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| ION CHANNELS AND DISEASE
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To order this title, and for more information, click here
By
Frances Ashcroft, University of Oxford, U.K.
Description
Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles
in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from
defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are
now referred to as the channelopathies.Ion Channels and Disease provides an informative and up-to-date account of our present
understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects
of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel,
the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce
the disease phenotype are considered.
This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates.
The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this
most exciting and medically important area of physiology.
Audience
Graduates and undergraduates in biological and biomedical sciences.
Contents
Preface.
Introduction.
From Gene to Protein.
How Channels Work.
Methods for Studying Ion Channels.
Voltage-Gated Na+ Channels.
Voltage-Gated K+ Channels.
Ca-Activated K+ Channels.
Inward Rectifier K+ Channels.
Voltage-Gated Ca2+
Channels.
Voltage-Gated Cl- Channels.
Cyclic Nucleotide-Gated Channels.
CFTR.
Epithelia Na+ Channels.
Ligand-Gated
Ca2+ Channels.
ACh Receptor Channels.
Glutamate Receptor Channels.
Glycine Receptors.
GABA Receptors.
Water Channels.
Gap
Junction Channels.
Antibodies to Ion Channels.
Ion Channels in Viruses.
Ion Channels as Lethal Agents.
A Miscellany of Ion Channels.
The Last Word.
References.
Subject Index.
Bibliographic & ordering Information
Hardbound, 481 pages, publication date: OCT-1999
ISBN-13: 978-0-12-065310-2
ISBN-10: 0-12-065310-9
Imprint: ACADEMIC PRESS
Price: Order form
USD 114
EUR 96.95
GBP 65.99
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095/945
Last update: 9 Jun 2008
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