By
David Wells, Sample Prep Solutions Company, Minnesota, USA
Description
High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies is an authoritative reference on the current state-of-the-art
in sample preparation techniques for bioanalysis. This book focuses on high throughput (rapid productivity) techniques and describes
exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. A thorough
review of the literature is included within each of these chapters describing high throughput sample preparation techniques: protein
removal by precipitation; equilibrium dialysis and ultrafiltration; liquid-liquid extraction; solid-phase extraction; and various on-line
techniques.
The text begins with an introductory overview of the role of bioanalysis in pharmaceutical drug development. Fundamental
understanding of the strategies for sample preparation is reinforced next, along with essential concepts in extraction chemistry. Several
chapters introduce and discuss microplates, accessory products and automation devices. Particular strategies for efficient use of automation
within a bioanalytical laboratory are also presented. The subject material then reviews protein precipitation, liquid-liquid extraction,
solid-phase extraction and various on-line sample preparation approaches. The book concludes with information on recent advances in sample
preparation, such as solid-phase extraction in a card format and higher density extraction plates.
Important objectives that can be
accomplished when the strategies presented in this book are followed include: improved efficiency in moving discovery compounds to preclinical
status with robust analytical methods; return on investment in automation for sample preparation; and improved knowledge and expertise
of laboratory staff.
Included in series
Progress in Pharmaceutical and Biomedical Analysis
Audience:
Researchers in pharmaceutical drug development, drug analysis and related clinical chemistry disciplines for therapeutic drug monitoring,
and forensic scientists who perform bioanalytical sample preparation.
