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| THE MANY FACES OF RNA
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To order this title, and for more information, click here
Edited By
D. Eggleston, Smithkline Beecham Parmaceuticals, Harlow, Essex, U.K.
Catherine Prescott, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, U.S.A.
Neil Pearson, SmithKline Beecham Pharmaceuticals, Harlow, Esses, U.K.
Description
The Many Faces of RNA is the subject for the eighth SmithKline Beecham Pharmaceuticals Research Symposia. It highlights a rapidly
developing area of scientific investigation. The style and format are deliberately designed to promote in-depth presentations and discussions
and to facilitate the forging of collaborations between academic and industrial partners.
This symposium focuses on several of the many
fundamental, advancing strategies for exploring RNA and its functions. It emphasizes the interplay between biology, chemistry, genomics,
and molecular biology which is leading to exciting new insights and avenues of investigation. The book explores RNA as a therapeutic
target, RNA as a tool, RNA and its interactions, along with chemical, computational, and structural investigations.
Contents
Introduction.
Overview:
RNA as a Therapeutic Target for Bleomycin, S.M. Hecht.
RNA: Chemistry, Structure and Interactions:
Synthetic RNA Modification and Cross-linking Approaches towards the Structure of the Hairpin Ribozyme and the HIV-1 Tat Protein Interaction
with TAR RNA, M.J. Gait, D.J. Earnshaw, M.A. Farrow, and N.A. Naryshkin.
The Ribosome - The Universal Protein-synthesizing Machine, R. Brimacombe.
tRNA Recognition by Aminoacyl-tRNA Synthetases, S. Cusack, A. Yaremchuk, and M. Tukalo. RNA-Protein Recognition
During RNA Processing and Maturation, G. Varani.
RNA as a Target/RNA as a Tool:
Exploiting RNA: Potential Targets, Screens
and Drug Development, C.D. Prescott, L. Hegg, K. Nurse, R. Gontarek, H. Li, V. Emerick, T. Sterner, M. Gress, G. Thom, S. Guth, and
D. Rispoli.
Structural Basis for Aminoglycoside Antibiotic Action, J.D. Puglisi.
Protein-RNA Recognition in a Highly Conserved
Ribosomal Domain Targeted by Thiazole Antibiotics, D.E. Draper.
Rnase P and Its Substrate, L.A. Kirsebom.
Interfering with
Gene Function at the RNA Level with Oligoymes - the Development of New Tools and Therapeutics, B.S. Sproat, S.T. George, M. Ma, and
A.R. Goldberg.
Progress towards Therapeutic Application of SELEX-derived Aptamers, B. Polisky.
Catalysis of Organic Reactions
by RNA - Strategies for the Selection of Catalytic RNAs, A. Jaschke.
Conclusions and Opportunities, B.W. Metcalf.
Appendix:
Abstracts of Posters.
Index.
| Bibliographic details |
Hardbound, 228 pages, publication date: DEC-1997
ISBN-13: 978-0-12-233210-4
ISBN-10: 0-12-233210-5
Imprint: ACADEMIC PRESS
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| Price and Ordering |
Price:
USD 175
GBP 100
EUR 144
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Last update: 27 Sep 2008
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