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| NEUROBIOLOGY OF DIABETIC NEUROPATHY, 50
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Ronald Bradley, Louisiana State University Medical Center, School of Medicine, Baton Rouge, U.S.A.
David Tomlinson, University of Manchester, United Kingdom
R. Harris, University of Texas, Austin, U.S.A.
Peter Jenner, King's College, London, U.K.
Description
This volume of International Review of Neurobiology defines primary biochemical causation of diabetic complications,
identifies cellular glucose transducers, balancing roles of protein kinase C and MAP kinases, and sets in context the role of apoptosis
and the interactive roles of neurons and Schwann cells. It also defines the cell biology of autonomic neuropathy, considers the balanced
needs of science, clinical practice, and economics in clinical trial design, provides the definitive evaluation of aldose reductase inhibitors,
and explains the failure of nerve growth factor.
Audience
Neurologists, pediatric neurologists, epileptologists, developmental neuroscientists, medical geneticists, and developmental biologists.
Contents
Primary mechanisms
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How does glucose generate oxidative stress in Peripheral Nerve? Irina Obrosova.
Glycation
in Diabetic Neuropathy: Characteristics, Consequences, Causes and Therapeutic Options, Paul Thornalley.
Secondary changes
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Protein Kinase C Changes in Diabetes -- Is the concept relevant to neuropathy? Joseph Eichberg.
Are MAP kinases glucose transducers
for diabetic neuropathies? Tertia D. Purves and David R. Tomlinson.
Neurofilaments in Diabetic Neuropathy, Paul Fernyhough
and Robert E. Schmidt.
Apoptosis in Diabetic Neuropathy, Aviva Tolkovsky.
Nerve and Ganglion Blood Flow in Diabetes: An
Appraisal, Douglas W. Zochodne.
Manifestations
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Potential Mechanisms of Neuropathic Pain in Diabetes Nigel
A. Calcutt.
Changes in nerve conduction velocity - What Are Their Mechanisms and What Do They Mean?
Joe Arezzo.
Neuropathology
and Pathogenesis of Diabetic Autonomic Neuropathy, Robert E. Schmidt.
The Role of the Schwann Cell in Diabetic Neuropathy, Luke
Eckersley.
Potential Treatment
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The Polyol Pathway and Diabetic Peripheral Neuropathy, Peter J. Oates.
Nerve Growth Factor for the Treatment of Diabetic Neuropathy: What went wrong, What went right and what does the future hold? Stuart
C. Apfel.
ACE Inhibitors -- Are there Credible Mechanisms for Beneficial Effects in Diabetic Neuropathy? Rayaz Malik and David
Tomlinson.
Clinical trials for drugs against diabetic neuropathy -- can we combine scientific needs with clinical and economic practicalities?
Dan Ziegler and Dieter Luft.
| Bibliographic details |
Hardbound, 482 pages, publication date: AUG-2002
ISBN-13: 978-0-12-366850-9
ISBN-10: 0-12-366850-6
Imprint: ACADEMIC PRESS
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| Price and Ordering |
Price:
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EUR 131.95
USD 185
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095/945
Last update: 3 Oct 2009
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