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DRUG-DRUG INTERACTIONS: SCIENTIFIC AND REGULATORY PERSPECTIVES, 43
Drug-Drug Interactions: Scientific and Regulatory Perspectives, 43
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J. August, John Hopkins University; Department of Pharmacology, Baltimore, Maryland, U.S.A.
Albert Li, In Vitro Technologies, Inc., and University of Maryland Technology Center, Baltimore, Maryland, U.S.A.
Ferid Murad, University of Texas Medical School, Houston, U.S.A.
M. Anders, University of Rochester; Department of Pharmacology, New York, U.S.A.
Joseph Coyle, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, U.S.A.

Included in series
Advances in Pharmacology,

Description
Drug–Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug–drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug–drug interactions, the prediction of drug–drug interaction potential of new drugs, and the avoidance of clinically significant drug–drug interaction in patients.

Audience
Professionals in the pharmaceutical industry, health care industry, and governmental regulatory agencies. Students and researchers in the areas of pharmacology, toxicology, pharmacokinetics, and medicine.

Contents
J. Collins, Foreword.A.P. Li, Preface.A.P. Li, Overview: Scientific Basis of Pharmacokinetic Drug-Drug Interactions. F.P. Guengerich, Role of Cytochrome P450 Enzymes in Drug-Drug Interactions.J.M. Sauer, E.R. Stine, L. Gunawardhana, D.A. Hill, and I.G. Sipes, The Liver as a Target for Chemical-Chemical Interactions.A.D. Rodrigues and S.L. Wong, Applications of Human Liver Microsomes in Metabolism-Based Drug-Drug Interactions.A.P. Li, Applications of Human Hepatocytes as an Experimental System for the Evaluation of Pharmacokinetic Drug-Drug Interactions.J.L. Ferrero and K. Brendal, Liver Slices as a Model in Drug Metabolism and Drug-Drug Interactions.C.L. Crespi and B.W. Penman, The Use of cDNA Expressed Human Cytochrome P450 Enzymes to Study Potential Drug-Drug Interactions.G.L. Kedderis, Pharmacokinetics of Drug Interactions.T.N. Thompson, Experimental Models for Evaluating Enzyme Induction Potential of New Drug Candidates in Animals and Man and a Strategy for Their Use.J.D. Balian, Metabolic Drug-Drug Interactions: Perspective from U.S. FDA Medical and Clinical Pharmacology Reviewers.M. Jurima-Romet, Drug Interactions: Perspectives of the Canadian Directorate.

Bibliographic details
Hardbound, 304 pages, publication date: OCT-1997
ISBN-13: 978-0-12-032944-1
ISBN-10: 0-12-032944-1
Imprint: ACADEMIC PRESS

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Last update: 3 Oct 2009
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