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Brendan Wren, London School of Hygiene & Tropical Medicine, U.K. Nick Dorrell, London School of Hygiene and Tropical Medicine, UK
Description Functional Microbial Genomics, edited by two leading experts in the field, provides the researcher with an up-to-date
collection of articles on post-genome technologies central to studying the function of microorganisms.
Since the release of the first
complete genome sequence of a free-living organism in 1995, over 100 microbial genomes have been completely sequenced. The advent of
new technologies for post-genomic analyses has allowed the rapid exploitation of this genome sequence information, heralding a golden
era in microbial research. Functional Microbial Genomics provides in-depth accounts from scientists working with these
new technologies explaining both the techniques and the ways in which they have been applied to the study of gene function in different
microbial species.
Methods in Microbiology is the most prestigious series devoted to techniques and methodology in
the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested,
cutting edge protocols to directly benefit your research.
Audience
Micro and molecular biologists, geneticists, parasitologists, virologists, pharmacologists, biotechnologists
Contents
GENOME SEQUENCE ANALYSIS
Annotation of genomes
From sequence to consequence: in silico hypothesis generation and testing
The atlas visualisation of genome-wide information
CONSTRUCTION OF DNA MICROARRAYS
Microarray design for bacterial
genomes
Glass slides microarrays for bacterial genomes
COMPARAIVE NUCLEIC ACID ANALYSIS
Representational display analysis
of Cdna and genome comparisons
Application of DNA microarrays for comparative and evolutionary genomics
Gene expression during host-pathogen
interactions: approaches to bacterial mRNA extraction and labelling for microarray analysis
High throughput in vivo screens: signature-tagged
mutagenesis
Further strategies for signature-tagged mutagenesis and the application of oligonucleotide microarrays for the quantitation
of DNA-tagged strains
PROTEOME ANALYSIS
Advances in bacterial proteome analysis
Discovery of protein-protein interaction
using two-hybrid systems
SECTION V APPLICATIONS OF MICROBIAL GENOMICS
Cloning the metagenome: Culture-independent
access to the diversity and functions of the uncultivated microbial world
Reverse vaccinology: from genome to vaccine
Microbial genomics
for antibiotic target discovery
CASE STUDIES - BACTERIA
Helicobacter pylori functional genomics
Streptomyces coelicolor
A3(2): from genome sequence to function
Functional analysis of the Bacillus subtilis genome
SECTION VII CASE STUDIES - PARASITES
Plasmodium falciparum DNA microarrays and interpretation of data
Functional analysis of the Plasmodium falciparum genome using transfection
Chromosome fragmentation as an approach to whole genome analysis in trypanosomes
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