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| ICRP PUBLICATION 90: BIOLOGICAL EFFECTS AFTER PRENATAL IRRADIATION (EMBRYO AND FETUS), 90
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By
. International Commission on Radiological Protection
Included in series
International Commission on Radiological Protection, 90
Description
In its 1990 recommendations, the ICRP considered the radiation risks after radiation exposures during prenatal development. This report
critically reviews new experimental animal data on biological effects and evaluations of human studies after prenatal radiation published
since then.
Thus, the report discusses radiation effects after exposure during preimplantation and developmental effects after irradiation
during organogenesis and fetogenesis. The etiology of long-term effects during brain developments is discussed, as well as evidence from
studies in man on the effects of in utero radiation exposure on neurological and mental processes. Assessments through animal studies
of carcinogenic risk from in utero radiation are treated, and the epidemiology of childhood cancer is discussed; from this information
the carcinogenic risk to man from in utero radiation is assessed. Open questions and needs for future research are elaborated.
The
report reiterates that the mammalian embryo and fetus are very radiosensitive during prenatal development. The nature and sensitivity
of induced biological effects depend upon dose and developmental stage at irradiation. The various effects, as studied in experimental
systems and in man, are discussed in detail. It is concluded that the findings in the report strengthen and supplement the recommendations
of the ICRP.
Contents
Preface
Introduction
1. Radiation effects after exposure during the pre-implantation period
2. Developmental Effects after
Irradiation during organogenesis and fetogenesis
3. Aetiology of long-term effects during brain development
4. Human evidence
on the effects of in-utero radiation exposure on neurological and mental processes
5. Carcinogenic Risk from In-Utero Irradiation:
Animal Studies
6. Epidemiology of Childhood Cancer
7. Human Carcinogenic Risk from In-Utero Irradiation
8. Summary and
Conclusions
9. Open Questions and needs of future research
Bibliographic & ordering Information
Paperback, 204 pages, publication date: OCT-2003
ISBN-13: 978-0-08-044265-5
ISBN-10: 0-08-044265-X
Imprint: ELSEVIER
063/663
Last update: 5 Aug 2008
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