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| PROGRAMMED CELL DEATH, VOLUME I, 5
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Cellular and Molecular Mechanisms
To order this title, and for more information, click here
Edited By
S. Estus, Sanders-Brown Research Center on Aging, 101 Sanders-Brown Building, University of Kentucky, Lexington, KY 40536, USA
V. Rangnekar, Urology Department, 303 Combs Cancer Building, University of Kentucky, Lexington, KY 40536, USA
M.P. Mattson, Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore, MD, USA
Included in series
Advances in Cell Aging and Gerontology, 5
Description
Apoptosis, or programmed cell death, is an adaptive form of cell death that plays a critical role in turnover of mitotic cells and various
tissues in the adult, including epithelial cells, fibroblasts and various endocrine cells. Programmed cell death also plays a major
role in development in organizing the body plan and molding intricate cellular structures such as nerve cell circuits in the brain.
Rapidly progressing research into the molecular and biochemical underpinnings of the programmed cell death process are revealing novel
genetic programs and molecular interactions that coordinate a process that results in death and removal of cells without an immune response
and in the absence of the adverse effects on neighboring cells.
Programmed Cell Death, Volume I, critically details the molecular,
biochemical and cellular mechanisms of apoptosis. This volume covers programmed cell death in a variety of tissues and organ systems
highlighting the interesting families of proteins involved in promoting or preventing apoptosis. These include the caspase and calpain
families of proteases, Bcl-2 family members, and inhibitors of apoptosis proteins. Each chapter is written by an internationally recognized
expert in a particular aspect of programmed cell death.
This book will provide the reader with a comprehensive understanding of the
cascade of events leading from an apoptotic signal, such as trophic factor withdrawal or increased oxidative stress, to cell death.
Importantly, this volume also covers signaling mechanisms designed to prevent apoptosis. Such anti-apoptotic signaling cascades involve
neurotrophic factors and stress response pathways. Programmed Cell Death, Volume I, provides the molecular and cellular foundation
for Programmed Cell Death, Volume II in which the
roles of aberrant regulation of apoptosis in human diseases ranging from cancer to Alzheimer's disease are considered.
Contents
Preface.
Mechanisms Underlying the Hallmark Features of the
Execution-phase of Apoptosis
(J. Mills).
Death Domain Signaling
and Its Role in the Central Nervous System
(A.J. Bruce-Keller).
Diversity of Caspase Involvement in Neuronal Cell Death
(C.M.
Troy).
Mitochondrial Control of Apoptosis
(B. Mignotte, J.-L. Vayssiere).
Proliferative Mitochondrial Dysfunction and Apoptosis
(M. Mancini, S. Camilleri-Broet,
B.O. Anderson, D.M. Hockenbery).
The Bcl-2 Family of Proteins and their Actions within
The
Molecular Machinery of Cell Death
(Qing Guo, Sic L. Chan, I. Kruman).
The Role of Jun-Kinases in Apoptosis
(S.P. Tammariello,
G.E. Landreth, S. Estus).
Apoptosis by Par-4 Protein
(V.M. Rangnekar).
Cytoskeletal Involvement in Apoptosis
(R.K. Srivastava,
D.L. Longo).
Anti-apoptotic Role of the Transcription Factor NF-kB
(M.P. Mattson).
Inhibitor of Apoptosis Proteins (IAPS)
(Q.L. Deveraux, J.C. Reed).
Excitotoxins, Nitric Oxide and Programmed Neuronal Death
(M. Leist, P. Nicotera).
Contributor Addresses.
| Bibliographic details |
Hardbound, 368 pages, publication date: APR-2001
ISBN-13: 978-0-444-50493-7
ISBN-10: 0-444-50493-1
Imprint: ELSEVIER
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| Price and Ordering |
Price:
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EUR 91.95
USD 128
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Last update: 4 Sep 2009
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