Description It is widely recognized that analytical technologies and techniques are playing a pioneering role in a range of today's foremost challenging
scientific endeavours, including especially biological and biomedical research. Worthy of mention, for example, are the role that high
performance separation techniques played in mapping the human genome and the pioneering work done within mass spectrometry.
It is also
apparent that state-of-the-art pharmaceutical and biomedical research is the major driving force of the development of new analytical
techniques. Advancements in genomics research has provided the opportunity for a call for new drug targets for new technologies, which
has speeded up drug discovery and helped to counteract the trend towards inflation of R&D costs.
This book has been designed to be a
reference covering a wide range of protein and genomic material analysis techniques. Emerging developments are presented with applications
where relevant, and biological examples are included. It was developed to meet the ever growing need for a comprehensive and balanced
text on an analytical technique which has generated a tremendous amount of interest in recent years.
In addition, this book also serves
as a modern textbook for advanced undergraduate and graduate courses in various disciplines including chemistry, biology and pharmacy.
Authors of the individual chapters are recognized champions of their individual research disciplines and also represent contemporary
major research centres in this field.
Audience
Life sciences organizations; government labs; pharmaceutical and biotech industries & organizations; graduates and undergraduates studying
analytical chemistry, analytical biochemistry, pharmaceutical analysis and biotechnology.
Contents Preface; Enabling Bio-Analytical Technologies for Protein and Genomic Material Analysis and their Impact on Biology; DNA sequencing: from
capillaries to microchips; Phosphoprotein and phosphoproteome analysis by mass spectrometry; Quantitative peptide determination using
column-switching capillary chromatography interfaced with mass spectrometry; On-line continuous flow, multi-protein biochemical assays
for the characterization of bio-active compounds using electrospray quadrupole time-of-flight mass spectrometry; Capillary Isoelectric
Focusing Developments in Protein Analysis; Bio-Affinity Extraction for the Analysis of Cytokines and Proteomics Samples; Peptidomics-Based
Discovery of Endogenous Neuropeptides in the Brain; Beauty of Silicon Micromachined Microstructures interfaced to MALDI-TOF
Mass Spectrometry; Identification and characterization of peptides and proteins using Fourier transform ion cyclotron resonance mass
spectrometry; Biological Single Molecule Applications and Advanced Biosensing
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