last update: 22 Sep 2009
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