Edited by
Camille Wermuth, Prestwick Chemical, Illkirch, France
Description
Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists with little or no background in medicinal
chemistry. These chemists must acquire a good knowledge of medicinal chemistry during their first years in the pharmaceutical/drug
discovery industry. This book aims to be their practical handbook - a complete guide to the drug discovery process.
The book reviews
practical aspects of Medicinal Chemistry, emphasising the daily problems met by the medicinal chemist when dealing with lead discovery/identification
methodologies, with structure-activity relationship studies aimed to scale up potency and target selectivity, and when optimising pharmacokinetic
and pharmaceutical properties by means of ultimate chemical modifications.
This is the second edition of
The Practice of Medicinal
Chemistry, the first edition being published in February 1996. The new edition is thoroughly revised, with around 30% new material,
and refocussed to reflect the recent developments in genomics, proteomics, high throughput screening of compounds and drug solubilisation.
An effort has been made to remove the overlap that exists in the previous edition and four new chapters have been introduced.
Audience:
Academic and industrial organic chemists/pharmacologists beginning a career in drug research, established scientists teaching medicinal
chemistry, graduate and post-graduate medicinal chemists, biochemists, physical chemists, structural biologists, protein chemists, molecular
biologists, and researchers and scientists in the pharmaceutical industry.
