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| MOLECULAR DIVERSITY AND COMBINATORIAL CHEMISTRY, 24
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 Principles and Applications
To order this title, and for more information, click here
By
Michael Pirrung, Levine Science Research Center,
Duke University, Durham, USA
Included in series
Tetrahedron Organic Chemistry Series,
Tetrahedron Organic Chemistry Series, 24
Please click here to view paperback version
Description
The field of combinatorial chemistry has seen tremendous growth over the past decade, with a prominence that suggests it will have a continuing
impact.
Volume 24 in the Tetrahedron Organic Chemistry Series represents new approaches to solving problems in chemical reactivity
and function. It emphasises principles and exemplifies these with examples drawn from recent literature and thus is an excellent guide
to the conceptual framework of the field.
The textbook includes exercises and worked problems which can provide more independent
learning experiences and can also be used by an instructor leading a class on this topic.
This volume has been written with the advanced
undergraduate and graduate student in mind.
Audience
Advanced undergraduate students or graduate students
Contents
Nature: The Original Combinatorial Chemist
Biopolymers constitute natural libraries
Selection and evolution
The expression
of genetic information
Combinatorial assembly of antibody genes
Molecular solutions to combinatorial problems
Synthetic
Peptide Libraries
Solid-phase peptide synthesis
Peptides on pins
Other iterative deconvolution strategies
Examples
of split/couple/mix peptide libraries
Positional scanning
Epilogue
Supports, Linkers, and Reagents for Peptide
Synthesis
Polystyrenes
PEG-grafted supports
Coupling strategies
Supports and Linkers for Small Molecule Synthesis
New resins
and linkers
Ring-forming cleavage
Loading
Encoded Combinatorial Chemistry
Directed Sorting
Unnatural
Oligomers for Library Synthesis
Peptoids
Azatides
Peptidyl phosphonates
Oligoureas
Analytical Methods for
Solid-phase Synthesis
Product identification
Gel-phase NMR
High-resolution magic angle spinning NMR
On-bead infrared
spectroscopy
Mass spectrometry
Non-spectroscopic methods
Supported Solution-phase Synthesis
Polyethylene glycols
Dendrimers
Fluorous synthesis
Solution-phase Parallel Synthesis
Scavenging resins
Ion-exchange resins
Supported reagents
Fluorous reagents
Solid-phase extraction
Gas-phase separation
Multi-component Reactions
Chemical Informatics, Diversity, and Library Design
Strategies
Representative flowchart for a library design
Lipinski's
Rules
Nucleic Acid Microarrays
Combinatorial Materials Chemistry
Combinatorial Catalyst Discovery
Peptides
on Phage
Applications of phage display
Nucleic Acid Selection
Complex Combinatorial and Solid-phase Synthesis
Epibatidine
Mappicine
Dysidiolide
The Big Picture
| Bibliographic details |
Hardbound, 188 pages, publication date: SEP-2004
ISBN-13: 978-0-08-044493-2
ISBN-10: 0-08-044493-8
Imprint: ELSEVIER
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| Price and Ordering |
Price:
USD 210
EUR 170
GBP 115
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Last update: 27 Sep 2008
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