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| THE NEUROENDOCRINE IMMUNE NETWORK IN AGEING, 4
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Edited By
R.H. Straub, University Medical Center, Department of Internal Medicine I, Laboratory of Neuroendocrinoimmunology, Regensburg, Germany
E. Mocchegiani, Immunology Center, Research Department INRCA, Ancona, Italy
Included in series
NeuroImmune Biology,
Description
The book describes the mechanisms involved in the maintenance of neuroendocrine-immune interactions in ageing. The lack of this maintenance
leads to the appearance of age-related diseases (cancer, infections, dementia) and subsequent disability. The capacity of some hormones
or nutritional factors in restoring and remodelling the neuroendocrine-immune response during ageing is reported presenting possible
new anti-ageing strategies in order to reach healthy ageing and longevity.
Contents
I. Introduction.
Evolutionary aspects for the neuroendocrine immune network and ageing (R.H. Straub).
II. Ageing of the immune system.
Immunosenescence (R. Solana, G. Pawelec). Zinc-binding proteins (metallothionein
and α-2 macroglobulin) as potential biological markers of immunosenescence (E. Mocchegiani et al.). Neutrophil ageing and
immunosenescence (S.K. Butcher et al.). Apoptosis and ageing (A. Larbi et al.). MHC-unrestricted cytotoxicity in ageing
(M. Provinciali, A. Donnini, R.E. Francesca). Major histocompatibility complex polymorphisms and ageing (G. Candore et al.).
III. Ageing of the endocrine system.
Neuroplascticity in the human hypothalamus during ageing (M.A. Hofman,
D.F. Swaab). The role of growth hormone signalling in the control of ageing (A. Bartke et al.). Ageing and the adrenal cortex
(V. Lamounier-Zepter, S.R. Bornstein). Hormonal changes in ageing men (E. Plas, S. Madersbacher, P. Berger). Ageing and the endocrine
circadian system (Y. Touitou, E. Haus). Melatonin rhythms, melatonin supplementation and sleep in old age (R.F. Riemersma et al.).
IV. Ageing of the nervous system.
Age-related changes of the human autonomic nervous system (M. Agelink,
R. Malessa, D. Ziegler). Age-related alterations in autonomic nervous innervation (D.L. Bellinger, K.S. Madden, D. Lorton). Ageing and
the neuroendocrine system of the gut (M. El-Salhy). Modulating effects of nutrition on brain ageing (C. Bertoni-Freddari et al.).
Ageing-related role of nitric oxide in the brain (S. Mariotto et al.).
V. Links between one global system
and another global system during the ageing process.
Introduction (R.H. Straub). Plasticity of neuroendocrine-thymus interactions
during ontogeny and ageing: Role of zinc (E. Mocchegiani et al.). Adverse lucocorticoid actions and their relevance to brain
ageing (K. Dinkel, R.M. Sapolsky). Neuroendocrine immune aspects of osteoporosis during the ageing process (M. Peterlik).
VI.
The ageing process and chronic inflammatory diseases.
Neuroendocrine immune mechanisms of accelerated ageing in patients
with chronic inflammatory diseases (R.H. Straub, J. Scholmerich, M. Cutolo). Thyroid autoimmunity and ageing (S. Mariotti, G. Pinna,
A. Pinchera). The clinical importance of proinflammatory cytokines in elderly populations (H. Bruunsgaard, K. Krabbe).
VII.
Conclusions.
Possible new anti-ageing strategies related to neuroendocrine immune interactions (E. Mocchegiani, R.H. Straub).
Concluding remarks and future directions (I. Berczi, A. Szentivanyi).
| Bibliographic details |
Hardbound, 456 pages, publication date: JUL-2004
ISBN-13: 978-0-444-51617-6
ISBN-10: 0-444-51617-4
Imprint: ELSEVIER
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| Price and Ordering |
Price:
GBP 150
USD 250
EUR 205
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Last update: 13 Jun 2009
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