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| OXYGEN RADICALS IN BIOLOGICAL SYSTEMS, PART D, 234
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To order this title, and for more information, click here
John Abelson, California Institute of Technology, Division of Biology, Pasadena, U.S.A.
Helmut Sies, Institut Fur Physiologische Chemie, Germany
Melvin Simon, California Institute of Technology, Division of Biology, Pasadena, USA
Description
Since biological tissues are unstable in an oxygen atmosphere, a great deal of effort is expended by organisms to metabolically limit
or repair oxidative tissue damage. This volume of Methods in Enzymology and its companion Volume 233 present methods
developed to investigate the roles of oxygen radicals and antioxidants in disease. It includes techniques and assays of the activity
of biothiols in soluble systems, their interaction with lipids and proteins, and the various new thiol enzymes, such as thioltransferases,
being elucidated. Antioxidant reactions and gene regulation are also included.
Audience
Biochemists, pharmacologists, physiologists, and cell biologists.
Contents
Oxidative Damage to DNA and DNA Repair:
M. Dizdaroglu, Chemical Determination of Oxidative DNA Damage by Gas
Chromatography-Mass Spectrometry.M.K. Shigenaga, E.N. Aboujaoude, Q. Chen, and B.N. Ames, Assays of the Oxidative DNA Damage
Biomarker 8-Oxo-2-deoxyguanosine and 8-Oxoguanine in Nuclear DNA and Biological Fluids by High-Performance Liquid Chromatography with
Electrochemical Detection.K.K. Hamilton, K. Lee, and P.W. Doetsch, Detection and Characterization of Eukaryotic Enzymes That
Recognize Oxidative DNA Damage.W.A. Schulz, M.S.W. Obendorf, and H. Sies, Localization of Strand Breaks in Plasmid DNA Treated
with Reactive Oxygen Species.Y. Luo, E.S. Henle, R. Chatopadhyaya, R. Jin, and S. Linn, Detecting DNA Damage Caused by Iron
and Hydrogen Peroxide.P.K. Wong and R.A. Floyd, Photochemical Synthesis of 8-Hydroxyguanine Nucleosides.M.J. Burkitt,
Copper (DNA Adducts).J. Cadet. J.-L. Ravanat, G.W. Buchko, H.C. Yeo, and B.N. Ames, Singlet Oxygen DNA Damage: Chromatographic
and Mass Spectrometric Analysis of Damage Products.C. Baumstark-Khan, Alkaline Elution versus Fluorescence Analysis of DNA
Unwinding.L. Augeri, K.K. Hamilton, A.M. Martin, P. Yohannes, and P.W. Doetsch, Purification and Properties of Yeast Redoxyendonuclease.
C.F.M. Menck, Shuttle Vector between Prokaryotes and Eukaryotes for Assaying Singlet Oxygen-Induced DNA Damage and Mutagenicity.
B. Epe and J. Hegler, Oxidative DNA Damage: Endonuclease Fingerprinting.
Assay of Stress Genes/Proteins, Effects of
Reactive Oxygen Species and Antioxidants on Cell Regulatory Processes:
W. Drige, S. Mihm, M. Bockstette, and S. Roth,
Effect of Reactive Oxygen Intermediates and Antioxidants on Proliferation and Function of T Lymphocytes.R. Schreck and P.A. Baeuerle,
Assessing Oxygen Radicals as Mediators in Activation of Inducible Eukaryotic Transcription Factor NF-(B.S. Xanthoudakis and T. Curran,
Analysis of c-Fos and c-Jun Redox-Dependent DNA Binding Activity.D.R. Crawford, C.A. Edbauer-Nechaman, C.V. Lowry, S.L. Salmon,
Y.K. Kim, J.M.S. Davies, and K.J.A. Davies, Assessing Gene Expression during Oxidative Stress.G. Storz and S. Altuvia,
OxyR Regulon.R.M. Tyrrell and S. Basu-Modak, Transient Enhancement of Heme Oxygenase 1 mRNA Accumulation: A Marker of Oxidative
Stress to Eukaryotic Cells.J.S. Bertram and L.-X. Zhang, Assays for Regulation of Gap Junctional Communication and Connexin
Expression by Carotenoids.G.H.W. Wong and D.V. Goeddel, One-Day Northern Blotting for Detection of mRNA: NDGA Inhibits the
Induction of Mn-SOD mRNA by Agonists of Type 1 Receptor.C.E. Cross and B. Halliwell, Evaluation of Biomolecular Damage by Ozone.
B.K. Tarkington, T.R. Duvall, and J.A. Last, Ozone Exposure of Cultured Cells and Tissues.
Antioxidant Identification,
Characterization, and Assay: A. Total Antioxidant Status:
P.A. Motchnik, B. Frei, and B.N. Ames, Measurementof Antioxidants
in Human Blood Plasma.C. Rice-Evans and N.J. Miller, Total Antioxidant Status in Plasma and Body Fluids.
B. Natural
Source Antioxidants: Vitamin E:
W. Schaep and R. Rettenmaier, Analysis of Vitamin E Homologs in Plasma and Tissue:
High-Performance Liquid Chromatography.G. Riss, A.W. Kormann, E. Glinz, W. Walther, and U.B. Ranalder, Separation of the Eight
Stereoisomers of all-rac-(-Tocopherol from Tissues and Plasma: Chiral Phase High-Performance Liquid Chromatography and Capillary
Gas Chromatography.D.C. Liebler, Tocopherone and Epoxytocopherone Products of Vitamin E Oxidation.V.E. Kagan and L. Packer,
Light-Induced Generation of Vitamin E Radicals: Assessing Vitamin E Regeneration.M. Yamaoka and K. Komiyama, Antioxidative
Activity of Tocotrienol in Heterogeneous System: Indication of Restriction within Membrane by Fluorescence Measurement.G.T. Vatassery,
Determination of Tocopherols and Tocopherolquinone in Human Red Blood Cell and Platelet Samples.
Vitamin C:
G. Barja
and A. Hernanz, Vitamin C, Dehydroascorbate, and Uric Acid in Tissues and Serum: High-Performance Liquid Chromatography.M.
Inoue and K. Koyama, In Vivo Determination of Superoxide and Vitamin CRadicals Using Cytochrome c and Superoxide Dismutase
Derivatives.
Quinones:
V.E. Kagan, E.A. Serbinova, D.A. Stoyanovsky, S. Khwaja, and L. Packer, Assay of Ubiquinones
and Ubiquinols as Antioxidants.E.A. Serbinova and L. Packer, Antioxidant Properties of (-Tocopherol and (-Tocotrienol.
Glutathione:
M. Asensi, J. Sastre, F.V. Pallardo, J.M. Estrela, and J. Vita, Determination of Oxidized Glutathione in Blood: High Performance
Lipid Chromatography.
Carotenoids and Vitamin A:
M. Tsuchiya, V.E. Kagan, H.-J. Freisleben, M. Manabe, and L. Packer,
Antioxidant Activity of (-Tocopherol, (-Carotene, and Ubiquinol in Membranes: cis-Parinaric Acid-Incorporated Liposomes.A.R.
Sundquist, K. Briviba, and H. Sies, Singlet Oxygen Quenching by Carotenoids.W. Stahl and H. Sies, Separation of Geometrical
Isomers of (-Carotene and Lycopene.M.A. Livrea and L. Tesoriere, Lipoperoxyl Radical-Scavenging Activity of Vitamin A and Analogs
in Homogeneous Solution.
Flavonoids:
D.K. Das, Overview of Naturally Occurring Flavonoids: Structure, Chemistry,
and High Performance Lipid Chromatography Methods for Separation and Characterization.W. Bors, C. Michel, and M. Saran, Flavonoid
Antioxidants: Rate Constants for Reactions with Oxygen Radicals.A.E. Hagerman and L.G. Butler, Assay of Condensed Tannins or
Flavonoid Oligomers and Related Flavonoids in Plants.I. Morel, G. Lescoat, P. Cillard, and J. Cillard, Role of Flavonoids andIron
Chelation in Antioxidant Action.J.R.S. Hoult, M.A. Moroney, and M. Paya, Actions of Flavonoids and Coumarins on Lipoxygenase
and Cyclooxygenase.
(-Lipoic Acid:
Y.J. Suzuki, M. Tsuchiya, and L. Packer, Determination of Structure-Antioxidant
Activity Relationships of Dihydrolipoic Acid.
Extracts from Natural Products:
L. Marcocci, L. Packer, M.-T. Droy-Lefaix,
A. Sekaki, and M. Gardos-Albert, Antioxidant Action of Ginkgo biloba Extract EGb 761.
C. Synthetic Antioxidants:
Drugs:
H. Sies, Ebselen: A Glutathione Peroxidase Mimic.P. Moldeus and I.A Cotgreave, N-Acetylcysteine.M.E.
Anderson, E.J. Levy, and A. Meister, Preparation and Use of Glutathione Monoesters.E.J. Levy, M.E. Anderson, and A. Meister,
Preparation and Properties of Glutathione Diethyl Ester and Related Derivatives.S.J.T. Mao, M.T. Yates, and R.L. Jackson, Antioxidant
Activity and Serum Levels of Probucol and Probucol Metabolites.D.M. Lee, (-Phenyl N-tert-Butylnitrone as Antioxidant
for Low Density Lipoproteins.J.M. Carney and R.A. Floyd, Brain Antioxidant Activity of Spin Traps in Mongolian Gerbils.L.
Marcocci, Y.J. Suzuki, M. Tsuchiya, and L. Packer, Antioxidant Activity of Nitecapone and Its Analog OR-1246: Effect of Structural
Modification on Antioxidant Action.M. Miki, Penicillamine as Antioxidant.E.D. Hall and J.M. McCall, Antioxidant Action
of Lazaroids.A.M. Miles and M.B. Grisham, Antioxidant Properties of Aminosalicylates.L. Horakova, H. Sies, and S. Steenken,
Antioxidant Action of Stobadine.M.C. Krishna and A. Samuni, Nitroxides as Antioxidants.H. Wiseman, Tamoxifen and
Estrogens as Membrane Antioxidants: Comparison with Cholesterol.O.H. Morand, Reactivity of Plasmalogens to Singlet Oxygen and
Radicals.I.T. Mak and W.B. Weglicki, Antioxidant Activity of Calcium Channel Blocking Drugs.T.G. Gantchev, J.E. van Lier,
D.A. Stoyanovsky, J.C. Yalowich, and V.E. Kagan, Interactions of the Phenoxyl Radical of Antitumor Drug, Etoposide, with Reductants
in Solution and in Cell and Nuclear Homogenates: Electron Spin Resonance and High-Performance Liquid Chromatography.
Author Index.
Subject
Index.
| Bibliographic details |
Hardbound, 704 pages, publication date: AUG-1994
ISBN-13: 978-0-12-182135-7
ISBN-10: 0-12-182135-8
Imprint: ACADEMIC PRESS
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