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Joseph Locker, Albert Einstein College of Medicine, Yeshiva University, New York, U.S.A.
Description An important and comprehensive review of an expanding research area. The book will combine all classical knowledge in the field with recent
advances to provide a full and comprehensive coverage of the field.
Transcription factors are important in regulating gene expression,
and their analysis is of paramount interest to molecular biologists studying this area. This book looks at the basic machinery of the
cell involved in transcription in eukaryotes, the factors involved in transcription and progresses to look at the regulatory systems
which control this machinery both within the cell and also in the wider systems of the mammalian organism.
Audience
Cell and Developmental Biologists, Molecular Biologists, Geneticists
Contents Contributors.
Abbreviations.
Preface.
Basic Machinery of Transcription:
RNA Polymerase II Transcription Machinery:
Architecture
of the Core Promoter.
Rate-limiting Steps in Gene Expression.
Assembly and Regulation of the TATA-binding Protein and Associated Factors.
Recruitment of the RNA Polymerase II Holoenzyme.
Events Subsequent to Transcription Initiation.
Conclusions and Prospects.
Regulatory
Transcription Factors and cis-Regulatory Regions:
Introduction.
Regulatory Transcription Factors.
Organization of cis-Acting
Regulatory Regions and Combinatorial Control.
Conclusions.
Chromatin Structure and Regulation of Transcription:
Introduction.
Chromosome Architecture and Transcription.
Nucleosome Structure.
Chromatin Remodeling and Histone Modification in Transcription.
Transcriptional
Activators That Remodel Chromatin.
Transcriptional Repressors That Remodel chromatin.
Conclusion.
DNA Binding by Transcription
Factors:
Principles of Protein-DNA Recognition.
Architecture of DNA-binding Domains.
Conclusions.
Cell Regulatory Systems:
Regulation of Transcription During the Cell Cycle:
Introduction.
An Emerging Role for Mammalian and Yeast CDKs in Transcriptional
Regulation.
Cdk7 and Cdk8: Two Components of the Basal Transcription Machinery.
The pRB Family of Proteins.
The E2F Transcription Factor.
c-Myc Transcription Factor and its Partners.
Role of p53 as Transcription Factor and Growth Suppressor.
M Phase Repression of Transcription.
Conclusion.
Regulation of Transcription by Extracellular Signals:
Introduction.
Mechanisms of Signal Transmission to
the Nucleus.
Mechanisms of Signal Transmission to the Nucleus.
Mechanisms of specificity and Diversity Generation in Signaling Pathways.
Modification of Transcription Factor Activity.
Perspectives and Future Directions.
Systemic Regulation:
Transcriptinal Regulation
of Early Lymphocyte Development:
Introduction.
Regulation of Early B-cell Commitment and Differentiation.
Development Decisions
in T Cells: Regulation of CD4 Transcription.
Conclusions.
Transcriptional Integration of Hormone and Metabolic Signals
by Nuclear Receptors:
Introduction.
The Family and Its Ligands.
Targets and Genetics.
Modular Structure and Function.
Molecular
Mechanisms of Transcriptional Regulation.
Platforms for Multiple Signal Integration.
Deregulation in Disease and Novel Therapeutic Targets.
Conclusions.
Developmental Control by Hox Transcriptional Regulators and Their Cofactors:
Introduction.
Summary of Early
Embryonic Development of the Mammalian Body Plan.
Hox Protein Function: Regulation of Transcription.
Homeodomain Cofactors: TALE proteins.
Other HOX and PBC Cofactors: PREP, Hth and Meis.
Subcellular Localization.
'Coselective Binding' Model for Hox Functional Specificity
Versus the 'Widespread Binding/Activity Regulation' Model.
Transcriptional Regulation of Hox Gene Expression in the Developing
Embryo.
Conclusion.
Tissue-Specific Regulation by Transcription Factors:
Introduction.
Regulation of Hepatocyte Expression.
Developmental Relationship to Pancreas and Intestine.
Future Directions.
Neural Transcription Factors:
Introduction.
TFs in Neural Induction.
TFs in Brain Patterning.
TF Functions During Spinal Cord Development.
TFs in Neurologic Disorders and Neurodegeneration
Conclusions.
Abnormal Transcription Factors Produced by Chromosome Translocations in Human Cancer:
Introduction.
Chimeric
Transcription Factors in Human Leukemias.
Chimeric Transcription Factors in Human Sarcomas.
Summary.
Index.
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